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Pharmacology 2 > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

Injectable proton pump inhibitor?

A

Pantoprazole
Lansoprazole

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1
Q

Laxatives that attract water into the GI lumen and are not absorbed?

A

Osmotic cathartics (Magnesium salts, sodium sulfate, sugar alcohols, polyethylene glycols, lactulose)

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2
Q

MOA of Misoprostol?

A

Inhibits cAMP decreasing protein kinase and hydrogen
Icreases mucous and sodium bicarb

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2
Q

Treatment of hepatic encephalopathy? MOA?

A

Lactulose
Ion trapping

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3
Q

Treatment of megaesophagus and megacolon?

A

Cisapride

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4
Q

Which H2 blocker inhibits hepatic microsomal enzymes?

A

Cimetidine

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4
Q

Prokinetic serotonin agonists?

A

Cisapride
Mosapride

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4
Q

Use of this class of GI drug can improve the eficacy of pancreatic replacement drug therapy?

A

H2 blockers

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5
Q

Laxatives that absorb water and swell stimulating GI reflex?

A

Simple bulk laxatives (Metamucil, wheat bran, prunes)

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6
Q

Which H2 blocker is much less potent than the others?

A

Cimetidine

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8
Q

Prokinetic H2 bockers?

A

Nizatidine
Ranitidine

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8
Q

Systemic antacid?

A

Sodium bicarb

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8
Q

GI drugs used in liver disease?

A

Lactulose
Ursodiol

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10
Q

Oral proton pump inhibitor?

A

Omeprazole

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11
Q

Anticholinergics are contraindicated in what species?

A

Horses

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12
Q

What makes Ranitidine and Nizatidine prokinetic?

A

Inhibit AChE to increase ACh

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13
Q

MOA of Metoclopramide?

A

5HT agonist so it stimulates gastric motility

14
Q

Oral antacids?

A

Magnesium and calcium salts

15
Q

What are the antiulcer drugs that are H2 blockers?

A

Cimetidine
Ranitidine
Nizatidine
Famotidine

15
Q

MOA of proton pump inhibitors?

A

Irreversibly inhibit H+/K+ ATPase

15
Q

Treatment of post-op ileus in horse?

A

Lidocaine

17
Q

Are proton pump inhibitors or H2 blockers more potent?

A

Proton pump inhibitors

18
Q

Proton pump inhibitor labeled for equine use?

A

Omeprazole

18
Q

Which pancreatic enzyme replacement therapy drug is most effective?

A

Viokase

20
Q

MOA of Cisapride and Mosapride?

A

5HT4 agonist

21
Q

Which opioid has a faster onset, longer duration, better efficacy, and doesnt cross the BBB?

A

Loperamide

23
Q

What antiulcer drugs are proton pump inhibitors?

A

Omeprazole
Pantoprazole
Lansoprazole

24
Q

Pancreatic enzyme replacement therapy drugs?

A

Viokase
Pancreazyme
Raw pancreas

25
Q

Laxatives that act as surfactant or stool softeners?

A

Emollient laxatives (Laxatone, Felilax)

27
Q

What antiulcer drug is a gastro protectant?

A

Sucralfate

27
Q

What are our prokinetic dopamine antagonists?

A

Metoclopramide
Domperidone

28
Q

Which H2 blockers do not effect GI motility?

A

Cimetidine
Famotidine

29
Q

Bile acid salt that increases bile flow (choleretic)?

A

Ursodiol

31
Q

MOA of Sucralfate?

A

Binds to ulcer site in an acidic environment

33
Q

Important side effect of Misoprostal?

A

Abortifacient

35
Q

Which drug is used to treat NSAID induced gastric ulcers?

A

Misoprostal

36
Q

Opioids used to treat diarrhea?

A

Diphenoxylate
Loperamide

37
Q

Antimicrobial that stimulates peristalsis?

A

Erythromycin

38
Q

What antiulcer drug is a prostaglandin analogue?

A

Misoprostol

40
Q

What receptor does Erythromycin bind to?

A

Motilin receptor in GI smooth muscle

41
Q

Laxatives that irritate the GI mucosa to stimulate motility and secretion?

A

Irritant cathartics (Bisacodyl, Phenophthalein)

42
Q

GI protectant that is anti-inflammatory and will turn stool dark?

A

Bismuth subsalicylate

Pharmacology 2 (13 decks)

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