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NEURO > Drugs for Neurodegenerative Disorders > Flashcards

Drugs for Neurodegenerative Disorders Flashcards

1
Q

what’s the protein aggregate in Alzheimers

A

amyloid B

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2
Q

what’s the protein aggregate in dementias

A

tau tangles

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3
Q

what’s the protein aggregate in sporadic Parkinson’s

A

a-synuclein

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4
Q

what’s the protein aggregate in Huntington’s

A

expanded polyglutamine repeats

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5
Q

donepezil

A 
Alzheimer
inhibits AChE (CNS only)
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6
Q

rivastigmine

A

Alzheimer

inhibits AChE

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7
Q

galantamine

A

Alzheimer

inhibits AChE

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8
Q

tarcrine

A

Alzheimer

inhibits AChE

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9
Q

memantine

A

Alzheimer

NMDA receptor ANTAGONIST

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10
Q

Tetrabenazine

A

Huntington’s

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11
Q

haloperidol

A

Huntington’s

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12
Q

clonazepam

A

Huntington’s

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13
Q

riluzole

A

Amyotrophic Lateral Sclerosis (ALS)

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14
Q

baclofen

A

anti-spastic drug
GABAb agonist
inhibits presynaptic and postsynaptic APs
sedation

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15
Q

tizanidine

A

anti-spastic drug
a2 agonist (Gi)
inihbits presynaptic release of excitatory NT
sedation

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16
Q

clonazepam / diazepam

A

GABAa agonist
opens Cl- channels
sedation

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17
Q

levodopa

A

Parkinson’s

18
Q

carbidopa

A

Parkinson’s

19
Q

entacapone

A

Parkinson’s

20
Q

bromocriptine

A

Parkinson’s

21
Q

ropinirole

A

Parkinson’s

22
Q

benztropine

A

Parkinson’s

23
Q

selegiline

A

Parkinson’s

24
Q

amantadine

A

Parkinson’s

25
Q

what secretases are involved in cleaving amyloid precursor protein (APP) normally and in AD?

A 
normal = alpha + gamma secretase cleavage 
AD = beta + gamma secretase cleavage --> AB aggregates --> amyloid fibrils
26
Q

glycine

A

anti-spastic drug
inhibitory NT
crosses BBB

27
Q

pregabalin

A

anti-spastic drug

anti-epileptic

28
Q

gabapentin

A

anti-spastic drug

anti-epileptic

29
Q

dronabinol

A

anti-spastic drug
CB1 receptor agonist
dizziness, insomnia

30
Q

dantrolene

A

anti-spastic drug
blocks RyR in SR –> prevents Ca release
sedation

31
Q

clioquinol

A

novel treatment for AD

32
Q

ibuprofen

A

novel treatment for AD

33
Q

statins

A

novel treatment for AD

34
Q

estrogen

A

novel treatment for AD

35
Q

antioxidants

A

novel treatment for AD

36
Q

bapineuzumab

A

novel treatment for AD

37
Q

tramiprozate

A

novel treatment for AD

38
Q

flurizan

A

novel treatment for AD

39
Q

ampalex

A

novel treatment for AD

AMPA receptor

40
Q

coconut oil

A

novel treatment for AD

41
Q

implants of autologous skin cells –> NGF

A

novel treatment for AD

NEURO (18 decks)

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