Limbic System Flashcards
Amygdala pathway: Basolateral nucleus
pathways to:
- cortex
- basal forebrain
- medial thalamus
Amygdala pathway: Corticomedial nucleus
pathways to:
-olfactory cortex
-hypothalamus
related to appetite state
Amygdala pathway: central nucleus
pathways to:
-hypothalamus
-brainstem
important in autonomic control
siezures involving the amygdala cause
fear and panic (bc its tied to the autonomic system)
what attaches emotional significance to various stimuli?
amygdala
Kluver-Bucy Sundrome: how do you get it? What behaviors does it cause?
remove both temporal lobes = destroy amygdala
- oral tendencies
- no emotion
- fearless
- hypersexual
the amygdala has complex interactions with what other systems?
limbic system hypothalamus ventral striatum septal area brainstem autonomics arousal system
what attaches emotional significance to olfaction?
amygdala
what is the major input and output relay between the association cortex and hippocampus?
Entorhinal Cortex
what are the neurons of the hippocampus?
granule cells –> make up the dentate nucleus
pyramidal cells: CA1, CA2, CA3, CA4
CA1 neurons very sensitive to ischemia
what 3 sets of neurons will be the first to die in an ischemic event?
big pyramidal neurons on the neocortex
pyramidal neurons CA1 in the hippocampus
purkinjie cells in cerebellum
mesial temporal sclerosis or hippocampal sclerosis will cause what? what does this cause molecularly?
seizures –> CA1 (neuronal loss and scarring/gliosis) part the hippocampus
If a lot of seizures, you can burn out the hippocampus
what is the Papez circuit?
hippocampal formation fornix mammillary bodies anterior n. thalamus cingulate gyrus cingulum parahippocampal gyrus
what is the alvear pathway?
entorhinal neurons –> CA1 + CA3
what is the perforant pathway?
entorhinal neurons granule cells on dentate gyrus --mossy fibers-- CA3 neurons --fornix + schaffer collaterals-- CA1 back to entorhinal neurons
