Neurobiology Of Mood Disorders Flashcards
Does depression affect more men or women?
Women.
2:1
What is the risk of psychiatric admission 30 days following childbirth?
x7
How many women experience baby blues in the first 2 weeks?
75%
How many women develop MDD within 3-6 months?
10%
Changes to the HPA axis in major depression?
Increased secretion ACTH increased secretion cortisol Increased cortisol in urine and saliva Increased CRH in CSF Blunted ACTH to CRH Enlarged adrenal glands
Changes to the HPT axis in major depression?
Increased TRH in CSF
TSH Response to TRH is blunted
Increased TRH in CSF
TSH Response to TRH is blunted
What changes are seen in bipolar disorder on structural imaging?
Decreased grey matter volume (broadmann area 24, anterior singulate)
What changes are seen on functional imaging in bipolar disorder?
Increased metabolism in amygdala
What do postmortem studies show in bipolar disorder?
Decreased glial cell numbers with normal neuronal numbers - broadmann area 24