Adrenocortical Function/Dysfunction Flashcards
Does adrenal cortex and medulla form together?
Nope. different origin, fused during development
Adrenal cortex is what kind of gland? secretes what in general?
true endocrine gland
secretes steroids
adrenal medulla is what kind of gland? secretes?
modified sympathetic ganglion secretes neurohormones (catecholamines)
Adrenal cortex, which layers secrete what?
- Glomerulosa: Aldosterone
- Fasciculata: Glucocorticoids
- Reticularis: Sex hormomes
Glucocorticoids example?
Cortisol
ACTH from anterior pituitary is tropic to which regions in adrenal?
Fasciculata
Reticularis
Example of mineralocorticoid?
Aldosterone via RAAS and plasma K+
What is produced in reticularis?
Androgens
Estrogens
DHEA
What is dehydroepiandrosterone?
precursor to androgens
different steroids and chemically related which leads to?
cross over effects eg. cortisol and aldosterone
Cortisol negative feedback to:
ACTH
CRH
Cortisol does what to immune system?
suppresses
Cortisol does what to muscle?
protein catabolism
Cortisol does what to adipose tissue?
lipolysis
Cortisol does what to liver?
gluconeogenesis
CRH not just for cortisol, what else can it mediate?
inhibit appetite
signal labour via placenta
mood disorders
What does urocortin do?
brain neuropeptide that decreases appetite
POMC is a what?
large protein prohormone
POMC stands for?
pro-opiomelanocortin
What do you get from POMC in pituitary? 3 things
- ACTH
- y-lipotropin
- B-endorphin
What happens to ACTH processing in non-pituitary tissues?
creates a-MSH
What is a-MSH? what does it do? 3 things
melanocyte-stimulating hormone (melanocortins)
- melanin synthesis
- immune response
- decrease food intake