Anti-inflammatory Agents

Question 1

irreversibly inhibits cycloocygenase 1 and 2

Answer 1

aspirin

Question 2

reversible inhibitor of cyclooxygenase 1 and 2

Answer 2

ibuprofen

Question 3

irreversibly inhibits cyclooxygenase 2

Answer 3

celecoxib

Question 4

weak and reversible inhibition of cyclooxygenase, antipyretic of choice in pediatric population

Answer 4

paracetamol

Question 5

DMARD of choice for rheumatoid arthritis

Answer 5

methotrexate

Question 6

TNF-alpha blocker

Answer 6

infliximab

Question 7

forms 6-thiogunanine, and suppresses B cell and T cell function

Answer 7

azathioprine

Question 8

forms phophoramide mustard, which cross links DNA to prevent cell replication

Answer 8

cyclophosphamide

Question 9

its active metabolite is Sulfapyridine which inhibits the release of inflammatory cytokines

Answer 9

sulfasalazine

Question 10

inhibits microtubule assembly and LTB4 production leading to decreased macrophage migration and phagocytosis
SE: aplastic anemia

Answer 10

colchicine

Question 11

compete with uric acid for reabsorption in the proximal tubules

Answer 11

probenecid

Question 12

active metabolite (alloxanthine) irreversibly inhibits Xanthine Oxidase enzyme and lowers production of uric acid

Answer 12

allopurinol

Question 13

nonpurine, reversible inhibitor of xanthine oxidase, allopurinol intolerance

Answer 13

febuxostat