Practice Questions Test 2 (Deck 5)

Question 1

Which cells respond to chemotaxis?

Answer 1

Mostly granulocytes and monocytes

Question 2

What is the main cell in acute inflammatory response?

Answer 2

Neutrophils

Question 3

Neutrophils kill organisms by releasing what 3 substances?

Answer 3

ROI (free radicals)

Hydrogen peroxide

Lysosomal enzymes

Question 4

Inflammatory cells rich in neutrophils are called

Answer 4

suppurative

and

purulent

Question 5

There are NO neutrophils in birds. So what do birds have?

Answer 5

heterophils

Question 6

Neutrophils contain _______ for killing

Answer 6

granules

Question 7

Myeloperoxidase and gelatinase

are in granules in which cell of inflammation?

Answer 7

Neutrophils

Question 8

Abundant in inflammatory diseases of immunologic, parasitic or allergic origin – Kill helminths via Ab-dependent cell -mediated cytotoxity

are characteristics of which type of inflammatory cell?

Answer 8

Eosinophils

Question 9

What cell would you find

major basic protein in?

Answer 9

Eosinophils

Question 10

Major basic protein, found in eosinophils, is strongly toxic to

_________

Answer 10

MBP is strongly toxic to

parasites

Question 11

When released in tissues, __________ can cause degradation of collagen

Answer 11

Major basic protein in eosinophils

Question 12

What are the major **chemoattractants **that are found in eosinophils?

Answer 12

Histamine

C5a

CCL5 and CCL11 (rantes and eotaxin, chemokines)

IL 4, 5, and 13

Question 13

Summer sores in horses is a condition associated with what cell of inflammation?

Answer 13

Eosinophils

Question 14

Pythiosis

is a condition associated with what inflammatory cell?

Answer 14

Eosinophils

Question 15

Mast cell tumors

are associated with which inflammatory cell?

Answer 15

Eosinophils

Question 16

Balanoposthitis

is a condition in horses associated with what inflammatory cell?

Answer 16

Eosinophils

Question 17

Eicosanoids are

_________ _________

metabolites

Answer 17

Arachidonic Acid

Question 18

What is the substance that can inhibit the activity of

eicosanoids?

Answer 18

Omega 3 Fatty Acids

Question 19

What are the 2 most important anaphylotoxins?

Answer 19

C3a and C5a

Question 20

What are the

4 most important pyrogens

associated with inflammation?

Answer 20

IL-1

TNF

IL-6

LPS

Question 21

Which pyrogen plays the biggest role in

fever?

Answer 21

IL-1

for fever

Question 22

The sustained production of this pyrogen

causes Cachexia

Answer 22

TNF

sustained production causes Cachexia

Question 23

COX-1 and COX-2

are

___________

derived from arachidonic acid

Answer 23

eicosanoids

Question 24

What does a Cox-2 inhibitor do?

Answer 24

blocks prostaglandins

Question 25

**bradykinin, tachykinin, and substance P** are all plasma-derived from which organ?

Answer 25

**LIVER** **ALL HAIL THE MIGHTY LIVER!!!**

Question 26

T/F: Substance P is a bradykinin

Answer 26

FALSE! Substance P is a **tachykinin**

Question 27

What does **C3b** do to neutrophils?

Answer 27

**C3b** *INCREASES PHAGOCYTIC ACTIVITY* of neutrophils

Question 28

Macrophages are responsible for producing this important pyrogen.

Answer 28

Macrophages produce ## Footnote **IL-1**

Question 29

These are phagocytic cells that circulate in blood

Answer 29

monocytes

Question 30

These are phagocytic cells that reside in tissues

Answer 30

macrophages

Question 31

Which cells can produce granules?

Answer 31

Neutrophils Eosinophils Basophils Mast Cells

Question 32

T/F: Macrophages produce granules

Answer 32

FALSE! Macrophages are **mononuclear (agranular)** and only produce IL-1

Question 33

This very important **kinin** is responsible for pain signals, degranulation, histamine release, and implicated in allergic and asthmatic reactions`

Answer 33

**SUBSTANCE P!!!**