Autacoids Flashcards

1
Q

What are our ACE inhibitors?

A

Captopril
Enalapril
Lisinopril
Benazepril

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1
Q

Phospholipase A2 inhibitor

A

Corticosteroids

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1
Q

Oclacitinib does not inhibit which JAK?

A

JAK2 (hematopoietic)

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3
Q

Inhibition of renin secretion?

A

Angiotensin 2
ADH
Hypertension
Increased reabsorption of sodium
Beta 1 adrenergic blockers

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4
Q

Autacoids that increase uveoscleral outflow by stimulating FP receptors in the eye?

A

Latanoprost
Travoprost
Bimatoprost

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4
Q

COX inhibitors?

A

NSAIDs

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5
Q

Clinical use of Fluoxetine?

A

Antidepressant

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5
Q

MOA of Zafirlukast?

A

Leukotriene receptor antagonist

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6
Q

Clinical use of Miropitant citrate (Cerenia®)?

A

Prevents and treats acute vomiting in dogs

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6
Q

MOA of Misoprostol?

A

Decreases acid secretion

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8
Q

Where do autacoids have effect?

A

Smooth muscle

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8
Q

Clinical use of Zafirlukast?

A

Prevents bronchoconstriction in asthmatic cats

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9
Q

What two classes of drugs are angiotensin 2 antagonists?

A

ACE inhibitors
Angiotensin 2 receptor antagonists

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9
Q

Reproductive drugs that cause luteolysis and stimulate motility?

A

Dinoprost trimethamine
Cloprostenol
Fenprostalene
Fluprostenol

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10
Q

MOA of Cisapride?

A

5-HT4 receptor agonist in enteric neurons

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10
Q

Stimulation of renin secretion?

A

Hypotension
Decreased renal blood flow
Low sodium or chloride in blood
Sympathetic stimulation (Beta 1 adrenergic)

11
Q

Clinical use of Mirtazapine?

A

Antidepressant
Antiemetic

12
Q

Angiotensin 2 stimulates the secretion of what?

A

Aldosterone

14
Q

MOA of Maropitant citrate (Cerenia®)?

A

Blocks NK1 receptors thereby preventing Substance P binding

16
Q

MOA of Ondansetron?

A

5HT3 antagonist

18
Q

MOA of Cyproheptadine?

A

H1 blocker
Serotonin antagonist

20
Q

Clinical use of Ondansetron?

A

Prevent nausea and vomiting

22
Q

MOA of Fluoxetine?

A

Selective serotonin reuptake inhibitor

22
Q

Clinical use of Latanoprost, Travoprost, and Bimatoprost?

A

Open-angle glaucoma
Ocular hypertension

23
Q

MOA of Zileuton?

A

5-Lipoxygenase inhibitor

25
Q

What is our angiotensin 2 receptor antagonist?

A

Losartan
Blockey type 1 receptors

26
Q

Effect of Metoclopramide centrally and peripherally?

A
Centrally = antiemetic
Peripherally = prokinetic
27
Q

MOA of Metoclopramide?

A

5HT3 antagonist
D1 and D2 antagonist

28
Q

Clinical use of Cyproheptadine?

A

Antihistamine
Appetite stimulant
Treatment of Serotonin syndrome

30
Q

Biological factors that act as local hormones, transmitters, and modulators

A

Autacoids

31
Q

What is the function of Renin?

A

Converts angiotensinogen to angiotensin 1

32
Q

JAK inhibitor?

A

Oclacitinib (Apoquel®)

33
Q

MOA of Mirtazapine?

A

Alpha 2 adrenergic antagonist
5HT2 and 5HT3 antagonist

34
Q

Clinical use of Misoprostol?

A

Antiulcer

35
Q

Clinical use of Zileuton?

A

Prevents asthmatic bronchoconstriction

36
Q

Serotonin is also known as?

A

5-HT