Pulmonary & Critical Care Flashcards
Light’s criteria for pleural effusions
- Protein
- LDH
- Common causes

Tuberculous effusions
Exudative
Very high protein levels (>4 g/dL)
Lymphocytic leukocytosis
Low glucose (< 60 mg/dL)
Markedly elevated LDH levels (>500 U/L)
Low pH
Empyema
Presence of frank pus in pleural space
Prominent neutrophilic leukocytosis (>50,000 mm^3)
Measures to prevent aspiration pneumonia
Oral care
Diet modification for patients with dysphagia
Elevating the head of the bed to 30-45 degrees
Predisposing conditions for aspiration pneumonia

Pneumothorax (Spontaneous versus tension)
- Associated features
- Signs and symptoms
- Imaging
- Management


Tension pneumothorax
Blue arrows: Displaced mediastinal structures
Red arrows: Visceral pleural line, beyone which no pulmonary vasculature or lung parenchymal markings are apparent.


Collapsed lung

Cardiac tamponade

Flash pulmonary edema

Pleural effusions
Most common causes of malignant pleural effusions
Breast cancer
Lung cancer
Pulmonary contusion
Nonlobular airspace opacities
Develop <24 hours after trauma, resolve in 1 week

Seen in aortic rupture

Pneumomediastinum
Can result from traumatic esophageal rupture

Superior pulmonary sulcus tomor (Pancost tumor)
-Involvement of phrenic nerve causing hemidiaphragm paralysis and
elevation of right hemidaphragm
- Caused by primary lung malignancies (squamous cell carcinoma, adenocarcinoma)
- Smoking is the strongest risk factor

Clinical presentation of Pancoast tumor

Acute exacerbation of chronic obstructive pulmonary disease
- Cardinal symptoms
- Diagnostic testing
- Management

Interpretation of V/Q scan results based on pretest probability for PE
Range of outcomes for V/Q scan
LEAST LIKELY – normal, low probability, moderate probability, high probability – MOST LIKELY

Anticoagulation during pregnancy
Heparin (category C)
Low molecular weight heparin (category B)
Warfarin is category X (do not use)
Central versus peripheral cyanosis
- Signs
- Cause
Central cyanosis: Cyanosis in highly vascularized tissues such as lips and mucous membranes
Caused by low arterial oxygen saturation
Peripheral cyanosis: Cyanosis only in distal extremities
Caused by increased oxygen extraction secondary to sluggish blood flow

Bronchiectasis
Characteristic of cystic fibrosis
Differential diagnosis of hemoptysis in children
- Diagnosis
- Pathogenesis
- Clinical features


Diagphragmatic rupture
Elevation of hemidiaphragm on chest X ray
Nasograstric tube (red arrows) in pulmonary cavity is diagostic


Superior pulomonary sulcus tumor (Pancoast tumor)


Tuberculosis (reactivation)

Aspergilloma

Cryptogenic organizing penumonia
Dry cough and systemic symptos
Bilateral ground-glass infiltrates on CT

Lung abscess
Thick-walled cavitary lesion with air-fluid level
Cough, hemoptysis, fever, purulent sputum

Mesothelioma
Cough, chest pain, dyspnea in patients with significant asbestos exposure.
CT shows pleural thickening with effusion.
Oxygenation goal of mechanical ventilation
PaO2 50-80 mm Hg
O2 Saturation >=88%-95%
Pulmonary infarction (and effusion)


Bacterial pneumonia

Lung cancer
Treating pneumonia in cystic fibrosis patients
Vancomycin for staph aureus (younger patients <20 years)
Ciprofloxacin for Pseudomonas (older patients > 20 years)

Elevated or normal partial pressure of CO2 in a patient with acute asthma exacerbation
Suggests impending respiratory collapse
Indication for endotracheal intubation and mechanical ventilation
Causes of hypoxemia (Example, A-a gradient, Corrects with supplemental O2?)
- Reduced PiO2
- Hypoventilation
- V/Q mismatch
- Diffusion limitation
- Intrapulmonary shunt
- Intracardiac shunt (right to left)

Modified Wells criteria for pretest probability of pulmonary embolism

Diagnostic strategy in suspected pulmonary embolism

Nonallergic rhinitis versus allergic rhinitis
- Clinical features
- Treatment

Calculation of the A-a gradient
For patients breathing room air at sea level
150 - (PaCO2/0.8)
General equation
(FiO2 x [Patm - PH2O]) - (PaCO2/0.8)
Solitary pulomary nodule (SPN)
- Definition
- Management
- Definition
Rounded opacity
<3 cm
Completely surrounded by pulmonary parenchyma
No associated lymph node enlargement

