Chapter 13- Platelet production, structure, and production

Question 1

non nucleated blood cells that circulate at 150 to 400x10^9/L

Answer 1

Platelets

Question 2

platelet count is slightly higher in women than in men and slightly lower in both sexes when over 65 yrs old

Answer 2

True

Question 3

a unique bone marrow cell where platelets arise

Answer 3

Megakaryocytes

Question 4

largest cells in the bone marrow and are polyploid, possessing multiple chromosome copies

Answer 4

Megakaryocyte

Question 5

megakaryocytes are found in the lungs

Answer 5

TRUE

Question 6

it is where the megakaryocytes progenitor arise, under the influence of the transcription gene product , GATA-1, regulated by cofactor FOGI

Answer 6

common myeloid progenitor

Question 7

From the common myeloid progenitor there arise three megakaryocyte lineage-committed progenitor

Answer 7

-Burst-forming unit (BFU-meg)
least mature
-Colony forming unit (CFU-Meg)
-LIGHT DENSITY CFU (LD-CFU-Meg)
most mature specific progenitor

Question 8

diploid and participate in normal mitosis, maintaining a viable pool of megakaryocytes progenitor

Answer 8

BFU-meg and CFU-meg

Question 9

third stage, loses capacity to divide but retains its DNA replication and cytoplasmic maturation

Answer 9

LD-CFU-Meg

Question 10

a partially characterized form of mitosis unique to megakaryocyte

Answer 10

Endomitosis