Chemotherapy Flashcards
Chemotherapy drug that is administered as a prodrug?
Cyclophosphamide
Most common side effect of Doxorubicin?
Myelosuppression
GI
Dose-dependent cardiomyopathy in Dobermans, Rottweilers, giant breeds, and ABCB1 mutants
Nephropathy in cats
MOA of Doxorubicin?
Inhibits topoisomerase 2
Inhibits DNA helicase
Treatment of lymphoreticular neoplasms?
Vincristine
Cytosine Arabinoside
Prednisone
Administration of Vincristine with L-Asparaginase increases the risk of this side effect?
Myelosuppression
Why can Bisphosphonate and Alendronate treat cancer?
Osteoclast inhibitors
Doxorubicin is used in the treatment of what 3 cancers?
Lymphoma
Carcinoma
Osteosarcoma
Side effects of Lomustine and Carmustine?
Myelosuppression
Thrombocytopenia (reversible)
Chronic hepatotoxicity (irreversible)
Route of administration of Cyclophosphamide?
IV
PO
Treatment of lymphoreticular neoplasms, carcinomas, sarcomas, and TVT?
Vincristine and Vinblastine
Most common side effect of Cytosine Arabinoside?
Myelosuppression
Drug similar to Cisplatin used in cats?
Carboplatin
Route of administration of Methotrexate?
Parenteral
Oral
Major side effect of L-Asparaginase?
Anaphylaxis - give IM/SC to reduce the risk of this
Pancreatitis
Route of administration of Carmustine?
IV
Which vesicant do you treat extravasation using heat?
Vincristine and Vinblastine
MOA of Platinum compounds?
Bind to DNA residues causing cross-linking preventing replication
What is the most commonly used cytotoxic antibiotic?
Doxorubricin
Route of administration of Alendronate?
Oral
Route of administration of Cisplatin?
IV
Implant for dogs
Most common side effect of Methotrexate?
GI
Most common side effect of Cyclophosphamide?
Myelosuppression