Protein Synthesis Inhibitors

Question 1

Aminoglycosides: GENTAMYCIN/TOBRAMYCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 1

1. Sight threatening corneal ulcers, bacterial infections
2. Inhibits protein synthesis at the 30s ribosomal subunit
3. SPK
   delayed corneal re-epithelialization
   Nephrotoxic and ototoxic

Question 2

TOBRADEX

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 2

1. Inflammatory conditions associated with a bacterial infection (marginal keratitis, corneal infiltrates)
2. Antibiotic/steroid combo
3. SPK
   Delayed corneal re-epithelialization
   Nephrotoxic and ototoxic
   Steroid SEs

CI: Epithelial defect

Question 3

Tetracyclines: TETRACYCLINE/DOXYCYCLINE

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 3

1. Doxycycline: acne rosacea, trachoma, adult inclusion conjunctivitis
   Minocycline: acne vulgaris
2. Inhibits protein synthesis at the 30s ribosomal subunit: Doxy alters the configuration of oil glands & decreases the release of FFA
3. Pseudotumor cerebri, bone growth retardation, teeth discoloration.

Minocycline: blue sclera, pigmented cysts on conj.

CI: PREGNANT WOMEN
Tetracycline: RENAL FAILURE

4. Doxycycline is safe in patients with renal failure, is eliminated in fecal matter instead of kidneys

Question 4

CHLORAMPHENICOL

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 4

1. Gram (+) and gram (-) bacteria
2. Inhibit protein synthesis at the 50S subunit
3. Aplastic anemia
   Optic neuritis

Question 5

Macrolides: ERYTHROMYCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 5

1.Prophylaxis of gonococcal ophthalmia neonatorum

2. Inhibit protein synthesis at the 50S subunit

Question 6

Macrolides: AZITHROMYCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 6

1. Oral: Chlamydial infections
   Topical: bacterial conjunctivitis, blepharitis
   Lyme disease
2. Inhibit protein synthesis at the 50S subunit
3. N/A
4. Azasite contains BAK, CL wearers should d/c use during tx

Convenient single 1 gram dose good for kids and older adults

Question 7

Macrolides: CLARITHYROMYCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 7

1. Respiratory infections
2. Inhibit protein synthesis at the 50S subunit

Question 8

LINCOMYCIN, CLINDAMYCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 8

1. MRSA, anaerobic infections
2. Inhibit protein synthesis at the 50S subunit REVERSIBLY