Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

STEP 1 > QTS cards - Cardio Pharm > Flashcards

QTS cards - Cardio Pharm Flashcards

1
Q

indomethacin

A

closes PDA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

IVAbradine

A

Inhibit funny If

negative chronotropic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

dypiridamole

regadeNOson

A

vasodilators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Verapamil

Diltiazem

A

non-dihydropyridines
block initial Ca influx (voltage-dependent l-type ca channels) –> Dec contractility

AE - Negative chronotropic - Dec HR, Dec BP (severe in pts on B-blocker)
constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

nitroprusside AE

A

cyanide toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cyanide toxicity tx

A

sodium nitrate - methemoglobin
sodium thiosulfate - sulfur donor
hydroxocobalamin - bind cobalt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

isosorbide dinitrate

A

oral

high first pass metabolism - need higher dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Nitrate tolerance tx

A

Nitrate Free period

avoid tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Nitrate AE

A

lightheadness, hypotension, flushing, HA throbbing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

STATIN - MOA

HMG-COa reductase inhibitors

A

Dec hepatic cholesterol synthesis

by INC hepatocyte LDL receptor recycling to INC LDL clearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

STATIN - AE

HMG-COa reductase inhibitors

A

hepatotoxic (check LFTs)

myopathy, myalgias
INC CK - myonecrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fribrates

Gemfibrozil, -Fibrate

A

DEC TRIGLYCERIDES

up regulate LPL
activates PPAR-a –> DEC hepatic VLDL production

AE: myopathy, cholesterol gallstones
(INHIBIT cholesterol 7-a-hydroxylase; dec bile acid production –> cholesterol precipitate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Digoxin

A

MOA - Inhibit Na/K pump: DEC Na efflux –> Dec Ca efflux

slow AV conduction (Inc parasympathetic tone), but atrial flutter

HF tx
AE - YELLOW vision, nausea, vomit, flushing, diaphoresis (cholinergic)
hyperkalemia - arrhythmia =(

Inc toxicity - DEC renal clearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Disopyramide

A 
class IA 
Inhibit Na-channel (depress phase 0 depolarization)
Inhibit K-channel (Inc depolarization)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

LidocAiNe

A 
class IB
bind and block activated and inactivated Na channels

V Tach tx - 2nd line
affects ischemic ventricular tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Flecainide

A 
class IC
INC QRS - inhibit Na
no change in QT interval
17
Q

Class I - Na channel blocker

A

anti-arrhythmia
IC>IA>IB

IC - most use dependence

18
Q 
class III - K channel blocker
AIDS
A

anti-arrhythmia
INC AP duration
INC QT interval - lower incidence of torsade de points

19
Q

Amiodarone AE

A

class III
hepatotoxic
pulmonary fibrosis - check PFTs
thyroid toxic - check TSH

20
Q

Sotalol AE

A 
class III
torsade de pointes (syncope + polymorphic QRS that changes in amplitude, cycle)
21
Q

Adenosine

A

anti-arrhythmia (IV)
DOC x SVT - sudden onset of palpitation

Prolong Phase 4 (Inc K out –> hyper polarization, Dec Ca current)

AE - flushing, chest pain, bronchospasm/burning chest, SOB

use x chemical stress test

22
Q

Nitrate effect

A

DEC end systolic LV volume (bc decrease preload)
Dec O2 demand

INC HR (reflex tachy)

23
Q

Ca channel blockers

A

VErapamil > diltiazem > amlodipine

Bradycardia, slow AV conduction

AE - peripheral edema

24
Q

Ca channel blocker vascular smooth muscle

A

amlodipine = nifedipine > diltiazem > verapamil

vasodilator

25
Q

Non-selective B blockers

A

exacerbate and mask hypoglycemia severe sx

bc Ne/Epi block response

26
Q

Ezetimibe

A

prevent cholesterol absorption at small intestine brush border

27
Q

CHOLESTyramine

Bile acid resins

A

prevent bile acid reabsorption
Inc liver CHOLESTerol synthesis

Inc triglyceride

28
Q

B-blocker toxicity

A

Glucagon (Inc cAMP)

29
Q

nitrate

A

sublingual
Dilate veins&raquo_space; arteries
Dec preload = Dec LV volume

30
Q

Class III anti-arrhythmics

AIDS

A

Amiodarone
Ibutilide
Dofetilide
Sotalol

Prolong Phase 3 - depolarization
INC QT

31
Q

BENZtropine

A

muscarinic antagonist

TX: PARKinson Dz, acute dystonia

32
Q

Nimodipine

A

Ca channel blocker
dihydropyridines - act on vascular smooth muscle

TX x SAH (prevent cerebral vasospasm)

33
Q

Hydralazine

A

Vasodilator ARTERIES>veins

Dec vascular resistance –> Inc sympathetic –> INC fluid and sodium retention (RAAS)

34
Q

Niacin

A

INC HDL

AE - flushing face (INC prostaglandin)

35
Q

FenolDOPAm

A

TX - Hypertensive crisis
DOPAmine-1 receptor agonist
Dec BP, Inc natriuresis

36
Q

sotalol

A 
Torsade de pointes
class III

STEP 1 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions