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Pharma Review > Anti-cholesterol Agents > Flashcards

Anti-cholesterol Agents Flashcards

1
Q

[anti-cholesterol agents]
MOA: HMG-CoA reductase inhibitor, lowers LDL
has CYP450 dependent metabolism
DOC for high cholesterol

A 
"-statin"
SIMVASTATIN
atorvastatin
rosuvastatin
fluvastatin
pravastatin
lovastatin
pitavastatin
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2
Q

[anti-cholesterol agents]

adverse SE: hepatotoxicity, rhabdomyolysis, myopathy

A 
"-statin"
SIMVASTATIN
atorvastatin
rosuvastatin
fluvastatin
pravastatin
lovastatin
pitavastatin
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3
Q

[anti-cholesterol agents]

statins that are prodrug

A

simvastatin
lovastatin
(all the rest are active form)

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4
Q

[anti-cholesterol agents]

decreases the absorption of statins

A

resins

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5
Q

[anti-cholesterol agents]
MOA: bile acid binding resin, lowers LDL
used for exclusive hypercholesterolemia

A 
bile acid resins
"chole-"
cholestyramine
colesevelam
colestipol
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6
Q

[anti-cholesterol agents]

adverse SE: constipation, steatorrhea

A 
bile acid resins
"chole-"
cholestyramine
colesevelam
colestipol

*avoid in patients with diverticulitis

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7
Q

[anti-cholesterol agents]
MOA: cholesterol absorption blocker, lowers LDL; selective inhibitor of NPC1L1
considered a prodrug

A

ezetimide

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8
Q

[anti-cholesterol agents]

adverse SE: hepatotoxicity especially with Statin use

A

ezetimide

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9
Q

[anti-cholesterol agents]
MOA: reduces all building blocks for hyperlipidemia, increases HDL, lowers LDL and TG
DOC for low HDL

A

niacin

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10
Q

[anti-cholesterol agents]

adverse SE: flushing, hyperglycemia, hyperuricemia

A

niacin

*avoid in patients with PUD

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11
Q

[anti-cholesterol agents]
MOA: PPAR-alpha activator (PPAR-gamma for DM), upregulates lipoprotein lipase, lowers triglycerides
DOC for high TGs

A 
fibrates
"-fibr-"
gemfibrozil
fenofibrate
bezafibrate
  • avoided in patient with hepatic or renal dysfunction
  • may increase LDL in patient with familial combined hyperlipoproteinemia
  • higher risk of gallstone formation if given with resins
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12
Q

[anti-cholesterol agents]

adverse SE: gallstones, additive myopathy

A 
fibrates
"-fibr-"
gemfibrozil
fenofibrate
bezafibrate
  • avoided in patient with hepatic or renal dysfunction
  • may increase LDL in patient with familial combined hyperlipoproteinemia
  • higher risk of gallstone formation if given with resins
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13
Q

why are statins used in the management of coronary artery disease?

A

for stabilization of atherosclerotic plaques

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14
Q

what are the drugs that cause cutaneous flushing?

A 
"cutie sa VANC"
vancomycin
adenosine
niacin
CCBs
*aspirin pretreatment reduces flushing
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15
Q

DOC for hypercholesterolemia

A

statins

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16
Q

DOC for hypertriglyeridemia

A

fibrates

17
Q

DOC for low HDL

A

niacin

18
Q

Fibrate + Resin

A

increased risk for cholelithiasis

19
Q

Statin + Resin

A

impaired statin absorption

20
Q

statin + fibrate

A

increased risk of myopathy and rhabdomyolysis

Pharma Review (15 decks)

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