PLATELETDISORDER Flashcards
purplish red pintpoint
petechiae
hemorrhage of blood in the small areas of the skin
purpura
caused by leakage of small amount of flood in the tissue
ecchymosis
caused by leakage of large amount of flood around the puncture site
Hematoma
associated with increase platelet destruction
-platelets are large
Immunologic/ idiopathic thrombocytopenic purpura (TTP)
accumulation of ultra-large von willebrand factor due to the deficiency of the von willebrand factor cleaving preotease known as ADAMTS-13
non-immunologic/ thrombotic thrombocytopenic purpura
types of thrombocytosis
-reactive(secondary thrombocytosis
-autonomous thrombocytosis
moderately increase platelet for a limited time , usually asymptomatic
-to compensate , recovery from major surgery splenectomy
reactive (secondary) thrombocytosis
marked increase associated with thrombotic/ hemorrhagic complication
autonomous thrombocytosis
autonomous thrombocytosis is a typical finding in four chronic myeloproliferative disorder
CML
polycythemia vera
essential thrombocytemia
myelofibrosis