ERYTHROPOIESIS Flashcards
A major hormone produced by the kidney to stimulate erythropoiesis in the bone marrow
Erythropoietin
organ/s responsible for the production of EPO
80-90% Kidney (adult)
10-15% Liver (unborn/fetus)
how many days does it takes for the production of reticulocyte from pronormoblast
3-5 days
before being release in the circulation, the reticulocyte remain in the bone marrow for how many days
1-2 days
what are the two (2) identifiable progenitors
BFU-E
CFU-E
it gives rise to the earliest identifiable colony of RBCs
CFU-E
how many days does it take for the BFU-E to become a mature RBC
18-21 days
What are the stimulus for erythropoiesis to take place
Hypoxia (major stimulus)
Testosterone
it is a general term for RBC maturation series
Erythron
Maturation characteristics
- decrease cell size
- decrease nucleus
- decrease N:C ratio
- CCC chromatin pattern
- loss of nuclei
- loss of basophilia
it differentiate mature from immature RBCs
Chromatic pattern
what is the chromatic pattern for immature RBC
Fine and delicate 1
what is the chromatic pattern of mature RBC
Coarse, condensed, clumped
Characteristic of EPO
thermostable
nondialyzable
glycoprotien hormone
34kiloDalton
-earliest morphologically recognizable precursor
-most of the iron destined for hemoglobin synthesis is take into the cell at this stage
-N:C ratio 8:1
Rubriblast
pronormoblast
proerythroblast
