Prostate Cancer Flashcards

1
Q

who is this most common in?

A

black men
aged 70-74
FH
cadmium batteries

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2
Q

most common type

A

adenocarcinomas

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3
Q

metastatic sites

A

pelvic lymph nodes

bone

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4
Q

presentation

A

most asymptomatic
haematuria/ haematospermia
bone pain, anorexia, weight loss

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5
Q

diagnosis

A

DRE (peripheral zone cancers)
PSA
TRUS biopsy
bone scan, MRI, CT

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6
Q

causes of raised PSA

A
cancer
BPH
prostatitis
UTI
retention
catheterisation
DRE/PR
large prostate
bike rider
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7
Q

what MUST be done before PSA?

A

counselling

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8
Q

why do bad prognosis cancers not release PSA usually?

A

do not resemble cell of origin so do not release PSA

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9
Q

when is TRUS biopsy indicated?

A

abnormal DRE

elevated PSA

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10
Q

risks in TRUS biopsy

A

bleeding
sepsis
vaso-vagal fainting

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11
Q

grading of prostate cancer

A

Gleason score

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12
Q

staging of prostate cancer

A

TNM

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13
Q

TNM of organ-confined disease

A

T1-2, NO, MO

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14
Q

locally advanced TNM

A

T3-4, NO, MO

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15
Q

metastatic TNM

A

N+, M+

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16
Q

management of organ confined disease

A

surveillance
radical surgery (prostatectomy)
radiotherapy (EBRT, brachytherapy

17
Q

risks in prostatectomy

A

ED

incontinence

18
Q

complications of radiotherapy

A

haematuria
GI
ED
incontinence

19
Q

management of locally advanced

A

radiotherapy
hormonal therapy
watchful waiting

20
Q

management of metastatic disease

A

androgen deprivation therapy
chemotherapy
diethylstilbesterol/steroids

21
Q

androgen deprivation therapy

A

LHRH analogues
anti-androgens
bilateral orchidectomy

22
Q

what is the growth of prostate called controlled by?

A

testosterone
dihydrotestosterone

so if deprived they undergo apoptosis

23
Q

LHRH agonists complication

A

suppression of LH and FSH causing testosterone surge leading to spinal cord compression

24
Q

how to prevent testosterone surge?

A

anti-androgen cover

25
Q

examples of anti-androgens

A

steroidal (cyproterone acetate)

non-steroidal (nilutamide, flutamide and bicalutamide)