Antibiotic Intro

Question 1

What type of bacteria usually acquire resistance through transformation?

Answer 1

G+

Question 1

Which staph is a normal commensal of dogs?

Answer 1

Staph pseudointermedius

Question 2

Causes of resistance?

Answer 2

Drug does not reach target site
Drug is inactivated
Target is changed
Chromosomal mutation
Transferred drug resistance

Question 2

When you give an antibiotic what are the possible bacterial responses?

Answer 2

Death
Slowing replication
Resistance
Superinfection

Question 3

Use of antibiotics at full doses to kill or inhibit pathogens in groups of healthy animals exposed to a pathogen?

Answer 3

Metaphylaxis

Question 4

Why are antibiotics that inhibit protein synthesis selective for bacteria?

Answer 4

Because bacterial ribosomes differ from mammalian ribosimes

Question 4

Use of antibiotics at low doses to make animals grow faster or use feed more efficiently?

Answer 4

Growth promotion

Question 5

Which bacteria uses a biofilm to acquire resistance?

Answer 5

Pseudomonas

Question 6

Causes of intrinsic resistance?

Answer 6

No target
Wrong cell wall
Wrong drug choice

Question 7

Antibiotics that kill more than the MBC?

Answer 7

Bacterialcidal

Question 8

Swapping of donor and recipient bacteria and plasmids?

Answer 8

Conjugtion

Question 8

Why is Staph aureus resistant to antibiotics?

Answer 8

Trandsuction

Question 10

Antibiotics that stop bacterial growth?

Answer 10

Bacteriostatic

Question 10

Antibiotics that kill more than the MIC?

Answer 10

Bacteriostatic

Question 13

Antibiotic mechanism that requires actively dividing bacteria?

Answer 13

Inhibition of cell wall synthesis
Inhibition of protein synthesis

Question 15

What are broad-spectrum antibiotics effective against?

Answer 15

G- and G+ bacteria

Question 17

Do antibiotics that disrupt cell membranes have a wide or narrow therapeutic index?

Answer 17

Narrow

Question 17

When you give an antibiotic what are the possible host responses?

Answer 17

No effect
Allergy
Residues
Toxicity
Drug interactions

Question 19

Mechanisms of antibacterial action?

Answer 19

Inhibition of cell wall synthesis
Inhibition of protein synthesis
Disruption of cell membranes
Inhibition of DNA synthesis and function

Question 20

Aggregation of microorganisms within a self-produced matrix?

Answer 20

Biofilm

Question 21

Bacteriophage takes DNA from one bacterium to another?

Answer 21

Transduction

Question 22

Picking up of naked DNA?

Answer 22

Trnsformation

Question 23

How can antibiotics be toxic?

Answer 23

Nephrotoxicity
Hepatotoxicity
Neuromuscular blockade
Ototoxicity
CNS excitement
GI upset
Bone marrow toxicity
Hypersensitivity
Cartilage damage in growing dogs

Question 24

Use of antibiotics at full doses to kill or inhibit pathogens causing disease in individual animals?

Answer 24

Treatment

Question 25

Antibiotics that need a competant immune system?

Answer 25

Bacteriostatic

Question 26

Which spectrum drug will exert less selection pressure on non-target organisms?

Answer 26

Narrow

Question 27

What bacteria commonly use conjugation to gain resistance?

Answer 27

G- and enterococci

Question 28

Antibiotics that kill bacteria?

Answer 28

Bactericidal

Question 29

Use of antibiotics at full or low doses to healthy animals to prevent disease?

Answer 29

Prophylaxis