Psychiatric Genetics

Question 1

Inheritance pattern of huntingtons disease?

Answer 1

Autosomal dominant

Question 2

Disease pattern of huntingtons?

Answer 2

Huntingtons gene codes for huntingtons triplet
Expansion of CAG triplet repeat
CAG codes for glutamine
More CAG repeats causes a longer chain of glutamines in the protein
Huntington protein becomes mis shapen
Gradual damage to brain cells
Neuronal loss

Question 3

Psychiatric symptoms of huntingtons

Answer 3

Depression 
Anxiety
Psychosis
Blunted affect 
Compulsions
Suicidality 
Aggression

Question 4

Cognitive symptoms of huntingtons

Answer 4

Decline in executive function
Short and long term memory deficits
Dementia

Question 5

Can huntingtons be genetically tested for?

Answer 5

Yes, v easy

Question 6

When does huntingtons normally present?

Answer 6

Usually asymptomatic until adulthood

Question 7

Treatment for huntingtons?

Answer 7

Irreversible and unstoppable so only symptomatic treatment

Question 8

Is bipolar disease genetic?

Answer 8

Yes

Question 9

Neuropathology of Alzheimer’s?

Answer 9

Formation of extracellular amyloid plaques

Inflammation and neurofibrillary tangles inside cells