Preseason 4 Flashcards
HbH disease
3 mutated genes for alpha thalassemia
Remarks on PNH
Flow cytometry: (-) CD55 and CD59 in almost 100% of red cells
Iron studies of anemia of chronic inflammation
Low Fe
Low TIBC
High ferritin
TTP’s pentad and ddx
Thrombocytopenia MAHA Acute renal failure Fever Altered mental status
DDX: HUS
HUS’ Quartet
Thrombocytopenia
MAHA
Acute renal failure
Bloody diarrhea / dysentery (from EHEC/shigella)
Destruction of air spaces mainly involving respiratory bronchioles with sparing of alveoli
Emphysema, centriacinar (pink puffers)
*barrel-chested
Lung honeycomb fibrosis
Usual interstitial fibrosis (UIP)
Post-CAP-HR
Biopsy: polypoid organizing connective tissue within alveolar spaces
Cryptogenic organizing pneumonia
Characteristic lesion: Masson bodies
Carbon-laden macrophages
Simple coal-workers pneumoconiosis (CWP)
Dust-laden macrophages
Silicosis
Case may present with TB
Pleural plaques
Asbestosis
Case may present with ancestral houses
What cells screte IFN-y
TH1 cells
If a tb patient has HIV with profoundly depressed CD4, what is expected
Marcophages with acid fast bacilli
Lung cancer
IHC: p40, p63 (+)
Squamous cell CA
Lung cancer
IHC: TTF-1, napsin A (+)
Invasive non-mucinous adenoCA
Lung cancer
IHC: synaptophysin, CD56 (+)
Small cell (Oat cell) carcinoma
Lung cancer
IHC: calretinin, CK5,6 (+)
Malignant mesothelioma
Case may present an old ancestral house
P16 (+)
HPV-related oropharyngeal SCC
- > 70% of the cellls should show diffuse and strong nuclear staining in order to be called positiv
- *HIV testing is only indicated in oropharyngeal SCC?
Soap bubble lesions in a mandibular mass
Ameloblastoma
Biopsy: nests of tumor cells with an outer layer of columnar cells with reverse polarity of nuclei, and an inner layer resembling stellate retinaculum
Schneiderian papilloma
Sinonasal papilloma, inverted type
Nasal septum
Biopsy: nests of cytologically benign squamous cellsinvaginating into the stroma of the mass
Biopsy findings of cholesteatoma
Stratified cytologically benign squamous cells with keratinous material
Remarks on thyroglossal duct cyst
Procedure; sistrunct procedure
Biopsy: unilocular cystic space lined by respiratory epithelium with few islands of thyroid follicles on the cyst wall
Mass on the inner side of the upper lip. Dx and biopsy?
Adenoid cystic carcinoma
Biopsy: gland-like structures showing cribriform pattern, lined by small cells with scant cytoplasm and yperchromatic compact nuclei
Gastric vs duodenal ulcer
Gastric ulcer
Gastric pH: increased
Duodenal ulcer
Gastric pH: decreased
Most common site of h pylori infection in the stomach
Antrum
Chromogranin A
Synapthophysin
Neuroendocrine cells
Elephant feet glands
Sessile serrated colonic polyp
Case: ascending colon
Biopsy: serrated architecture throughout the entire gland with lateral growth (elephant-feet glands), no dysplasia
Serrated architecture limited to the upper third of the gland
Hyperplastic polyp
Case: descending colon
Syndromes associated with FAP
GARDNER SYNDROME
Osteomas
Thyroid and desmoid tumors
Skin cysts
TURCOT SYNDROME
Medulloblastoma
Gliobalstoma