Assessment of malignancy risk for solitary pulmonary nodule
- Nodule size (cm)
- Age (year)
- Smoking status
- Smoking cessation (year)
- Nodule margin characteristics

Aspirin-exacerbated respiratory disease
Occurs in patients with asthma and chronic rhunosinusitis
Sudden worsening of asthma and nasal congestion 30 minutes to 3 hours after ingestion of NSAIDS

Pulmonary aspergilloma
Invasive aspergillosis and chronic pulmonary aspergillosis
- Risk factors
- Findings
- Management

Actinomyces israelii
Anaerobic bacterium causing cervicofacial infections

Bacterial lung abscess
Indolent symptoms of fever, cough, dyspnea, weight loss
CT finding: infiltrate with a cavity (air-fluid levels)
Differential diagnosis based on carbon monoxide diffusing capacity of the lung
- Low
- Normal
- Increased

Common causes of hemoptysis
- Pulmonary
- Cardiac
- Infectious
- Hematologic
- Vascular
- Systemic diseases

Evaluation of hemoptysis
Patients should be placed with bleeding lung in the dependent position
Bronchoscopy is the initial procedure of choice: localize bleeding site, provide suctioning to improve visualization, and includes therapeutic interventions (balloon tamponade, electrocautery)

Clinical features of cystic fibrosis
- Respiratory
- GI
- Reproductive
- Musculoskeletal
Almost all males with CF are infertile from obstructive aspermia due to bilateral lack of vas deferens

Hyponatremia
- Serum osmolality
- ECV
- Urine findings
- Cause


Lung cancer

Radiation fibrosis
Chest X-ray shows volume loss with coarse opacities
Occurs in patients who have received lung field radiation.
Patients develop dyspnea, nonproductive cough, and chest pain 4-24 months after therapy
Postoperative pulmonary complications
- Risk factors
- Preoperative strategies (to reduce risk)
- Postoperative strategies

APGAR
(Sign, 0 points, 1 point, 2 points)
Scores < 7 may require evluation and resuscitation

Primary ciliary dyskinesia versus cystic fibrosis
- Respiratory tract features
- Extrapulmonary features
Detection of an elevated sweat chloride concentration is the gold standard for diagnosis

Characteristic findings of cor pulmonale
- Common etiologies
- Symptoms
- Examination
- Imaging
Cor pulmonale: Isolated right-sided heart failure (RHF) from pulomary hypertension, most commonly due to COPD

Obesity hypoventilation syndrome
- Diagnostic criteria
- Workup
- Treatment

Parapneumonic effusions (Uncomplicated versus Complicated)
- Etiology
- Pleural fluid gram stain & culture
- Treatment

Acute respiratory distress syndrome
- Risk factors
- Pathophysiology
- Diagnosis
- Management

First-line treatment for anaphylaxis
Intramuscular epinephrine

Hilar lymphadenopathy
Raises concern for malignancy, infection, or inflammation.

Right upper-lobe atelectasis
Linear density with associated shifting of mediastinum toward the collapsed lung
Epiglottitis
- Microbiology
- Clinical features
- X-ray
- Managment
- Prevention

Clinical features of asbestosis
- Clinical presentation
- Diagnostic evaluation
Cor pulmonale can develop eventually

Common etiologies of chronic cough
- Upper ariway disorder
- Lower airway and parenchymal disorders
- Other causes

Evaluation of subacute (3-8 weeks) of chronic (>8 weeks) cough

Sign of impending respiratory failure in acute asthma exacerbation
Normal or elevated PaCO2
Patients with an acute asthma exacerbation usually have respiratory alkalosis with a low PaCO2 due to hypoventilation.

Acute Respiratory Distress Syndrome
Risk factors

Respiratory distress syndrome
Prematurity
Male sex
Perinatal asphysxia
Maternal diabetes
Cesarean section without labor

Management of a patient with subcutaneous emphysema secondary to severe coughing paroxysms
Chest X rays to rule out pneumothorax
Air leaks from chest due to high intraalveolar pressure generated by cough
SIADH
- Etiologies
- Clinical features
- Laboratory findings
- Management

What improves survival in patients with COPD and hypoxemia?
Long-term supplemental oxygen therapy
Mediastinal masses
Anterior
Middle
Posterior
Anterior: Thymoma
Middle: Bronchogenic cyst
Posterior: Neurogenic tumor