Practice Questions Test 2 (Deck 5) Flashcards

1
Q

Which cells respond to chemotaxis?

A

Mostly granulocytes and monocytes

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2
Q

What is the main cell in acute inflammatory response?

A

Neutrophils

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3
Q

Neutrophils kill organisms by releasing what 3 substances?

A

ROI (free radicals)

Hydrogen peroxide

Lysosomal enzymes

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4
Q

Inflammatory cells rich in neutrophils are called

A

suppurative

and

purulent

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5
Q

There are NO neutrophils in birds. So what do birds have?

A

heterophils

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6
Q

Neutrophils contain _______ for killing

A

granules

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7
Q

Myeloperoxidase and gelatinase

are in granules in which cell of inflammation?

A

Neutrophils

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8
Q

Abundant in inflammatory diseases of immunologic, parasitic or allergic origin – Kill helminths via Ab-dependent cell -mediated cytotoxity

are characteristics of which type of inflammatory cell?

A

Eosinophils

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9
Q

What cell would you find

major basic protein in?

A

Eosinophils

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10
Q

Major basic protein, found in eosinophils, is strongly toxic to

_________

A

MBP is strongly toxic to

parasites

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11
Q

When released in tissues, __________ can cause degradation of collagen

A

Major basic protein in eosinophils

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12
Q

What are the major **chemoattractants **that are found in eosinophils?

A

Histamine

C5a

CCL5 and CCL11 (rantes and eotaxin, chemokines)

IL 4, 5, and 13

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13
Q

Summer sores in horses is a condition associated with what cell of inflammation?

A

Eosinophils

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14
Q

Pythiosis

is a condition associated with what inflammatory cell?

A

Eosinophils

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15
Q

Mast cell tumors

are associated with which inflammatory cell?

A

Eosinophils

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16
Q

Balanoposthitis

is a condition in horses associated with what inflammatory cell?

A

Eosinophils

17
Q

Eicosanoids are

_________ _________

metabolites

A

Arachidonic Acid

18
Q

What is the substance that can inhibit the activity of

eicosanoids?

A

Omega 3 Fatty Acids

19
Q

What are the 2 most important anaphylotoxins?

A

C3a and C5a

20
Q

What are the

4 most important pyrogens

associated with inflammation?

A

IL-1

TNF

IL-6

LPS

21
Q

Which pyrogen plays the biggest role in

fever?

A

IL-1

for fever

22
Q

The sustained production of this pyrogen

causes Cachexia

A

TNF

sustained production causes Cachexia

23
Q

COX-1 and COX-2

are

___________

derived from arachidonic acid

A

eicosanoids

24
Q

What does a Cox-2 inhibitor do?

A

blocks prostaglandins

25
Q

bradykinin, tachykinin, and substance P

are all plasma-derived from

which organ?

A

LIVER

ALL HAIL THE MIGHTY LIVER!!!

26
Q

T/F:

Substance P is a bradykinin

A

FALSE!

Substance P is a tachykinin

27
Q

What does C3b do to neutrophils?

A

C3b

INCREASES PHAGOCYTIC ACTIVITY

of neutrophils

28
Q

Macrophages are responsible for producing this important

pyrogen.

A

Macrophages produce

IL-1

29
Q

These are phagocytic cells that circulate in blood

A

monocytes

30
Q

These are phagocytic cells that reside in tissues

A

macrophages

31
Q

Which cells can produce granules?

A

Neutrophils

Eosinophils

Basophils

Mast Cells

32
Q

T/F:

Macrophages produce granules

A

FALSE!

Macrophages are mononuclear (agranular) and

only produce IL-1

33
Q

This very important kinin is responsible for pain signals, degranulation, histamine release, and implicated in

allergic and asthmatic reactions`

A

SUBSTANCE P!!!