DNA Gyrase and Topoisomerase Blockers

Question 1

Fluoroquinolones: 2ND GEN
CIPROFLOXACIN, OFLOXACIN, NORFLOXACIN (CO2N)

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 1

1. CL related ulcers, corneal abrasions, bacterial conjunctivitis
   Gram (-) urinary and GI infections
2. Inhibits DNA Gyrase and Topoisomerase IV
3. Tendonitis (LONES bad for my BONES)
4. Safe to use in patients <1 years old

Question 2

Fluoroquinolones: 3RD GEN
LEVOFLOXACIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 2

1. Gram (+) and gram (-), CL related ulcers, corneal abrasions, bacterial conjunctivitis
2. Inhibits DNA Gyrase and Topoisomerase IV
3. Tendonitis (LONES bad for my BONES)
4. Only fluoro. NOT SAFE in patients <1 years old (LEVO that baby alone)

Question 3

Fluoroquinolones: 4TH GEN
GATIFLOXACIN, MOXIFLOXACIN, BESIFLOXACIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 3

1. Gram (+) and gram (-), CL related ulcers, corneal abrasions, bacterial conjunctivitis
   Moxi: pneumonia, sinusitis, skin infections
2. Inhibits DNA Gyrase and Topoisomerase IV
3. Tendonitis (LONES bad for my BONES)
4. Safe to use in patients <1 years old

Question 4

Other: MUPIROCIN

1. Indications
2. MOA
3. SEs and contraindications
4. Other

Answer 4

1. Impetigo
2. Inhibits protein and RNA synthesis by inhibiting isoleucyl-tRNA
3. N/A