Practice Questions Test 2 (Deck 5) Flashcards
Which cells respond to chemotaxis?
Mostly granulocytes and monocytes
What is the main cell in acute inflammatory response?
Neutrophils
Neutrophils kill organisms by releasing what 3 substances?
ROI (free radicals)
Hydrogen peroxide
Lysosomal enzymes
Inflammatory cells rich in neutrophils are called
suppurative
and
purulent
There are NO neutrophils in birds. So what do birds have?
heterophils
Neutrophils contain _______ for killing
granules
Myeloperoxidase and gelatinase
are in granules in which cell of inflammation?
Neutrophils
Abundant in inflammatory diseases of immunologic, parasitic or allergic origin – Kill helminths via Ab-dependent cell -mediated cytotoxity
are characteristics of which type of inflammatory cell?
Eosinophils
What cell would you find
major basic protein in?
Eosinophils
Major basic protein, found in eosinophils, is strongly toxic to
_________
MBP is strongly toxic to
parasites
When released in tissues, __________ can cause degradation of collagen
Major basic protein in eosinophils
What are the major **chemoattractants **that are found in eosinophils?
Histamine
C5a
CCL5 and CCL11 (rantes and eotaxin, chemokines)
IL 4, 5, and 13
Summer sores in horses is a condition associated with what cell of inflammation?
Eosinophils
Pythiosis
is a condition associated with what inflammatory cell?
Eosinophils
Mast cell tumors
are associated with which inflammatory cell?
Eosinophils
Balanoposthitis
is a condition in horses associated with what inflammatory cell?
Eosinophils
Eicosanoids are
_________ _________
metabolites
Arachidonic Acid
What is the substance that can inhibit the activity of
eicosanoids?
Omega 3 Fatty Acids
What are the 2 most important anaphylotoxins?
C3a and C5a
What are the
4 most important pyrogens
associated with inflammation?
IL-1
TNF
IL-6
LPS
Which pyrogen plays the biggest role in
fever?
IL-1
for fever
The sustained production of this pyrogen
causes Cachexia
TNF
sustained production causes Cachexia
COX-1 and COX-2
are
___________
derived from arachidonic acid
eicosanoids
What does a Cox-2 inhibitor do?
blocks prostaglandins
bradykinin, tachykinin, and substance P
are all plasma-derived from
which organ?
LIVER
ALL HAIL THE MIGHTY LIVER!!!
T/F:
Substance P is a bradykinin
FALSE!
Substance P is a tachykinin
What does C3b do to neutrophils?
C3b
INCREASES PHAGOCYTIC ACTIVITY
of neutrophils
Macrophages are responsible for producing this important
pyrogen.
Macrophages produce
IL-1
These are phagocytic cells that circulate in blood
monocytes
These are phagocytic cells that reside in tissues
macrophages
Which cells can produce granules?
Neutrophils
Eosinophils
Basophils
Mast Cells
T/F:
Macrophages produce granules
FALSE!
Macrophages are mononuclear (agranular) and
only produce IL-1
This very important kinin is responsible for pain signals, degranulation, histamine release, and implicated in
allergic and asthmatic reactions`
SUBSTANCE P!!!
