Physiology Flashcards
RMP of nerve fiber is …..
RMP is due to ….
RMP is close to isoelectric potential of …..
-70mv
Potassium ions
Chloride ions
Inhibitory post synaptic potential /IPSP is due to ….
Main constituent of cell membrane is…..
Fluidity of cell membrane is increased by…..
Chloride influx
Protein
Polyunsaturated FA
RBC membrane has……
Basement membrane contains (3)
Spectrin ( maintain integrity)
Laminin
Nidogenin
Type 4 collagen
Synthesis of lipids are in……cell organelle
Synthesis of proteins are in ……cell organelle
Smooth ER
Rough ER
Cell organelle that maintain
Cell shape:
Catabolism of H2O2
Microtubules
Peroxisome
Marker of
Mitochondria
Golgi bodies
Plasma membrane
Glutamic dehydrogenase
Galactosyl transferase
Adenyl cyclase 5 nucleotidase
Measurement of total body water (2)
Titrated water
Deuterium oxide
Measurement of ECF (2)
Measurement of plasma volume (2)
Inulin , mannitol
Evans blue
Radiolabeled albumin
Normal anion gap -value
9-15 mmol/l
Cations-anions
- Band which narrows during contraction
- Active sites of actin are covered by….
- Essential for smooth muscle contraction ….
H band and I band
Tropomyosin
Cellular Calcium
- Golgi tendon organ detects ….
- Impulses are transmitted by …
- Golgi tendon reflex is …..
- Muscle tension
- Type 1b nerve fibers
- Bisynaptic
- Muscle spine is a receptor for…..
- Peripheral zone of muscle spindle has…
- Myotactic/ stretch reflex
- Actin and myosin
Most resistant vessel is….
Gas exchange vessel is….
Arterioles
Capillaries-most surface area
Bp formula
Conditions with falsely high Bp (3)
COx TPR
Small cuff
Thick walled vessels
Obesity
Define EDV
Value
Determines …..
Volume of blood present in ventricular cavity at end of atrial contraction.
Value: 130-150ml
Determines preload
Define stroke volume
Formula
Value.
Volume of blood ejected with each heart beat
CO/HR
70-80ml
Define ejection fraction
Ratio of stroke volume /EDV
Value of cardiac index
Formula
3.2
CO/ BSA
Blood flow is mainly controlled by…..
Effect of CO2 on brain vessels
- Arterioles
- Vasodilation
3rd heart sound is heard during …..
Early ventricular filling phase -stretching of chordae tendinae
Y wave of JVP is due to….
Opening of AV valve (tricuspid) and emptying blood into ventricle
CO2 is primarily transported in arterial blood as ….
Normal value of PO2 is…
Bicarbonate
80-100mmhg
Arterial level of Co2 is….
During inspiration, intrapleural pressure becomes …..
40mmHg
More negative :(- 6mmHg )
Define total lung capacity
Volume of air contained in the lungs at the end of maximum inspiration
Total lung capacity depends on…
Define vital capacity ; value.
Lung compliance
Amount of air that can be forced out of lung after maximal inspiration.
Value: 4.8L
Define tidal volume, value.
Amount of air breathed in or out during normal breathing
Value: 500-750ml
Functional residual capacity; define
Define physiological dead space ; value
Volume of air left in lungs after normal expiration.
Anatomic+ alveolar dead space
155ml-male, 120ml-female
Define expiratory reserve volume
Volume of lung at the end of quiet expiration-which can be expired with maximal effort.
Value of minute alveolar ventilation
Response to high altitude (3)
3.5-4.5L
- Increased ventilation (earliest)
- Increased response to carotid bodies
- Respiratory alkalosis
Increased pulmonary capillary pressure results in….
Surfactant production is accelerated by…
Pulmonary edema
Glucocorticoids
What is Nerst equation?
Bicarbonate diffuses into plasma
Same quantity chloride diffuses into RBC in venous circulation.
AKA chloride shift.
What is heads paradoxical reflex?
Inflation of lungs induces more inflation
Pneumotaxic centre is present in….
Sickle cell hemoglobin shift O2 dissociation curve to ….
Respiratory distress syndrome shift the curve to….
Upper pons (dorsal)
Right
Right
Factors stimulating renin secretion (2)
Hypotension
Hyponatremia
Major part of glomerular filtrate is absorbed in…
Substances completely reabsorbed in PCT(2)
PCT
Glucose
Amino acids
In the presence of vasopressin , maximum reabsorption of water takes place in…
Substances partially absorbed in PCT (3)
PCT
- Sodium
- Bicarbonate
- Water
Macula densa is …..
Epithelial lining of thick ascending loop of henle close to afferent arteriole.
Tubuloglomerular feedback is mediated by sensing …..
Loop of henle does not handle…
Filtration fraction is calculated as ….
Nacl in densa
Urea
GFR/RPF =20%
Normal GFR is….
Normal creatinine level is…
Urea clearance is….
125ml/min
0.6-1.2mg
88ml/min
Action of gastrin (2)
- Stimulates secretion of gastric juice
- Increases gastric motility
Action of secretin (3)
- Stimulates secretion of watery,alkaline,and pancreatic secretion.
