Minimal change disease

Question 1

Minimal change disease: cause

Answer 1

• Unknown; T cells release cytokines -> causes effacement of podocytes

More common in children, after infection, immunization, after taking NSAIDs

Question 2

Minimal change disease: S

Answer 2

• Proteinuria
  Rapid onset of symptoms compared to others

Complication: relatively benign -> does not affect kidney function

Question 3

Minimal change disease: D

Answer 3

• light microscopy: normal (why it’s called minimal changes)
• electron microscopy: effacement of foot processes
• immunofluorence: -

Question 4

Minimal change disease: T

Answer 4

• Prednisone