GI Drugs

Question 1

neutralizes stomach acids

SE: diarrhea-constipation (cancels each other)

Answer 1

aluminum hydroxide, MgOH

Question 2

greatly suppresses nocturnal acid secretion, H2 blocker

SE: gynecomastia

Answer 2

cimetide

Question 3

irreversible blockade of H+/K+ ATPase

DOC for peptic ulcer disease and Zollinger Ellison syndrome

Answer 3

omeprazole

Question 4

prokinetic agent, antiemetic,

DOC for diabetic gastroparesis

Answer 4

metoclopramide

Question 5

osmotic laxative, treatment of hepatic encephalopathy

Answer 5

lactulose

Question 6

stimulant laxative

SE: melanosis coli (umiitim ang colon)

Answer 6

senna

Question 7

opioid antispasmodic
DOC for noninfectious diarrhea
SE: paralytic ileus (in children)

Answer 7

loperamide

Question 8

mnemonic:
MAGnesium hydroxide causes diarrhea (MAGtatae ka!)
ALUMinum hydroxide causes constipation (Ayaw LUMabas)

Answer 8

mnemonic:
MAGnesium hydroxide causes diarrhea (MAGtatae ka!)
ALUMinum hydroxide causes constipation (Ayaw LUMabas)

Question 9

regimen for eradication of H. pylori infection (triple therapy)

Answer 9

“MBT”
metronidazole + bismuth subsalicylate + tetracycline
or
ranitidine bismuth citrate + tetracycline + clarithromycin/metronidazole
or
omeprazole + clarithromycin + metronidazole/amoxicillin

Question 10

regimen for eradication of H. pylori infection (quadruple therapy)

Answer 10

"TOMB"
tetracycline
omeprazole
metronidazole
bismuth subsalicylate

Question 11

[anti-neoplastic agents]

G2 phase

Answer 11

bleomycin

Question 12

[anti-neoplastic agents]

M phase

Answer 12

vinblastine
vincristine
paclitaxel

Question 13

[anti-neoplastic agents]

S phase

Answer 13

cytarabine
6-mercaptopurine
6-thioguanine
methotrexate
hydroxyurea
etoposide

Question 14

[anti-neoplastic agents]
G0 phase (cell cycle nonspecific agents)

Answer 14

alkylating agents
antitumor
antibiotics
nitrosureas (lomustine, carmustine)
cisplatin

Question 15

[alkylating agents]
treatment of lymphomas
SE: hemorrhagic cystitis,

rescue agent: Mesna

Answer 15

cyclophosphamide

Question 16

[alkylating agents]
for lymphoma (MOPP)
SE: marked vesicant actions (skin blistering)

Answer 16

mechlorethamine

Question 17

[alkylating agents]
treatment of colon cancer
SE: ototoxicity, nephrotoxicity

rescue agent: amifostine

Answer 17

cisplatin

carboplatin

Question 18

[alkylating agents]
for lymphoma
SE: disulfiram reaction, leukomogenesis

Answer 18

procarbazine

Question 19

[alkylating agents]
testicular and ovarian tumors,
most specific for the G2 phase
SE: pulmonary fibrosis, bone marrow-sparing

Answer 19

bleomycin

Question 20

[alkylating agents]
treatment of brain tumors
SE: CNS toxicity

Answer 20

carmusitne

Question 21

[anti-metabolites]
treatment of lymphomas and GTN
SE: myelosuppression, pulmonary fibrosis,

rescue agent: leucovorin (folinic acid)

Answer 21

methotrexate

Question 22

[anti-metabolites]
treatment of acute leukemias
SE: myelosuppression, hepatotoxicity, metabolism inhibited by allopurinol

Answer 22

6-mercaptopurine

Question 23

[anti-metabolites]
treatment of colorectal and skin cancer, causes thymine-less death of cells
SE: myelosuppression

Answer 23

5-fluorourscil

Question 24

[anti-metabolites]

treatment of CML in blast crisis, most specific for the S phase of the cell cycle

Answer 24

cytarabine

Question 25

[anti-metabolites] | inhibits ribonucleotide reductase, treatment of pancreatic cancer

Answer 25

gemcitabine

Question 26

[plant derivatives] vinca alkaloid, prevents microtubule assembly SE: peripheral neuropathy

Answer 26

vincristine | vinblastine (cause bone marrow suppression)

Question 27

[plant derivatives] | podophyllotoxin, inhibits DNA topoisomerase II, treatment of lung cancer, non- hodgkin's lymphoma and GTN

Answer 27

etoposide

Question 28

[plant derivatives] | camptothecin, inhibits DNA topoisomerase I, treatment of small cell lung cancer

Answer 28

topotecan

Question 29

[plant derivatives] | taxane, prevents microtubule disassembly, advanced breast and ovarian cancers

Answer 29

paclitaxel

Question 30

[anti-tumor antibiotics] intercalating agent SE: dilated cardiomyopathy rescue agent: dexrazoxane

Answer 30

doxorubicin

Question 31

[anti-tumor antibiotics] | treatment of melanoma, Wilms tumor and GTN

Answer 31

actinomycin D

Question 32

Drugs causing Pulmonary Fibrosis

Answer 32

``` "BBBAN Me" bleomycin busulfan bromocriptine amiodarone nitrofurantoin methotrexate ```

Question 33

[antineoplastics] tyrosine kinase inhibitor, treatment of CML SE: fluid retention, multiple drug interactions

Answer 33

imatinib

Question 34

[antineoplastics] | treatment of metastatic breast cancer, active against cells expressing HER-2/neu

Answer 34

trastuzumab

Question 35

[antineoplastics] | inhibits VEGF, treatment of metastatic cancers

Answer 35

bevacizumab

Question 36

[antineoplastics] | differentiation therapy, treatment of acute promyelocytic leukemia, only vitamin that can cure cancer

Answer 36

all trans retinoic acid | vitamin A

Question 37

Is the first available substance P antagonist used for the prevention of both sudden and delayed chemotherapy-induced nausea and vomiting

Answer 37

Aprepitant

Question 38

Used to stimulate appetite in patients with cancer-related cachexia

Answer 38

Megestrol

Question 39

Used in treatment of AIDS wasting, specifically to increase appetite

Answer 39

Dronabinol

Question 40

Effective for nausea and vomiting in chemotherapy

Answer 40

Granisetron