Drugs for Neurodegenerative Disorders Flashcards
1
Q
what’s the protein aggregate in Alzheimers
A
amyloid B
2
Q
what’s the protein aggregate in dementias
A
tau tangles
3
Q
what’s the protein aggregate in sporadic Parkinson’s
A
a-synuclein
4
Q
what’s the protein aggregate in Huntington’s
A
expanded polyglutamine repeats
5
Q
donepezil
A
Alzheimer inhibits AChE (CNS only)
6
Q
rivastigmine
A
Alzheimer
inhibits AChE
7
Q
galantamine
A
Alzheimer
inhibits AChE
8
Q
tarcrine
A
Alzheimer
inhibits AChE
9
Q
memantine
A
Alzheimer
NMDA receptor ANTAGONIST
10
Q
Tetrabenazine
A
Huntington’s
11
Q
haloperidol
A
Huntington’s
12
Q
clonazepam
A
Huntington’s
13
Q
riluzole
A
Amyotrophic Lateral Sclerosis (ALS)
14
Q
baclofen
A
anti-spastic drug
GABAb agonist
inhibits presynaptic and postsynaptic APs
sedation
15
Q
tizanidine
A
anti-spastic drug
a2 agonist (Gi)
inihbits presynaptic release of excitatory NT
sedation
16
Q
clonazepam / diazepam
A
GABAa agonist
opens Cl- channels
sedation
