Pituitary Function & Failure Flashcards
anterior pituitary comes from what?
glandular/ectodermal cells hence vascular link
Posterio pituitary comes from what tissues?
outgrowth of brain hence neural link to hypothalamus
stalk of pituitary called?
infundibulum
posterior pituitary release?
- ADH/Vasopressin
2. Oxytocin
posterior pituitary hormones released from endings of what nerves?
supraoptic
paraventricular neurons
Anterior pituitary release?
FSH LH ACTH TSH Prolectin GH
what inhibits prolactin?
Dopamine (Prolactin inhibiting hormone)
Somatostatin does what?
inhibit GH
GnRH does what?
stims FSH and LH
ACTH acts on what?
adrenal cortex
corticotropin releasing hormone does what?
from hypothalamus and stims ACTH in anterior pituitary
What can inhibit CRH in its negative feedback loop?
ACTH and the Cortisol
What does somatomedin affect?
bone
soft tissue
LH does what?
sex hormone secretion:
estrogen/progesterone
testosterone
FSH stims?
gamete production
egg
sperm
hypothalamus is affected by what?
higher centres like sight, smell, etc.
limbic system
decreased protein binding could lead to what kind of endocrine disorder?
hypersecretion (more free hormone)
What is Kallmann syndrome?
embryology GnRH neurons fail to migrate
What is somatotropin?
GH
effects of GH compared to insulin?
increase blood fatty acid and glucose
GH half life?
18 minutes
what are somatomedins?
IGF 1 and 2 (poly peptide growth factor)
what hormone closes the epiphyseal plates of long bones?
estrogen
what is Laron dwarfism?
GH receptor insensitivity (liver)
chronic abuse or neglect can cause abonormal growth?
psychsocial dwarfism
