Drugs for Neurodegenerative Disorders

Question 1

what’s the protein aggregate in Alzheimers

Answer 1

amyloid B

Question 2

what’s the protein aggregate in dementias

Answer 2

tau tangles

Question 3

what’s the protein aggregate in sporadic Parkinson’s

Answer 3

a-synuclein

Question 4

what’s the protein aggregate in Huntington’s

Answer 4

expanded polyglutamine repeats

Question 5

donepezil

Answer 5

Alzheimer
inhibits AChE (CNS only)

Question 6

rivastigmine

Answer 6

Alzheimer

inhibits AChE

Question 7

galantamine

Answer 7

Alzheimer

inhibits AChE

Question 8

tarcrine

Answer 8

Alzheimer

inhibits AChE

Question 9

memantine

Answer 9

Alzheimer

NMDA receptor ANTAGONIST

Question 10

Tetrabenazine

Answer 10

Huntington’s

Question 11

haloperidol

Answer 11

Huntington’s

Question 12

clonazepam

Answer 12

Huntington’s

Question 13

riluzole

Answer 13

Amyotrophic Lateral Sclerosis (ALS)

Question 14

baclofen

Answer 14

anti-spastic drug
GABAb agonist
inhibits presynaptic and postsynaptic APs
sedation

Question 15

tizanidine

Answer 15

anti-spastic drug
a2 agonist (Gi)
inihbits presynaptic release of excitatory NT
sedation

Question 16

clonazepam / diazepam

Answer 16

GABAa agonist
opens Cl- channels
sedation

Question 17

levodopa

Answer 17

Parkinson’s

Question 18

carbidopa

Answer 18

Parkinson’s

Question 19

entacapone

Answer 19

Parkinson’s

Question 20

bromocriptine

Answer 20

Parkinson’s

Question 21

ropinirole

Answer 21

Parkinson’s

Question 22

benztropine

Answer 22

Parkinson’s

Question 23

selegiline

Answer 23

Parkinson’s

Question 24

amantadine

Answer 24

Parkinson’s

Question 25

what secretases are involved in cleaving amyloid precursor protein (APP) normally and in AD?

Answer 25

``` normal = alpha + gamma secretase cleavage AD = beta + gamma secretase cleavage --> AB aggregates --> amyloid fibrils ```

Question 26

glycine

Answer 26

anti-spastic drug inhibitory NT crosses BBB

Question 27

pregabalin

Answer 27

anti-spastic drug | anti-epileptic

Question 28

gabapentin

Answer 28

anti-spastic drug | anti-epileptic

Question 29

dronabinol

Answer 29

anti-spastic drug CB1 receptor agonist dizziness, insomnia

Question 30

dantrolene

Answer 30

anti-spastic drug blocks RyR in SR --> prevents Ca release sedation

Question 31

clioquinol

Answer 31

novel treatment for AD

Question 32

ibuprofen

Answer 32

novel treatment for AD

Question 33

statins

Answer 33

novel treatment for AD

Question 34

estrogen

Answer 34

novel treatment for AD

Question 35

antioxidants

Answer 35

novel treatment for AD

Question 36

bapineuzumab

Answer 36

novel treatment for AD

Question 37

tramiprozate

Answer 37

novel treatment for AD

Question 38

flurizan

Answer 38

novel treatment for AD

Question 39

ampalex

Answer 39

novel treatment for AD | AMPA receptor

Question 40

coconut oil

Answer 40

novel treatment for AD

Question 41

implants of autologous skin cells --> NGF

Answer 41

novel treatment for AD