Histaminergic/Serotonergic Drugs

Question 1

treatment of hypersensitivity (food allergy, rhinitis, hay fever, angioedema)

SE: sedation, anti-muscarinic effect

Answer 1

1st generation H1 blockers
“phen”

diphehydramine

Question 2

adjunct for motion sickness, vertigo

Answer 2

meclizine

Question 3

more anti motion sickness action, less sedative and autonomic effects

Answer 3

cyclizine

Question 4

less antimotion sickness, more sedative and autonomic effects

Answer 4

promethazine

Question 5

treatment of hypersensitivity, non-sedating

Answer 5

cetirizine, loratadine

Question 6

treatment of peptic ulcers, zollinger-ellison syndrome, GERD

SE: gynecomastia

Answer 6

cimetidine

Question 7

DOC for migraine and cluster headache

Answer 7

sumatriptan

Question 8

treatment for post op and post chemo vomiting

Answer 8

ondansetron (5HT3 receptor) at area postrema

Question 9

adjunct for migraine and cluster headache

Answer 9

ergotamine

Question 10

ergotamine toxicity antidote

Answer 10

nitroprusside

Question 11

treatment of postpartum bleeding

Answer 11

ergonovine

Question 12

SE: retroperitoneal fibrosis

Answer 12

methysergide

Question 13

MOA: competitive pharmacologic block of H2 receptors

Answer 13

"tidine"
cimetidine
ranitidine
famotidine
nizatidine