- Inhibit gastric secretion
- Causes contraction of pyloric sphincter
CCK-PZ secretion is stimulated by ….
Gastric secretion is stimulated by..(2)
Gastric phase of gastric secretion is mediated by ….
1 proteins
2. Gastrin, histamine
- Hormones
- Intestinal motility is stimulated by (2)
- Fat is maximally absorbed in…
- Calcium is maximally absorbed in….
- Distension, Ach
- Jejunum
- Proximal intestine
- Electrolytes are absorbed in…
- Effect of dietary fibers (eg: pectin) (2)
- Colon
- a) increase bulk in stool
B) increase metabolism of sugar in GIT
Largest reserve of energy in body
Gastric lipase helps in digestion of …
Indicator of malabsorption
Fat
Fat
Fat in stool ->6gm/day
Insulin increases …(3)
- Protein synthesis
- Fat synthesis
- Glucose synthesis
In fetus, secretion of insulin begins at …..
Insulin secretion is inhibited by……
3 months
Epinephrine
Hormones acting on intracellular nuclear receptors (3)
- Steroids
- Thyroid hormone
- Vitamin D
CAMP mediates action of …(2)
Effect of PTH (2)
ADH
PTH
- Stimulates osteoclastic activity
- Augments absorption of calcium from the gut
Effect of calcitonin (3)
- Opposite to that of PTH
- Lowers serum calcium
- Acts by decreasing osteoclasis (bone resorption)
PTHrP is ……factor
Feature of PTHrP is…
Hypercalcemic
Important hormonal mediator of cancer associated hypercalcemia
Active form of calcium is in…..
A decrease in concentration of free calcium ions in plasma results in…(2)
Ionized form
- Increased neuromuscular irritability and tetany
- Chvostek sign
ECG finding of hypercalcemia
Hormones increased in stressful condition (4)
Prolong QT interval
- Adrenaline
- Vasopressin
- Cortisol
- Glucagon
In darkness activity of ……….is increased
Serotonin-N-acetyl transferase
Functions of LH (2)
- Stimulates ovulation
- Maintains corpus luteum
FSH receptors are present in …..
Capacitation occurs in ….
I’m female genital tract ,sperm don’t survive more than……hrs
Granulosa cells
Female genital tract
48 hrs
4-7Hz are called …..waves found in…..
3-5 Hz are called ……
Theta waves , hippocampus
Delta waves
Theory for color vision
Visibly range electromagnetic spectrum of human eye ….
Helm Holtz theory
370-740nm
Function of amacrine cells
Regulates relative color and luminosity of photoreceptive input under changing light.
Most sensitive pathway for stimulus of color contrast
Parvocellular pathway from lateral geniculate body-to visual cortex
Blobs of visual cortex are associated with…
Function of pacinian corpuscles
Color processing
Senses rapidly adapting touch,pressure,vibration
Region of CNS, which degenerate in Huntington’s disease
Caudate nucleus
Cingulate gyri and amygdaloid nucleus are part of …..
Wernicke’s aphasia is …..
Limbic system
Impaired comprehension of spoken and written language
- Broca’s aphasia is concerned with …..
- Nuclei of hypothalamus controlling shivering
- Nuclei of hypothalamus controlling thirst and water balance
- Word formation
- Posterior hypothalamus
- Supraoptic nuclei
Functions of hypothalamus (3)
- Food intake
- Hypophyseal control
- Non shivering thermogenesis -because of noradr, mediated by beta3 receptors
Hormone important for cold adaptation
Main excitatory neurotransmitter of CNS
Thyroxine
Glutamate
Flight or fight response include (3)
- Increased HR
- Increased Bp
- Increased TPR
Functions of neocerebellum
Function of basal nuclei/basal ganglia
Planning and programming of voluntary movements
Programming of movements
Caudate nucleus and lentiform nuclei are part of ….Brain structure
NO is AKA….
NO has half life of….
Basal ganglia
EDRF
4 secs (short t1/2)
NO acts as …(3)
Histamine is formed by …
- Free radical
- Vasodilator
- Oxidizing agent
Decarboxylation of histidine
Function of histamine
Effect of release of ANP (4)
Mediates triple response
- Excrete sodium and water(augment GFR)
- Inhibit sodium reabsorption in PCT
- Arteriolar and venous dilation (by antagonizing vasoconstrictors)
- decrease Bp
ANP acts by ….
Changes seen with exercise (3)
CGMP pathway
- Increases cardiac output
- Increased RR
- Blood flow to brain-unaltered
Changes with aging (2)
Vital capacity decreases
Hct remains same
Trypsinogen is converted to trypsin by …..
Renin is secreted by …..
Enterokinase
JG cells
- % gastric juice secreted in gastric phase
- Renin acts on which protein
- 50-60%
- Angiotensinogen
- Alveoli are kept dry due to ….
- Define bell megendie law
- Surfactant
- Principle that spinal cord dorsal roots are sensory and central roots are motor.