Protein structure Flashcards

1
Q

peptide bond

A

condensation reaction. covalend bond between the hydroxy and amino groups of. flat plane. only movement is 2 twists at either side of alpha carbon

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2
Q

protein structure heirarchy

A

primary
secondary
tertiary
quaternary

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3
Q

Primary protien structure

A

purely the chain of amino acids, no structure. only the order of amino acids

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4
Q

Secondary protein structure

A

beta sheet and alpha helic. local folding. folding at the alpha carbons, not the R groups yet. hydrogen bonds. (also random coil)

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5
Q

Tertiary protein structure

A

final shape of protein. ionic and hydrophobic affect (get hydophobic residues in centre of protein)

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6
Q

Quaternary

A

multiple proteins come together to form a larger system
homologous: same subunits
heterologous: different subunits

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7
Q

maintaining shape

A

hydrogen bonds
hydrophobic interactions: oil like side chains that don’t like water
ionic interactions
disulfide bonds:
post translational modifications
zinc finger motiff
chaperone proteins that help folding

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8
Q

zinc finger

A

small local fold with a zinc ion, stabilised by cysteine and histidine. extra force to hold some proteins together

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9
Q

Domains for proteins

A

a section of a protein that does something and can be present in multiple different proteins

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10
Q

what is a protein

A

a ribosome synthesised polypeptide chain of amino acids (and other elements/modifications), that under certain solvent conditions, performs functions according to its 3D structure

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