Plasmodium spp. II Flashcards
Plasmodium spp. - Infected Red Cell (size):
-P. vivax/P. ovale
- Enlarged (reticulocyte)
- Fimbriated (+/-; P ovale)
Plasmodium spp. - Infected Red Cell (size):
-P. malariae
Small to normal size
Plasmodium spp. - Infected Red Cell (size):
-P. falciparum
ALL sizes
Plasmodium spp. - Ring Form Trophozoite:
-P. vivax/P. ovale
Large
(>1/3 size of RBC)
*multiple infection not common
Plasmodium spp. - Ring Form Trophozoite:
-P. malariae (3)
- Thick
- Small (<1/3 RBC)
- “Birds eye” forms*
*chromatin dot appears to be detached in center of ring”
Plasmodium spp. - Ring Form Trophozoite:
-P. falciparum (5)
- Delicate
- Small (<1/3 RBC)
- 2 chromatin dots (+/-; “Headphones”)
- Applique forms
*Multiple infected RBCs common
Plasmodium spp. - Mature Trophozoite:
- P. vivax
- P. ovale
P. vivax:
-Large, Amoeboid form that fills RBCs
P. ovale:
- Comet form
- More compact than P. vivax
Plasmodium spp. - Mature Trophozoite:
-P. malaraie (3)
- “Band”/”Basket” forms
- Do NOT fill RBC
- Prominent Hematin pigment
Plasmodium spp. - Mature Trophozoite:
-P. falciparum
RARE in peripheral blood
Plasmodium spp. - Schizont (# of merozoites):
- P. vivax
- P. ovale
P. vivax:
>12 merozoites (12-24)
P. ovale:
>6 merozoites (6-14)
Plasmodium spp. - Schizont (# of merozoites):
-P. malariae
6-12 merozoites
-Surround clump of hematin pigment (“Rosette” form)
Plasmodium spp. - Schizont (# of merozoites):
-P. falciparum
RARE in peripheral blood
Plasmodium spp. - Gametocytes:
-P. vivax/P. ovale (2)
- Large
- Oval
Plasmodium spp. - Gametocytes:
-P. malariae
- Oval
- Fills RBC
Plasmodium spp. - Gametocytes:
-P. falciparum
Banana-shape
-Distorts RBC
Plasmodium spp. - Inclusions:
-P. vivax/P. ovale
Schuffner dots
-“Stippling”
Plasmodium spp. - Inclusions:
-P. malariae
NONE
Plasmodium spp. - Inclusions (gametocytes):
-P. falciparum
Maurer clefts
-Round to Comma-shaped red cytoplasmic dots
P. falciparum:
-Forms seen in peripheral blood
*what about the intermediate forms?
- RIng forms
- Gametozytes
*Erythrocytes with intermediate forms are sequestered in the capillaries of the liver, brain, heart and kidneys
P. ovale infected erythrocyte characteristics. (2)
- Oval (hence ovale)
- Fimbriated (+/-)
Mixed plasmodium spp. infections:
- Incidence
- Species
5%
-P. falciparum/P. vivax
Degree of parasitemia (% infected RBCs) is most important with what species?
- % considered severe
- Treatment effect
P. falciparum
- > 2% is severe
- Transient increase in parasitemia after treatment, followed by progressive diminution
