physiology of the pulmonary system Flashcards

1
Q

what are the four steps involved in gas transport from atmosphere to the tissue

A
  • ventilation: inspired air to alveoli
  • external respiration: transfer from alveoli to capillary (diffusion)
  • Transport: gas transport in blood to tissue
  • internal respiration: exchange of gases between the capillary and tissue mitochondria
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2
Q

Circulation

A
  • passage of blood through the heart, blood vessels, organs and tissue
  • transport system
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3
Q

perfusion

A
  • refers to the blood flow at the capillary level
  • without this you get cyanotic
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4
Q

ventilation

A

mechanical movement of gas in and out of the lungs (getting to and from alveoli)

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5
Q

respiration

A
  • exchange of O2 and CO2 across a membrane at the cellular level
  • occurs via diffusion across a semipermeable membrane
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6
Q

compliance

A
  • a measure of the lungs ability to stretch and expand
  • COPD = high compliance
  • decreased compliance in restrictive pulmonary diseases
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7
Q

Elasticity

A
  • refers to the lungs ability to return to initial size after distension
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8
Q

Surfactant

A
  • a lipoprotein that REDUCES surface tension to keep alveoli open
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9
Q

Partial pressure

A
  • portion of the total pressure exerted by the presence of a single gas molecule
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10
Q

Neural control of breathing

A
  • automatic by pons (rate) and medulla (depth)
  • voluntary = cerebal cortex (integrates with singing, talking, laughing)
  • influenced by the hypothalamus (pH) and limbic system (emotion)
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11
Q

Vagus nerve and respiration

A
  • has stretch receptors to monitor when it is overstretched
  • irritant receptors to initiate coughing
  • j receptors
  • hiccups stem from stimulation of the vagus nerve
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12
Q

chemical control

A
  • chemoreceptors in the brainstem, peripheral arteries, carotids and aorta
  • sense changes in oxygen and carbon dioxide and pH
  • more sensitive to CO2 changes
  • feed into pons and medulla
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13
Q

when is dyspnea most likely to occur

A
  • when there is a discrepancy between neural drive to breathe and the level of ventilation achieved
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14
Q

Describe the pump handle and bucket handle effects

A
  • pump handle: refers to the up/anterior movement of the sterum and ribs
  • bucket handle: refers to the lateral movement of the rib cage
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15
Q

Mechanisms of inhalation

A
  • the diaphragm contracts and moves down
  • external intercostals contract lifting/rotating ribs, lift sternum and thoracic vertebrae
  • lungs stretch
  • pressure inside lungs is lower than pressure outside
  • air gets pulled into lungs
  • diaphragm pushes down into abdominal contents = abdomen expands
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16
Q

Mechanics of exhalation

A
  • lungs recoil
  • rib cage gets pulled inward
  • diaphragm gets pulled upward
  • pressure inside lungs is higher than pressure outside
  • air is forced out of respiratory tract
  • diaphragm no longer pushes abdominal contents
  • abdomen is pulled in
17
Q

TV

A
  • tidal volume
  • air inhaled and exhaled during quiet breathing
18
Q

IRV:

A

air that can be forcefully inhaled over normal breathing

19
Q

ERV:

A

air that can be forcefully exhaled over normal breathing

20
Q

RV:

A

the amount of air that cannot be forcefully exhaled

21
Q

Capacities:
TLC:

A

the total amount of air that the lungs can hold (IRV+TV+ERV+RV)

22
Q

IC:

A

maximum amount of air that can be inhaled following a normal expiration

23
Q

VC:

A

amount of air that can be forcefully exhaled following max inspiration

24
Q

FRC:

A

amount of air remaining in the lungs following a normal expiration

25
Q

Minute ventilation
- norms

A

= respiratory rate x tidal volume
- normal 4-6 L/min
- tidal volume can increase more than RR

26
Q

Describe pressures in the lungs during
1) resting
2) inspiration
3) expiration

A

1) atmospheric pressure = intrapulmonic pressure and intrapleural pressure is lower than atmospheric pressure
2) Atmospheric pressure>intrapulmonic pressure (air flows in) intrapleural pressure becomes more negative
3) atmospheric pressure <intrapulmonic pressure (air pushed out) intrapleural pressure remains negative

27
Q

Describe transport and cellular respiration

A
  • at alveoli: capillary Po2<alveoli Po2
  • at tissue: capillary Po2>tissue pO2
28
Q

Ventilation/perfusion ratio

A
  • Ratio of the amount of air entering the alveoli and the blood flowing available to the alveoli
  • Norm is 0.8 or greater
  • Alterations result in hypoxia
29
Q

Types of barriers in V/Q

A
  • dead space
  • shunt
30
Q

Dead space as a barrier

A
  • Air that does not participate in gas exchange
  • Ventilation but not perfuses
  • Anatomic dead space such as trachea and bronchi
  • alveolar/physiologic dead space: ex = pulmonary embolism that blocks blood flow to the lung
31
Q

Shunt as a barrier to V/q

A
  • Blood flow that returns to the left side of the heart without picking up oxygen
  • Perfused but not ventilated
  • Pneumonia (lung has gunk in it and get clogged so gas does not diffuse as well)
32
Q

V/Q in relation to body position

A
  • Air and pulmonary blood flow are related to gravity
  • Body position has a significant effect on the distribution of pulmonary blood flow
  • Greatest volume of pulmonary blood flow will occur in gravity dependent areas of the lungs
  • More in the bases than apices in upright position
  • Patients that are bed bound need to be put in different positions to use different portions of their lungs → we normally change positions throughout our day