Prostaglandin Derivatives

Question 1

G-protein: Gq

effect: leukocyte chemotaxis
eicosanoid: ?

Answer 1

LTB4

Question 2

G-protein: Gq

effect: bronchoconstriction, slow-reacting substance of anaphylaxis
eicosanoid: ?

Answer 2

LTC4

Question 3

G-protein: Gq, Gi

effect: bronchoconstriction, slow-reacting substance of anaphylaxis
eicosanoid: ?

Answer 3

LTD4

Question 4

G-protein: Gs, Gq

effect: vascular smooth muscle relaxation, protective effects on gastric mucosa, maintains PDA
eicosanoid: ?

Answer 4

PGE1

Question 5

G-protein: Gs, Gq

effect: vascular smooth muscle relaxation, maintains PDA, increases uterine tone, vasodilation
eicosanoid: ?

Answer 5

PGE2

Question 6

G-protein: Gs
vascular smooth muscle relaxation (peripheral, pulmonary, coronary), vasodilation
eicosanoid: ?

Answer 6

PGI2

Question 7

G-protein: Gq

effect: increases uterine tone, decreases IOP, vasoconstriction, constriction of smooth muscles
eicosanoid: ?

Answer 7

PGF-2alpha

Question 8

G-protein: Gq

effect: platelet aggregation
eicosanoid: ?

Answer 8

TXA2

Question 9

Drug: alprostadil
analogue: PGE1
clinical use: ?

Answer 9

erectile dysfunction

Question 10

Drug: misoprostol, mifepristone, methotrexate
analogue: PGE1
clinical use: ?

Answer 10

NSAID-induced gastritis

Question 11

Drug: latanoprost
analogue: PGF-2alpha
clinical use: ?

Answer 11

chronic glaucoma

Question 12

Drug: dinoprostone
analogue: PGE2
clinical use: ?

Answer 12

abortifacient

Question 13

Drug: carboprost
analogue: PGF-2alpha
clinical use: ?

Answer 13

abortifacient

Question 14

Drug: aepoprostenol
analogue: PGI2
clinical use: ?

Answer 14

pulmonary hypertension