Drugs Hypothalamo-pituitary

Question 0

2 hormones that stim GH?

Answer 0

Ghrelin

GHRH

Question 1

what inhibits GH?

Answer 1

somatostatin

Question 2

what hormone activates most actual growth?

Answer 2

IGF-1

Question 3

What is growth hormone insensitivity?

Answer 3

liver won’t make IGF-1

Question 4

what is growth hormone 2ndary deficiency?

Answer 4

pituitary is stuffed

Question 5

what is growth hormone tertiary deficiency?

Answer 5

brain is not sending signals

Question 6

what is somatotropin?

Answer 6

Growth Hormone

Question 7

GH orally?

Answer 7

Nope. sucks. Parenteral admin

Question 8

GH and T4?

Answer 8

can cause reduced T4 levels

Question 9

Ghrelin and GHRH together does what?

Answer 9

synergize to release more GH

Question 10

Ghrelin potential therapy for?

Answer 10

GH deficiency

Question 11

IGF-1 replacement useful for what condition?

Answer 11

GH-insensitivity (Laron dwarfism)

anti-GH antibodies

Question 12

IGF-1 side effects?

Answer 12

hypoglycaemia

Question 13

Too much GH leads to?

Answer 13

Acromegaly

Question 14

2 ways to reduce GH release?

Answer 14

1. somatostatin analogue

2. dopamine agonist

Question 15

what is pegvisomant?

Answer 15

GH antagonist

Question 16

what happens to somatostatin receptors upon activation? so what?

Answer 16

internalisation

useful for imaging

Question 17

somatostatin good reducer?

Answer 17

short half-life

Question 18

G120K-GH works how?

Answer 18

doesn’t have the glycine at 120 so interrupts site 2 binding

Question 19

what PEGylate something?

Answer 19

make it bigger, reduce renal filtration

Question 20

what does pegvisomant sacrifice to get?

Answer 20

sacrifice affinity to get increased exposure

Question 21

Hashimoto’s is what?

Answer 21

autoantibody destroys thyroid

Question 22

what does stable isotopes of iodine do?

Answer 22

protect against radioactive iodine via sheer competition

Question 23

Carbimazole does?

Answer 23

inhibit thyroid peroxidase

Question 24

propylthiouracil does what 2 things?

Answer 24

1. inhibit thyroid peroxidase | 2. prevent t4-t3 conversion

Question 25

Thioamines likely to cause what side effect?

Answer 25

hepatotoxicity

Question 26

HAlf life of T4?

Answer 26

7 days

Question 27

Why titrate T4?

Answer 27

heart is sensitive to it, could cause problems

Question 28

What is Liothyronine?

Answer 28

T3

Question 29

when use Liothyronine?

Answer 29

severe hypothyroid and myxoedema coma

Question 30

what is myxoedema?

Answer 30

long term hypothyroidism

Question 31

Cortisol does what to T3 and T4?

Answer 31

inhibits conversion of T4 to T3

Question 32

t3 inhibits what?

Answer 32

cortisol production