Preseason 5

Question 1

wilson disease laboratory findigns

Answer 1

low serum ceruloplasmin

high urinary copper

Question 2

liver nodule with a central scar

Answer 2

FOCAL NODULAR HYPERPLASIA

biopsy: central scar with morphologically abnoraml arteries accompanied by prominent ductular reaction

Question 3

(+) CK7, CK20, CK19

Answer 3

intrahepatic cholangiocarcinoma

Question 4

prominent Rokitansky-Aschoff sinuses

Answer 4

Chronic cholecystitis

“Outpouchings of the mucosal epithelium through the wall (Rokitansky-Aschoff sinuses) may be quite prominent” (Robbins)

Question 5

(+) CK7, CK19

(-) CK 20

Answer 5

pancreatic adenocarcinoma?

(+)CA 19-9

Question 6

RPGN

Answer 6

TYPE I: Goodpasteur
TYPE II: PSGN
TYPE III: microscopic polyangiitis
📌

Question 7

glomerulonephropathy assoc’d with heroin abuse

Answer 7

FSGS

LM: increased mesangial matrix, collapsed capillary loops, and hyalinosis

Question 8

LM: uniform, diffuse thickening of the capillary wall

Answer 8

membranous nephropathy

EM: subepithelial deposits along the GBM (spike and dome appearnce) and effacement of foot proccesses

Question 9

LM: extensive necrosis of tubules, primarily involving PCT with renal tubular cell casts in the distal tubules and collecting ducts

Answer 9

acute tubular necosis (ATN), toxic type

📌ischemic ATN

Question 10

Hematuria, left flank pain, left flank mass

biopsy: sheets of pale eosinophilic cells, often with perinuclear halo, with pervscular concentration of largest cells

Answer 10

chromophobe RCC

Question 11

Precursor lesiosn of urothelial carcinoma, invasive

Answer 11

non-invasive papillary urothelial carcinoma, high-grade

Question 12

solitary red, velvety plaque on the glans

Answer 12

undifferentiated PeIN (Bowen Disease)

may led to hPV-related squamous cell CA

Question 13

testiular tumor:
biopsy: large, polyhedral cells, with clear cytoplasm, central nuclei with one or two prominent nucleoli and stromal lymphocytic infiltrate

Answer 13

seminoma (classic)

IHC: CD117

Question 14

testiular tumor:

biopsy: sheets of highly anaplastic cells with numberous mitosis

Answer 14

embryonal carcinoma

(+)OCT 3, (-) KIT

Question 15

testicular teratoma in males

Answer 15

prepubertal: benign
postpubertal: malignatn

Question 16

why is S-100 requested in patient presenting with vulvar Paget disease

Answer 16

to rule out Melanoma

Question 17

Histopath of adenomyosis

Answer 17

gross: thickened myometria with blood lakes
microsections: endometrial stroma with glands in the deep myometrium

Question 18

cytologically typical spindle cells

Answer 18

leiomyosarcoma
IHC: (+) H-CALDESMON, smooth muscle actin (SMA)

IF WITH AREAS OF ENDOMETRIOID CARCINOMA
-Uterine carcinosarcoma with homologous sarcomatous element

Question 19

the most important differential diagnosis of bilateral ovarian involvement of a mucinous tumor

Answer 19

metastatic GIT carcinoma

Question 20

ovarian carcinomas associated with endometriosis

Answer 20

1. clear cell CA

2. endometrioid CA

Question 21

paraneoplastic syndrome of mature cystic teratoma

Answer 21

anti-NMDA encephalitis

patho: inflammatory limbic encephalitis

Question 22

hallmark of immature teratoma

Answer 22

neuroepithelial tissue

small, round, blue cells forming rosettes

Question 23

ovarian biopsy:

alternating areas of fibroblast-like cells and plumper spindle cells

Answer 23

fibrothecoma