Post-streptococcal glomerulonephritis Flashcards
1
Q
Post-streptococcal glomerulonephritis: cause
A
- weeks after groupA beta-hemolytic strep infection -> IgG/IgM-antigen complex deposits in glomerular basement membrane -> glomerulonephritis
2
Q
Post-streptococcal glomerulonephritis: S, C
A
- hematuria, proteinuria
- systemic symptoms: Fever, headache, malaise, anorexia, nausea
Complication -> renal failure
3
Q
Post-streptococcal glomerulonephritis: D
A
Antibodies against group A streptococcus:
- anti-DNase B antibodies
- anti-Streptolysin O antibody
.Light microscopy: mesangial proliferation
.electron microcopy: sub epithelial deposits (humps)
.immunufluroescence: deposits within GBM, mesangiyum (starry sky)
4
Q
Post-streptococcal glomerulonephritis: T
A
- supportive
