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Pharmacology > Histamine, Serotonin, Ergot Alkaloids > Flashcards

Histamine, Serotonin, Ergot Alkaloids Flashcards

0
Q

Excess production of histamine is detectable in urine by measuring__________

A

Imidazole Acetic Acid

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1
Q

Most important amine autacoids

A

Histamine

Serotonin

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2
Q

Classic triad of histamine effect

A

Wheal
Flush
Flare

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3
Q

H1 receptors: 2nd messenger

A

IP3, DAG increase

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4
Q

H2 receptors: 2nd messenger

A

cAMP, increase

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5
Q

H3 and H4 receptors: 2nd messenger

A

cAMP, decrease

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6
Q

First generation H1 receptor antagonist
Peripheral and CNS H1 receptors plus alpha and M receptor block
Drug for hypersensitivity, light sedation and motion sickness
SE: drowsiness

A

Diphenhydramine

(Chlorpheniramine, Cyclizine, Meclizine (motion sickness), Promethazine

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7
Q

Second generation H1 receptor antagonist
Blocks peripheral H1 receptors, no autonomic or anti-motion sickness effects
Interaction with Azoles/Erythromycin and Terfenadine/Astemizole can lead to fatal arrhythmia

A

Cetirizine

Loratadine, Fexofenadine, Desloratadine, Terfenadine, Aztemizole

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8
Q 
Competitive pharmacologic block of H2
Reduction of gastric acid secretion
Drug for Peptic ulcer disease
SE: gynecomastia
CYP 450 Inhibitor
A

Cimetidine (only drug to cause gynecomastia)

Ranitidine, Famotidine, Nizatidine

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9
Q

Excess serotonin in the body can be detected by ___________ in the urine

A

5-hydroxyindole ascetic acid (5-HIAA)

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10
Q

What does HT in 5HT (Serotonin) stand for?

A

Hydroxytryptamine

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11
Q

5-HT3 receptor is found in ___________, an area in the brain associated with vomiting

A

Area postrema

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12
Q

5-HT1d/1b receptor agonist, causes vasoconstriction, modulates NT release
DOC for acute migraine (if still ongoing), cluster headache
SE: dizziness, vasospasm

A

Sumatriptan, Serotonergic Agent
(Almotriptan, Eletriptan, Frovatriptan, Naratriptan, Rizatriptan, Zolmitriptan)

LAHAT NG -TRIPTAN

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13
Q

5HT3 receptor antagonist
Pharmacologic antagonist for chemotherapy and post op vomiting
SE: QRS and QT prolongation (dolasetron), constipation (alosetron)

A

Ondansetron, Serotonergic Agent
(Granisetron, Dolasetron, Palonosetron, Alosetron)

LAHAT NG -SETRON

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14
Q

Produced from a fungus
Partial agonists at alpha adrenoreceptors and 5-HT receptors
VASOSELECTIVE, UTEROSELECTIVE, CNS SELECTIVE

A

Ergot Alkaloids

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15
Q

Produced from a fungus
Partial agonists at alpha adrenoreceptors and 5-HT receptors
VASOSELECTIVE, UTEROSELECTIVE, CNS SELECTIVE

A

Ergot Alkaloids

16
Q

5HT2 receptor VASOSELECTIVE antagonist
Drug for migraine, cluster headache
SE: retroperitoneal fibrosis

A

Ergotamine, Ergot Alkaloids

Dihydroergotamine, Methysergide

17
Q

Antidote for Ergotamine

A

Nitroprusside

18
Q

5HT2 receptor URETEROSELECTIVE antagonist
Drug for post-partum bleeding
SE: Abortion

A

Ergonovine, Ergot Alkaloid

Methylergonovine

Pharmacology (31 decks)

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