Psychostimulants (3-28-14)

Question 1

What are the most commonly abused stimulants?

Answer 1

• cocaine
• amphetamine (ADHD) + methamphetamine (ecstasy)
• Ephedrine, phenyephrine, pseudoephedrine

Question 2

Cocaine MOA

Answer 2

inhibits NET and DAT = prevents NE and DA reuptake –> increases synaptic levels of NE + DA

Question 3

what does high dose of Cocaine cause?

Answer 3

blocks fast sodium channels in myocardium –> MI + Arrhythmias
increased myocardial O2 demand
procoagulant effect
vasoconstriction

Question 4

Amphetamine MOA

Answer 4

blocks VMAT –> can’t package NT into vesicles
reversal of DAT + NET +SERT direction
increased synaptic DA, NE, 5-HT

Question 5

Amphetamine S/E

Answer 5

psychosis = delusions, hallucinations, addiction

Question 6

methylene-dioxy-methamphetamine

Answer 6

Ecstacy (MDMA)

Question 7

Ecstasy MOA

Answer 7

blocks SERT –> increased serotonin in cleft

Question 8

Ecstasy Main Effect

Answer 8

fosters intimacy w/o imparing intellect

Question 9

Ecstasy Acute Toxicity

Answer 9

Serotonin Syndrome

Question 10

Ecstasy Withdrawl

Answer 10

depression, aggression

Question 11

Ecstasy Urban Legend

Answer 11

increases:

• insight
• self-knowledge

Question 12

caffeine at high doses causes

Answer 12

anxiety disorder

Question 13

Treatment for stimulant acute toxicity

Answer 13

CHARCOAL

benzodiazepines

Question 14

what is the MOA of NT degradation?

Answer 14

Monoamine Oxidase (MAO) on the OUTER MEMBRANE of the mitochondria