Antibiotic Agents Flashcards
Bactericidal Antibiotics
Very Finely Proficient At Cell Murder Vancomycin Fluoroquinolones Penicillins Aminoglycosides Cephalosporins Metronidazole
Bacteriostatic Antibiotics
ECSTaTiC Erythromycin Clindamycin Sulfamethoxazole Trimetoprim Tetracycline Chloramphenicol
What Bacteriostatic antibiotics become bactericidal when combined?
TMP - SMX
Define: Lowest concentration capable of inhibiting growth of an organism
Minimum Inhibitory Concentration
MOA of Which Class of Drugs?
Binds to PBP
Inhibits Transpeptidation Reation
Activates Autolytic Enzymes
Beta Lactams
Mechanisms for Penicillin Resistance
Beta-lactamases
Structural changes in target PBPs
Changes in porin structures
Narrow spectrum Penicillin
Drug of Choice for Syphilis
SE: Hypersensitivity, cross-allergenicity with similar drugs, GI disturbances
Penicillin G
Renal Tubular Reabsorption of this drug is inhibited by Probenecid
Penicillin G
VERY NARROW spectrum Penicillin
DOC for Staphylococcal infections
SE: Hypersensitivity, cross allergenicity with similar drugs, GI disturbances, INTERSTITIAL NEPHRITIS, NEUTROPENIA
Resistant to beta-lactamase
Methicillin
(Naf/Oxa/Cloxacillin)
Use Naf for Staph.
Extended spectrum Penicillin Drug for Enterococci, Listeria, E. Coli, Proteus, H. Influenzae, MORAXELLA SE: Pseudomembranous Colitis, Rash Inactivated by beta-lactamase Enhanced with beta-lactamase inhibitors Synergistic effect with aminoglycosides
AMPicillin (AMPed up Penicillin)
AmOxicillin) (greater Oral bioavailability
Extended spectrum penicillins are effective for the following organisms
Hemophilus influenza E. Coli Listeria Proteus Salmonella spp. Enterococci
Amoxicillin HELPS kill Enterococci
Anti-pseudomonal Penicillin
Drug for Pseudomonas, Enterobacter, Klebsiella
SE: Hypersensitivity, Cross-allergenicity with similar drugs, GI disturbances
Inactivated by beta-lactamase
Enhanced with beta-lactamase inhibitors
Synergistic effect with aminoglycosides vs. Pseudomonas
Piperacillin
Ticarcillin, Carbenicillin
Anti-pseudomonal antibiotic with anti-platelet activity
Ticarcillin
Drugs for Pseudomonas
Takes Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin
First Generation Cephalosporin
Binds to PBP, inhibits transpeptidation
Drug for Surgical Prophylaxis, Bone Infection, E. Coli, Klebsiella, Proteus
SE: Hypersensitivity, partial cross-allergenicity with penicillins
Increases nephrotoxicity of aminoglycosides
CeFAZolin
FADer help me FAZ my PHarmacology boards
First Generation Cephalosporins
FADer help me FAZ my PHarmacology boards CeFADroxil CeFAZolin CePHalothin CePHradine CePHalexine
Second Generation Cephalosporin
Can cross BBB
Drug for Haemophilus, Enterobacter, and Neisseria
SE: Hypersensitivity, Disulfiram reaction with CefaMANdole and CefoTETan
Increases nephrogenicity of aminoglycosides
Cefamandole
FOXy FAMily in FUR, drinking TEa
CeFOXitin, CeFAMandole, CeFURoxime, CefoTEtan
FAC! LORA the PROfessional AZhOLE is on the FONe.
CeFAClor, LORAcarbef, CefPROzil, CefmetaZOLE, CeFONicid
Second Generation Cephalosporins
FOXy FAMily in FUR, drinking TEa
CeFOXitin, CeFAMandole, CeFURoxime, CefoTEtan
FAC! LORA the PROfessional AZhOLE is on the FONe.
CeFAClor, LORAcarbef, CefPROzil, CefmetaZOLE, CeFONicid
Third Generation Cephalosporin
Drugs for Pseudomonas and Bacteroides
SE: Hypersensitivity, Disulfiram reaction with Cefoperazone
Synergistic with AMINOGLYCOSIDES
FEnge Po ng PERA to FIX my TTTTTv CeFEtamet CefPOdoxin CefoPERAzone CeFIXime CefTriaxone CefTazidime CefoTaxime CefTizoxime CefTibuten
Third Generation Cephalosporin
FEnge Po ng PERA to FIX my TTTTTv CeFEtamet CefPOdoxin CefoPERAzone CeFIXime CefTriaxone CefTazidime CefoTaxime CefTizoxime CefTibuten
Wide coverage against gram positive and gram negative bacteria
SE: Hypersensitivity
Resistant to Beta-lactamase
CefePime
Porth (4th)
Anti-Pseudomonal Cephalosporins
CefTAZidime 3rd
CeFEPime 4th
CefoPERAzone 3rd
Carbapenem
Wide coverage against gram positive and gram negative bacteria
SE: Hypersensitivity, CNS Toxicity (Confusion, Enceph, Seizures)
Reserved for serious life threatening conditions
Imipenem-Cilastatin
This drug inhibits renal metabolism of Imipenem
Cilastatin
With Imipenem, Kill is LASTIN with CiLAStaTIN