Chapter-10 Hemoglobin Metabolism

Question 1

the most studied proteins in the body due to the ability to easily isolate it from red blood cells (RBCs)

Answer 1

Hemoglobin

Question 2

the concentration of hemoglobin within RBCs

Answer 2

approximately 34 g/dl,

Question 3

Hemoglobins main function

Answer 3

Is to transport oxygen from the tissues and transport carbon dioxide from the tissues to the lungs for exhalation.

Question 4

heme consist of a ring of carbon, hydrogen, and nitrogen atoms called

Answer 4

protoporphyrin IX, carries a central ferrous Ion (Fe+2)

Question 5

oxidized hemoglobin is also called

Answer 5

Methemoglobin

Question 6

Alpha

Answer 6

141 #of amino acid

Question 7

beta

Answer 7

146

Question 8

gamma A

Answer 8

146 (position 136:alanine)

Question 9

Gamma G

Answer 9

146 (position: glycine)

Question 10

Delta

Answer 10

146

Question 11

Epsilon

Answer 11

146

Question 12

Zeta

Answer 12

141

Question 13

Theta

Answer 13

unknown

Question 14

refers to the amino acid sequence of the polypeptide chains

Answer 14

Primary structure

Question 15

refers to chain arrangements in helices and non helices

Answer 15

secondary structure

Question 16

refers to the arrangements of the helices into a pretzel-like configuration.

Answer 16

tertiary structure

Question 17

The predominant adult hemoglobin

Answer 17

Hb A, composed of two a-globin chains and
two b-globin chains. Strong a1–b1 and a2–b2 bonds hold the
dimers in a stable form. The a1–b2 and a2–b1 bonds are important for the stability of the quaternary structure in the oxygenated and deoxygenated forms

Question 18

Occurs in the mitochondria and cytoplasm
of bone marrow erythrocyte precursors, beginning with the
pronormoblast through the circulating polychromatic (also
known as polychromatophilic) erythrocyte

Answer 18

Heme biosynthesis

Question 19

it is where the production of globin chains takes place

Answer 19

erythroid precursors