Antibiotics that Inferfere with Bacterial DNA

Question 1

Inhibitors of Folate Synthesis:
SULFONAMIDES

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 1

1. Ocular: Blepharitis, conjunctivitis
   Systemic: toxoplasmosis
2. Inhibits dihydropteroate synthase
3. Topical: burning
   Stinging
   Contact dermatitis
   Photosensitization
   Myopic shift

Systemic: SJS

Question 2

FOLATE ACID SYNTHESIS PATHWAY

Answer 2

PABA (synthase) –> dihydrofolate (reductase) –> tetrahydrofolate –> DNA

Question 3

Inhibitors of Folate Synthesis:
TRIMETHOPRIM

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 3

1. Gram (+) and gram (-), MRSA
2. Inhibits dihydrofolate reductase
3. Aplastic anemia
4. Not effective against pseudomonas

Question 4

Inhibitors of Folate Synthesis:
PYRIMETHAMINE

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 4

1. Ocular toxoplasmosis
2. Inhibits dihydrofolate reductase
3. N/A
4. Used w sulfonamide to treat toxoplasmosis

Question 5

Bactrim combination:

Answer 5

Sulfamethoxazole + trimethoprim

Question 6

Polytrim combination:

Answer 6

Trimethoprim + Polymyxin B