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RUSVM Pathology 3rd Semester > Practice Questions Test 2 (Deck 3) > Flashcards

Practice Questions Test 2 (Deck 3) Flashcards

1
Q

________ accumulations

are a manifestation of derangement in cells

A

Intracellular accumulations

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2
Q

Accumulations are attributed to what 4 types of abnormalities?

A
  1. Abnormal metabolism
  2. Defect in protein folding or transport
  3. Lack of an enzyme
  4. Ingestion of indigestible material
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3
Q

Fatty changes in the liver

and

Resorption Protein Droplets in Renal Tubules

are due to what abnormality?

A

Abnormal metabolism

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4
Q

Storage diseases like

**GM1 **and GM2 Gangliosidosis

are due to what type of abnormality?

A

Abnormality in

protein folding or transport

in the storage of lipids

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5
Q

Carbon particles and silica accumulate due to the lack of what?

A

The lack of an

enzyme

to degrade carbon and silica

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6
Q

Anthracosis is what type of accumulation?

A

TRICK!

It’s both types of accumulation

Intracellular AND Extracellular

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7
Q

Hepatocytes

Cardiac and Skeletal Muscle

and

Kidneys

are subject to accumulation by what substance?

A

Lipid accumulation

occurs in

Hepatocytes, Cardiac and Skeletal Muscle, and Kidneys

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8
Q

Glycogen is normally stored in variable amounts in 2 places. What are they?

A

Glycogen

stored normally in

Hepatocytes and Myocytes

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9
Q

Diabetes mellitus

is an example of a disease that is characterized by

accumulation of what substance?

A

Diabetes mellitus

Glycogen accumulation

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10
Q

Hyperadrenocorticism (steroid-induced hepatopathy)

is characterized by accumulation of what substance?

A

Hyperadrenocorticism (steroid-induced hepatopathy)

Glycogen accumulation

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11
Q

Pompe’s Disease

and

EPSSM (Equine Polysaccharide Storage Myopathy)

are examples of

_______ storage diseases

A

Pompe’s and EPSSM are

Glycogen storage diseases

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12
Q

Pompe’s Disease

is a glycogen storage disease that predisposes

Lapphunds, Shorthorn cattle, and Brahmin cattle

to a defective enzyme called _______.

A

GAA

is the defective enzyme in

POMPE’S Disease

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13
Q

What glycogen storage disease

affects the cardiomyocytes

and

peripherally displaces contractile elements?

A

Pompe’s Disease

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14
Q

EPSSM affects

Type ___ muscle fibers

like those in the

  • Semitendinosus*
  • and*
  • Semimembranosus?*
A

EPSSM

Type 2 muscle fibers

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15
Q

Which glycogen storage disease

causes intracytoplasmic accumulations

of abnormal polsaccharides and subsarcolemmal

glycogen?

A

EPSSM

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16
Q

Protein accumulations are generally

intra________ accumulations.

A

Protein accumulations are

intracytoplasmic

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17
Q

If you see

Russell bodies (grapelike) and **Mott Cells **(plasma cells)

you have an intracellular accumulation of

_______

A

If you see

Russell bodies and Mott Cells

you have an accumulation of

PROTEIN

18
Q
  • Herpesvirus*
  • Adenovirus*

and

Parvovirus

are DNA viruses that can cause intra________ accumulations

A

IntraNUCLEAR

19
Q

A DNA virus that causes

Intracytoplasmic accumulations

A

Poxviruses

cause

intracytoplasmic accumulations

20
Q

Negri Bodies

in Rabies

is an intra________

accumulation of viral proteins

A

Negri Bodies

are

Intracytoplasmic

21
Q

What is an example of an RNA virus that can cause

both Intranuclear AND Intracytoplasmic

inclusion bodies?

A

Canine Distemper (Paramyxovirus)

BOTH accumulations

22
Q

A systemic disease involving the

immune system and abnormal protein folding is called

A

Amyloidosis

23
Q

In amyloidosis,

which protein is

Ig-Light-chain derived?

A

AL protein

is Ig Light Chain derived!

24
Q

Which protein of amyloidosis is produced with

chronic inflammation?

A

AA protein

is associated with chronic inflammation amyloidosis

25
Q

Ig Light Chain Derived Amyloidosis

(from plasma cells)

is

_______

in animals

A

UNCOMMON

26
Q

What type amyloidosis do animals have?

A

Secondary amyloidosis

(Serum protein AA, Reactive system amyloidosis)

27
Q

What breeds of dogs and cats are predisposed to

secondary amyloidosis of the familial type?

A

Dogs:

Beagles and Shapeis

Cats:

Abyssian, Siamese, and Oriental

28
Q

What is the most common type of amyloidosis in domestic animals, but is RARE IN SWINE?

A

Familial amyloidosis

29
Q

Black footed cats and Captive cheetahs

get this type of amyloidosis

A

Systemic amyloidosis

in black-footed cats

and

cheetahs

30
Q

Idiopathic amyloidosis (AB-type)

is most common in

___________\_?

A

Idiopathic (ABt-type) amyloidosis

is most common in

older dogs

31
Q

Most animals deposit kidney amyloids in their

glomeruli

with the exception of CATS

who deposit amyloids in their

___________

A

CATS

deposit amyloids in their

MEDULLAE

32
Q

Where are most animals likely to deposit

amyloids in their livers?

A

In the Space of Disse in the liver

33
Q

Amyloids in the spleen are located specifically in

the spleen’s ________ ________

A

Amyloids in the spleen are located specifically in

the spleen’s Germinal Centers

34
Q

Amyloid deposits in the

Islets of Langerhaans

in the pancreas

is characteristic of what disease?

A

Diabetes mellitus

35
Q

What is used to stain amyloids?

A

Congo Red and PAS

with the SH method

or

Lugol’s Iodine Stain of amyloid

36
Q

Amyloidosis is a type of

___________ accumulation

A

EXTRACELLULAR

37
Q

Fibrinoid change, Gout, and Chloesterol Crystal Clefts

are examples of

_____________ accumulations

A

Fibrinoid change, Gout, and Chloesterol Crystal Clefts

are examples of

EXTRACELLULAR accumulations

38
Q

Tophi is the deposition of sodium urate crystals in tissues.

It is pathognomonic for what extracellular accumulation disease?

A

TOPHI

is pathognomonic for

GOUT

in birds and reptiles

Due to: Vitamin A deficiency, high protein diets, or renal injury

39
Q

Cholesterol crystal clefts

are by-products of

__________

and

_________

A

Cholesterol crystal clefts

are by-products of

hemorrhage

and

necrosis

40
Q

Cholesterol crystal clefts

are extracellular accumulations

that occur in what 2 diseases?

A

Cholesterol Crystal Clefts

occur in

Atherosclerosis and Choroid Plexus of Old Horses in Cholesteatomas

41
Q

What is cholesteatomas?

A

An accumulation of

cholesterol crystal clefts in the choroid plexus of old horses

that obstruct the flow of CSF through the

intraventricular foramen

and cause

Hydrocephalus (sequelae)

RUSVM Pathology 3rd Semester (12 decks)

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