PPQ3 Flashcards
Atropine is used for
Bradycardia caused by opioids; Reflex-bradycardia caused by alpha2-agonists (high BP);
AV-blocks & SA-blocks
ACP effects
Calming; Vasodilator; Depression of thermoregulation; Decreases BP; Antihistaminic;
Depression of platelet function
diazepam and midazolam
For old animals with poor general circulation; Decreases anxiety; Relaxes muscles;
High dose can caused respiratory depression
alpha 2 agonists
Sedative effect; Emetic; Antagonisable by atipamezole; Detomidine; Medetomidine;
Dexmedetomidine; Xylazine
medetomidine and xylazine
Using a general dose - phases of sedation, induction & maintenance cannot be
separated; Not recommended for old, cardiac & diabetic patients; Cause circulatory &
respiratory depression
opioid drugs
Major analgesics; Side effects are bradycardia & respiratory depression; Can be
antagonised by naloxone; Morphine; Fentanyl; Buprenorphine; Butorphanol
(Torbugesic); They all have differing levels of efficacy
opioid receptors
μ (Mu); k (Kappa); δ (Delta)
fentanyl
full agonist opioid drug; 15-30 minute duration of effect; may be redosed
morphine
Full agonist opioid drug; 4-6 hours duration of effect; Use high dose IV in mastocytoma
patients; Must not be redosed!
full opioid agonists
morphine; fentanyl
short duration of action
fentanyl
Partial μ-agonist
buprenorphine
Partial μ-antagonist & k-agonist
butorphanol
Weak μ-agonist
tramadol
propofol
Can be used in almost all patient groups; Short duration of action; Can be redosed;
High dose and rapid application lead to respiratory depression
application of propofol
slowly; IV; to effect
ketamine
Moderate analgesic effect; Benzodiazepines may help avoid catalepsy (muscle rigidity);
Eyes remain open, therefore the cornea may desiccate
safe inhalant anaesthetics
isoflurane, sevoflurane, desflurane
inhalant anaesthetics
1 MAC causes muscle relaxation in 50% of cases; 2 MAC causes muscle relation in
100% of cases; Short induction and recovery; Hypnotic; Muscle relaxant; No analgesic
effect
local anaesthetic
Blocks nerve cells; Types - Terminal, conductive, paravertebral, epidural & spinal;
Possible side effects – Cardiovascular & CNS signs, cell toxicity
Pancuronium; Atracurium; Vecuronium; Rocuronium
Central muscle relaxants; Peripheral depolarising muscle relaxants; Local anaesthetics
pain
Complex, multidimensional negative experience; No linear correlation between degree
of pathological changes and intensity of pain; Simultaneous nociceptive effects add up;
Function – Physiological or pathological; Origin – Organic or psychogenic; Duration –
Acute or chronic
pathological pain
Hyperalgesia: Mild noxious stimuli resulting in intense pain sensation; Allodynia: No
pain provocation, but pain sensation occurs; Analgesia can be combined; Pain impulse
may be inhibited by pain killers
ascending pathway of nociception
Transduction → Transmission → Modulation → Projection → Perception