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Pharmacology 2 > Protein Synthesis > Flashcards

Protein Synthesis Flashcards

1
Q

Oral availability of erythromycin?

A

Poor, but still used!

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1
Q

Treatment of local MRSA?

A

Mupirocin topically

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2
Q

Why would we use Minocycline?

A

Doxy shortage Better oral bioavailability

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2
Q

Spectrum of Fusidic Acid?

A

G+ MRSA in humans

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2
Q

What subunit does Avilamycin bind to?

A

30s

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3
Q

Spectrum of macrolides?

A

G+

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3
Q

Cross-resistance of Streptogramins?

A

Strep B and Macrolides/Lincosamides

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4
Q

Route of administration of Erythromycin in cattle?

A

IM

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5
Q

Route of administration of most tetracyclines?

A

PO

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6
Q

Macrolides and Lincosamides should not be used in what species?

A

Rabbits Gerbils, Guinea pigs Hamsters

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6
Q

Use of erythromycin?

A

Cattle R. equi in foals

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6
Q

Antibiotic used for gut sterilization?

A

Neomycin

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6
Q

Antibiotic used as a growth promoter outside the US?

A

Avilamycin

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7
Q

Treatment of septic arthritis in foals?

A

Amikacin used intra-articularly (extra-label)

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8
Q

Drugs that are taken up by phagocytes, thereby prolonging the effect?

A

Erytrhyromycin Tulathyromycin Azithromycin

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8
Q

Aminoglycosides are effective against what bacteria?

A

G- aerobes

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9
Q

Which Aminoglycosides can cause auditory injury?

A

Amikacin Neomycin

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9
Q

MOA of Mupirocin?

A

Bind to isoleucyl tRNA synthase

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11
Q

What routes of administration should be avoided with doxy?

A

IV-horses IM/SQ in all species

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12
Q

Species that Azithromycin is used in?

A

Small Animals (specifically for Mycoplasma, Chlamydia, Babesia)

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14
Q

Doxycycline is used in what species?

A

Small Animals

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14
Q

MOA of Amphenicols?

A

Inhibit peptidyl transferase

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15
Q

How do tetracylines work on G- bacteria?

A

Enter the pores

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16
Q

Antibiotic used to treat hepatic encephalopathy?

A

Neomycin But Lactulose is better

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16
Q

What antibiotic is used as a last resort drug in humans for MRSA, VRE, and TB?

A

Linezolid

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16
Q

MOA of Fusidic Acid?

A

Inhibit attachment of tRNA to the ribosome

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17
Q

Subunit that macrolides act on?

A

50s

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18
Q

What parameter should be closely monitored during the use of Aminoglycosides?

A

Renal function

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20
Q

MOA of tetracylines?

A

Inhibits aminoacyl transfer RNA

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22
Q

Spectrum of tetracylines?

A

Broad

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22
Q

Chlortetracyclines are used in what animals?

A

Food animals

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23
Q

MOA of macrolides?

A

inhibit translocation of ribosome

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24
Q

Species that Tilmicosin is used in?

A

Large Animals

25
Q

What subunit do amphenicols act on?

A

50s

26
Q

Lincomycin and Clindamycin should not be used in what species?

A

Horses Ruminants Lagomorphs

27
Q

Spectrum of Lincosamides?

A

G+

27
Q

MOA of Aminoglycosides?

A

Prevents attachment of tRNA Alters proofreading

28
Q

Which antibiotic has a post-antibiotic effect?

A

Aminoglycosides

29
Q

Aminoglycosides exhibit synergism with what other antibiotic?

A

Penicillins

31
Q

Oxytetracycline’s are used in what animals?

A

Food animals Horses (for Neoricketssia)

33
Q

Antibiotic that inhibits hepatic microsomal enzymes

A

Chloramphenicol

34
Q

Which antibiotic is more commonly used between Gentamicin and Amikacin?

A

Amikacin because of lower toxicity

34
Q

Spectrum of Streptogramins?

A

G+ including MRSA

36
Q

Side effects of amphnicoles

A

Bone marrow suppression Aplastic anemia

38
Q

Amphenicols antagonize what class of drugs?

A

Macrolides

40
Q

Uses of chloramphenicol?

A

Small Animals, especially with MRSA/MRSP

42
Q

Spectrum of amphenicols?

A

Broad

43
Q

Class of antibiotics that cause yellowing of teeth?

A

Tetracyclines

44
Q

Lincomycin has cross resistance with what other antibiotics?

A

Clindamycin (complete) Erythromycin (partial)

45
Q

Tylosin should not be used in what species?

A

Horses, small herbivores

46
Q

What are our Aminoglycoside drugs?

A

Gentamicin Tobramycin Amikacin Neomycin Apramycin/Spectinomycin

47
Q

Species that Tulathyromycin is used in?

A

Beef Non-lactating dairy Swine

48
Q

What are the bactericidal antibiotics?

A

Aminoglycosides

48
Q

Which Aminoglycosides can cause vestibular injury?

A

Gentamicin Tobramycin

49
Q

What subunit to Streptogramins bind to?

A

50s

50
Q

Spectrum of Linezolid?

A

All G+

52
Q

Class of drugs that “stop pearl stringing”

A

Amphenicols

54
Q

Distribution of Aminoglycosides?

A

Remain in ECF

55
Q

Spectrum of Avilamycin?

A

G+

56
Q

Antibiotic used to treat toxoplasma and anaerobic bacteria in small animals?

A

Clindamycin

57
Q

Which antibiotics are time dependent?

A

Tetracyclines Amphenicols Macrolides Lincosamides

58
Q

What subunit does Aminoglycosides bind to?

A

30s

59
Q

What subunit does tetracylines act on?

A

30s

60
Q

MOA of Linezolid?

A

Prevents iniation

60
Q

Route of administration of Fusidic Acid?

A

Topical Hepatotoxicity with parenteral use

62
Q

Tylosin is used in what species?

A

Cattle Swine SA (for diarrhea)

63
Q

Side effect of Erythromycin?

A

Vomiting

64
Q

Antibiotic that is fatal to humans with a needle stick?

A

Tilmicosin

65
Q

Antibiotic used to treat avian medicineoxa?

A

Apramycin/Spectinomycin

67
Q

Drug used to treat mastitis in dairy cattle via intramammary infusion?

A

Pirlimycin

68
Q

Which antibiotic is concentration dependent?

A

Aminoglycosides

70
Q

Route of admin for florfenicol?

A

IM SQ

72
Q

Route of administration of Gentamicin in small animal?

A

Parenteral

74
Q

Route of administration of chlortetracycline’s?

A

Water or feed additive

75
Q

Route of administration of Gentamicin in horses?

A

Intrauterine IV extra-label

76
Q

Macrolides should not be given orally to what species?

A

Ruminants Adult horses

77
Q

Side effects of Aminoglycosides?

A

Nephrotoxic Ototoxic Vestibular and auditory injury

78
Q

Florfenicol is used in what species?

A

Large Animals

79
Q

Tetracyclines are antagonistic to what class of antibiotics?

A

Penicilins

80
Q

Antibiotic used for resistant G- infection in small animals?

A

Amikacin

81
Q

Side effect of Tilmicosin

A

Cardiotoxicity- avoid IV

Pharmacology 2 (13 decks)

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