Prostaglandin And Other Eikosanoids Flashcards
Cyclooxygenase ____:
Found in many tissues and are active in many physiologic processes
1
Eikosanoids are produced from?
Arachidonic acid
Cyclooxygenase ____:
Found primarily in inflammatory cells
Major role in tissue injury
Synthesis of prostacyclin and prostaglandin
2
These constitute the Slow-reacting substances of anaphylaxis
Leukotriene C4, D4
Prostaglandin that is protective of gastric mucosa and keeps PDA patent
E1
Prostaglandin that increases uterine tone, also maintains PDA
E2
Pulmonary prostaglandin
I2
Prostaglandin that decreases IOP, increases uterine tone
F2alpha
Prostaglandin for Platelet Aggregation
TXA2
Causes increased HCO3 and mucus secretion in the stomach, also causes uterine contraction
Drug for PUD, prevention of NSAID induced gastric mucosal injury
SE: miscarriage, Moebius sequence
Drug, Class
Misoprostol, Prostaglandin E1 analog
Gemeprost
Causes vascular smooth muscle relaxation and vasodilation
Drug for maintenance of PDA, erectile dysfunction
SE: priapism, light headedness
Drug, Class
Alprostadil, Prostaglandin E1 analog
Low concentrations contract, higher concentrations relax uterine and cervical smooth muscle
Drug for induction of labor, cervical ripening, abortifacient
SE: cramps, fetal trauma
Drug, Class
Dinoprostone, Prostaglandin E2 analog
Sulprostone
Activates FP receptors
For control of postpartum hemorrhage, abortifacient
SE: Vomiting, diarrhea, transient bronchoconstriction
Drug, Class
Carboprost, Prostaglandin F2alpha analog
Bimatoprost, Travoprost, Unioprostone
Causes vasodilation, reduces platelet aggregation
Drug for pulmonary HPN, reduces platelet aggregation in dialysis machines
SE: hypotension, flushing, headache
EPOprostenol (as in Erythropoeitin)
Beraprost, Iloprost, Treprostinil
Increases outflow of aqueous humor
Reduces IOP
Drug for glaucoma
Alters iris color, causing permanent eye color change
Latanoprost, Prostaglandin F2alpha analog
Bimatoprost, Travoprost, Unoprostone
