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Pharmacology 2 > Histamine > Flashcards

Histamine Flashcards

1
Q

What antibody evokes histamine release from mast cells?

A

IgE

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2
Q

What are the first generation Ethanolamines?

A

Dimenhydrinate
Diphenhydramine (Benadryl®)

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2
Q

What are the second generation Piperadines?

A

Terfenadine
Astemizole
Loratadine (Claritin®)
Fexofenadine (Allegra®)

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3
Q

Which generation of H1 antagonists crosses the BBB?

A

1st generation

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3
Q

Which H2 blocker is not metabolized by cytochrome P450?

A

Nizatidine

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4
Q

Which H2 blockers are prokinetic?

A

Ranitidine
Nizatidine

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5
Q

What chemicals and drugs commonly induce release of histamine?

A

Morphine
Polymyxin
Castor oil

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5
Q

Whar are the first generation Piperazines?

A

Meclizine
Hydroxyzine
Cetirizine

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7
Q

Which histamine receptor is responsible for Inflammation, anaphylaxis, allergies, and drug reactions?

A

H1

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7
Q

Which H2 blocker has immunomodulatory effects?

A

Cimetidine

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8
Q

Which histamine pool is slow production?

A

Mast cell pool

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9
Q

Which H2 blocker inhibits cytochrome P450?

A

Cimetidine

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10
Q

Which generation of H1 antagonists are non sedating?

A

2nd generation

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12
Q

What drugs inhibit histamine release?

A

Epinephrine
Cromolyn sodium
Aminophylline
Glucocorticoids

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13
Q

What effect does H1 have on blood vessels?

A

Vasodilation causing hypotension and edema

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15
Q

What effect does H1 have on smooth muscles?

A

Constriction

15
Q

What is the first generation Alkylamine?

A

Chlorpheniramine

15
Q

Which generation of H1 antagonists are removed by p-glycoprotein?

A

2nd generation

17
Q

What is the first generation Methyl piperidine?

A

Cyproheptadine

18
Q

What are the H2 antagonists?

A

Cimetidine
Ranitidine
Famotidine
Nizatidine

19
Q

What is the effect of H2 activation?

A

Gastric acid secretion

21
Q

Which histamine pool allows for continuous release?

A

Non-mast cell pool

22
Q

Which H2 antagonists inhibits hepatic microsomal enzymes?

A

Cimetidine

23
Q

Which histamine receptor is responsible for gastric acid secretion?

A

H2

25
Q

What are the first generation Phenothiazines?

A

Promethazine
Trimeprazine-Prednisolone (Temaril-P®)

26
Q

What is the first generation Ethylenediamine?

A

Pyrilamine

Pharmacology 2 (13 decks)

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