Practice Questions Test 2 (Deck 3) Flashcards
________ accumulations
are a manifestation of derangement in cells
Intracellular accumulations
Accumulations are attributed to what 4 types of abnormalities?
- Abnormal metabolism
- Defect in protein folding or transport
- Lack of an enzyme
- Ingestion of indigestible material
Fatty changes in the liver
and
Resorption Protein Droplets in Renal Tubules
are due to what abnormality?
Abnormal metabolism
Storage diseases like
**GM1 **and GM2 Gangliosidosis
are due to what type of abnormality?
Abnormality in
protein folding or transport
in the storage of lipids
Carbon particles and silica accumulate due to the lack of what?
The lack of an
enzyme
to degrade carbon and silica
Anthracosis is what type of accumulation?
TRICK!
It’s both types of accumulation
Intracellular AND Extracellular
Hepatocytes
Cardiac and Skeletal Muscle
and
Kidneys
are subject to accumulation by what substance?
Lipid accumulation
occurs in
Hepatocytes, Cardiac and Skeletal Muscle, and Kidneys
Glycogen is normally stored in variable amounts in 2 places. What are they?
Glycogen
stored normally in
Hepatocytes and Myocytes
Diabetes mellitus
is an example of a disease that is characterized by
accumulation of what substance?
Diabetes mellitus
Glycogen accumulation
Hyperadrenocorticism (steroid-induced hepatopathy)
is characterized by accumulation of what substance?
Hyperadrenocorticism (steroid-induced hepatopathy)
Glycogen accumulation
Pompe’s Disease
and
EPSSM (Equine Polysaccharide Storage Myopathy)
are examples of
_______ storage diseases
Pompe’s and EPSSM are
Glycogen storage diseases
Pompe’s Disease
is a glycogen storage disease that predisposes
Lapphunds, Shorthorn cattle, and Brahmin cattle
to a defective enzyme called _______.
GAA
is the defective enzyme in
POMPE’S Disease
What glycogen storage disease
affects the cardiomyocytes
and
peripherally displaces contractile elements?
Pompe’s Disease
EPSSM affects
Type ___ muscle fibers
like those in the
- Semitendinosus*
- and*
- Semimembranosus?*
EPSSM
Type 2 muscle fibers
Which glycogen storage disease
causes intracytoplasmic accumulations
of abnormal polsaccharides and subsarcolemmal
glycogen?
EPSSM
Protein accumulations are generally
intra________ accumulations.
Protein accumulations are
intracytoplasmic
If you see
Russell bodies (grapelike) and **Mott Cells **(plasma cells)
you have an intracellular accumulation of
_______
If you see
Russell bodies and Mott Cells
you have an accumulation of
PROTEIN
- Herpesvirus*
- Adenovirus*
and
Parvovirus
are DNA viruses that can cause intra________ accumulations
IntraNUCLEAR
A DNA virus that causes
Intracytoplasmic accumulations
Poxviruses
cause
intracytoplasmic accumulations
Negri Bodies
in Rabies
is an intra________
accumulation of viral proteins
Negri Bodies
are
Intracytoplasmic
What is an example of an RNA virus that can cause
both Intranuclear AND Intracytoplasmic
inclusion bodies?
Canine Distemper (Paramyxovirus)
BOTH accumulations
A systemic disease involving the
immune system and abnormal protein folding is called
Amyloidosis
In amyloidosis,
which protein is
Ig-Light-chain derived?
AL protein
is Ig Light Chain derived!
Which protein of amyloidosis is produced with
chronic inflammation?
AA protein
is associated with chronic inflammation amyloidosis
Ig Light Chain Derived Amyloidosis
(from plasma cells)
is
_______
in animals
UNCOMMON
What type amyloidosis do animals have?
Secondary amyloidosis
(Serum protein AA, Reactive system amyloidosis)
What breeds of dogs and cats are predisposed to
secondary amyloidosis of the familial type?
Dogs:
Beagles and Shapeis
Cats:
Abyssian, Siamese, and Oriental
What is the most common type of amyloidosis in domestic animals, but is RARE IN SWINE?
Familial amyloidosis
Black footed cats and Captive cheetahs
get this type of amyloidosis
Systemic amyloidosis
in black-footed cats
and
cheetahs
Idiopathic amyloidosis (AB-type)
is most common in
___________\_?
Idiopathic (ABt-type) amyloidosis
is most common in
older dogs
Most animals deposit kidney amyloids in their
glomeruli
with the exception of CATS
who deposit amyloids in their
___________
CATS
deposit amyloids in their
MEDULLAE
Where are most animals likely to deposit
amyloids in their livers?
In the Space of Disse in the liver
Amyloids in the spleen are located specifically in
the spleen’s ________ ________
Amyloids in the spleen are located specifically in
the spleen’s Germinal Centers
Amyloid deposits in the
Islets of Langerhaans
in the pancreas
is characteristic of what disease?
Diabetes mellitus
What is used to stain amyloids?
Congo Red and PAS
with the SH method
or
Lugol’s Iodine Stain of amyloid
Amyloidosis is a type of
___________ accumulation
EXTRACELLULAR
Fibrinoid change, Gout, and Chloesterol Crystal Clefts
are examples of
_____________ accumulations
Fibrinoid change, Gout, and Chloesterol Crystal Clefts
are examples of
EXTRACELLULAR accumulations
Tophi is the deposition of sodium urate crystals in tissues.
It is pathognomonic for what extracellular accumulation disease?
TOPHI
is pathognomonic for
GOUT
in birds and reptiles
Due to: Vitamin A deficiency, high protein diets, or renal injury
Cholesterol crystal clefts
are by-products of
__________
and
_________
Cholesterol crystal clefts
are by-products of
hemorrhage
and
necrosis
Cholesterol crystal clefts
are extracellular accumulations
that occur in what 2 diseases?
Cholesterol Crystal Clefts
occur in
Atherosclerosis and Choroid Plexus of Old Horses in Cholesteatomas
What is cholesteatomas?
An accumulation of
cholesterol crystal clefts in the choroid plexus of old horses
that obstruct the flow of CSF through the
intraventricular foramen
and cause
Hydrocephalus (sequelae)
