Acute tubulointerstitial nephritis

Question 1

Acute/chronic tubulointerstitial nephritis: general info

Answer 1

Acute or chronic tubulointerstitial nephritis -> are diseases resulting in primary injury to renal tubules and interstitium -> results in decreased renal function

Question 2

Acute tubulointerstitial nephritis: causes

Answer 2

• allergic drug reactions (70-90%), ex: antibiotics, NSAIDs

- infections

Question 3

Acute tubulointerstitial nephritis: signs and symptoms

Answer 3

• can be asymptomatics
• can result in systemic symptoms: fever, nausea, vomiting, lack of appetite etc…
• can cause flank pain, dysuria, hematuria, rash

Question 4

Acute tubulointerstitial nephritis: D

Answer 4

• physical examination
• blood test -> can show eosinophilia
• urinalysis -> eosinophiluria, hematuria, sterile pyuria, proteinuria

To confirm the diagnosis -> kidney biopsy
- interstitial edema and inflammatory infiltrates, blood vessels and glomeruli not affected

Question 5

Acute tubulointerstitial nephritis: T

Answer 5

• treat underlying cause