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NEURO > Glaucoma + Management (3/27/14) Gillepsie > Flashcards

Glaucoma + Management (3/27/14) Gillepsie Flashcards

1
Q

glaucoma risk factors

A

-high IOP
-positive FH
-Hispanic/AA
-Myopia = near sighted
-hypertension
-uveitis
-opthalmic trauma
STEROIDS!!!!

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2
Q

what do you give first if patient has closed-angle glaucoma?

A

IV Acetazolamide

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3
Q

What drugs decrease humor production?

A
  • B receptor antagonists (-lol)

- Carbonic Anhydrase Inhibitors (-zolamide)

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4
Q

What drugs increase humor outflow?

A
  • miotic agents (pilocarpine, physiostigmine)
  • PGF2a = prost’s
  • epinephrine-related agents (-ephrine/efrin)
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5
Q

Pilocarpine

A

cholinergic agonist
miotic agent
increases humoral outflow

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6
Q

Physiostigmine

A

ACh-E inhibitor
miotic agent
increases humoral outflow

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7
Q

toxicity of miotic agents

A

ciliary muscle spasm

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8
Q

CI of miotic agents

A
  • young patients intolerant of visual blurring

- patients w/ increased risk of retinal detachment

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9
Q

CI of B-receptor antagonists

A

ASTHMA
COPD w/ bronchospasm
arrythmias: bradycardia, heart block

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10
Q

latanoprost

A

PGF-2a prodrug
increases humoral absorption
FRONT LINE THERAPy

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11
Q

toxicity of epinephrine-related agents

A

systemic absorption –> systemic effects

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12
Q

dipivefrin

A

epi pro-drug

epinephrine-related agent

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13
Q

epinephrine

A

epinephrine-related agent

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14
Q

acetazolamide

A

carbonic anhydrase inhibitor

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15
Q

methazolamide

A

carbonic anhydrase inhibitor

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16
Q

toxicity/CI of CA inhibitors

A
  • malaise/fatigue
  • depression
  • parasthesias
  • KIDNEY STONES
17
Q

aproclondine (iopidine)

A

a2 selective agent

epinephrine-related agent

18
Q

reducing IOP by 30% does what?

A

decreases disease progression from 35-15% even in patients w/ normal IOP

19
Q

what the the order of treatment?

A

1 ) “prost” (alternative = b-blocker)
2/3 ) CA inhibitors, epinephrine-related agonists, and miotic agents
combo ) add topical agents
systemic ) add Carbonic Anhydrase inhibitors

NEURO (18 decks)

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