Lupus Nephritis

Question 1

Lupus Nephritis: cause

Answer 1

• antinuclear antibodies ( anti-dsDNA): bind to nuclear antigens, form antigen-antibody complexes -> deposits in capillary walls, basement membrane, Bowman’s space -> type III hypersensitivity reaction

Question 2

Lupus Nephritis: S, C

Answer 2

• Proteinuria +/-
• hematuria

Considered a nephrotic and nephritic syndrome, depending on the clinical stage of the disease

Complications:

• Renal vein thrombosis
• pulmonary embolism
• rapidly progressive glomerulonephritis

Question 3

Lupus Nephritis: D

Answer 3

depends Upton class

Question 4

Lupus Nephritis: T

Answer 4

• Prednisone
• mycophenolate
• cyclophosphamide