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Jason's Endocrine Block > Drugs Hypothalamo-pituitary > Flashcards

Drugs Hypothalamo-pituitary Flashcards

0
Q

2 hormones that stim GH?

A

Ghrelin

GHRH

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1
Q

what inhibits GH?

A

somatostatin

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2
Q

what hormone activates most actual growth?

A

IGF-1

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3
Q

What is growth hormone insensitivity?

A

liver won’t make IGF-1

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4
Q

what is growth hormone 2ndary deficiency?

A

pituitary is stuffed

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5
Q

what is growth hormone tertiary deficiency?

A

brain is not sending signals

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6
Q

what is somatotropin?

A

Growth Hormone

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7
Q

GH orally?

A

Nope. sucks. Parenteral admin

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8
Q

GH and T4?

A

can cause reduced T4 levels

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9
Q

Ghrelin and GHRH together does what?

A

synergize to release more GH

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10
Q

Ghrelin potential therapy for?

A

GH deficiency

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11
Q

IGF-1 replacement useful for what condition?

A

GH-insensitivity (Laron dwarfism)

anti-GH antibodies

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12
Q

IGF-1 side effects?

A

hypoglycaemia

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13
Q

Too much GH leads to?

A

Acromegaly

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14
Q

2 ways to reduce GH release?

A
  1. somatostatin analogue

2. dopamine agonist

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15
Q

what is pegvisomant?

A

GH antagonist

16
Q

what happens to somatostatin receptors upon activation? so what?

A

internalisation

useful for imaging

17
Q

somatostatin good reducer?

A

short half-life

18
Q

G120K-GH works how?

A

doesn’t have the glycine at 120 so interrupts site 2 binding

19
Q

what PEGylate something?

A

make it bigger, reduce renal filtration

20
Q

what does pegvisomant sacrifice to get?

A

sacrifice affinity to get increased exposure

21
Q

Hashimoto’s is what?

A

autoantibody destroys thyroid

22
Q

what does stable isotopes of iodine do?

A

protect against radioactive iodine via sheer competition

23
Q

Carbimazole does?

A

inhibit thyroid peroxidase

24
Q

propylthiouracil does what 2 things?

A
  1. inhibit thyroid peroxidase

2. prevent t4-t3 conversion

25
Q

Thioamines likely to cause what side effect?

A

hepatotoxicity

26
Q

HAlf life of T4?

A

7 days

27
Q

Why titrate T4?

A

heart is sensitive to it, could cause problems

28
Q

What is Liothyronine?

A

T3

29
Q

when use Liothyronine?

A

severe hypothyroid and myxoedema coma

30
Q

what is myxoedema?

A

long term hypothyroidism

31
Q

Cortisol does what to T3 and T4?

A

inhibits conversion of T4 to T3

32
Q

t3 inhibits what?

A

cortisol production

Jason's Endocrine Block (20 decks)

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