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Pathology Flashcards

1
Q

Dystrophic calcification occurs in ……tissues

Calcium level in dystrophic calcification is….

A

Dying tissues

Normal

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2
Q

What is red infarct? Where does it occur?

A

Venous occlusion seen in organ with dual blood supply

Gut

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3
Q

Mc type of necrosis

Features of irreversible injury (4)

A

Coagulative necrosis

  1. Flocculent,large amorphous densities in mitochondria —> increased mitochondrial permeability.
  2. Swelling and disruption of lysosomes and autolysis
  3. Nuclear degradation
  4. Plasma membrane damage
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4
Q

Features of apoptosis (3)

A
  1. Condensation of nuclear chromatin followed by fragmentation
  2. Formation of cytoplasmic/ membrane blebs
  3. Phagocytosis of apoptotic cells
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5
Q

Phagocytosis is inhibited by ….

Egs of autoimmune diseases (3)

A

Bcl2

  1. SLE
  2. Graves’ disease
  3. Myasthenia gravis
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6
Q

Gamma gandy bodies are seen in…..

A

Chronic venous congestion of spleen - sickle cell anemia

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7
Q

Leukotrienes which cause vasoconstrictions

LTB4 causes ….

A

LTC4,D4,E4

Adhesion of WBC

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8
Q

Prostaglandins inhibit…..in coagulation pathway

C5a is important in…..

A

Platelet aggregation

Chemotaxis

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9
Q

Wound contraction is mediated by …..

Epitheloid and multinucleated giant cells are derived from ….

A

Fibroblast

Monocyte-macrophages

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10
Q

ARDS/ diffuse alveolar damage is also known as….

Lines of Zahn are seen in ……

A

Shock lung

Thrombus

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11
Q

Chicken fat clot is ….

Procoagulant states (2)

A

Post mortem thrombus

  1. Protein C & S deficiency
  2. Factor 5/ Leiden mutation
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12
Q

Hyperviscosity seen in …(2)

A

Cryoglobinemia
Multiple myeloma

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13
Q

MHC is located on chromosome…..

Cells that are a part of innate immunity

A

6

NK cells

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14
Q

NK cells are expressed on …..

NK cells kills …..&…….cells

A

CD16,CD 56

Infected and cancer cells

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15
Q

Killing by NK cells is …..

A

MHC independent-not dependent on foreign Ag presentation

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16
Q

Translocations for burkitt lymphoma (2)

A

t(8:14), t(8:22)

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17
Q

Translocation for CML
Ewing sarcoma

A

t(9:22)

t(11:22)

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18
Q

Tumor marker for
1. Endodermal sinus tumor
2. Yolk sac tumor

  1. Pancreatic Neuroendocrine tumor
  2. Ca cervix
A
  1. AFP
  2. AFP
  3. Gastrin
  4. Keratin
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19
Q

Hypersensitivity reaction of PK/ prusnitz reaction

Casoni’s test

A

Type 1

Type 1

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20
Q

Hypersensitivity for schick’s test

A

Type 3- immune complex mediated

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21
Q

Egs of type 2 hypersensitivity reactions (5)

A
  1. ITP
  2. Immune haemolytic anemia
  3. Blood transfusion reaction
  4. Good pasteurs syndrome
  5. Graves’ disease (type 5)
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22
Q

Light microscopy of amyloidosis

A

Enlarged tubular basement membrane

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23
Q

Common types of amyloidosis (3)

A

Systemic
Localised
Hereditary

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24
Q

Types of systemic amyloidosis (3).

A
  1. Primary amyloidosis
  2. Secondary amyloidosis
  3. Dialysis related amyloidosis
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25
Q

Types of localised amyloidosis (5)

A
  1. Alzheimer’s disease
  2. Type 2 DM
  3. Medullary carcinoma thyroid
  4. Isolated atrial amyloidosis
  5. Systemic senile amyloidosis
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26
Q

Types of hereditary amyloidosis (2)

A
  1. Familial amyloid cardiomyopathy
  2. Familial amyloid polyneuropathy
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27
Q

Fibril protein of primary amyloidosis and seen in …..

A

AL Ig light chains
Seen in multiple myeloma

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28
Q

Fibril protein of secondary amyloidosis and seen in ….(4)

A

Serum amyloid A (AA)

Seen in chronic If conditions:
1. IBD
2. Familial Mediterranean fever
3. Rheumatic arthritis
4. Protracted infection

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29
Q

Fibril protein in dialysis related amyloidosis

Fibril protein of Alzheimer’s disease and pathology

A

Beta 2 microglobin

B amyloid protein
Cleaved amyloid precursor protein (APP)

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30
Q

Fibril protein of type 2 DM and pathology

A

Islet amyloid polypeptide
Caused by deposition of amylin in pancreatic islets

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31
Q

Fibril protein in Medullary carcinoma thyroid

Protein in isolated atrial amyloidosis
Seen in ….. risk of ….

A

Calcitonin

ANP
Seen in normal aging
Increased risk of Atrial fibrillation

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32
Q

Amyloid protein deposited in systemic senile amyloidosis
Seen predominantly in …..

A

Normal Wild type transthyretin TTR

Cardiac ventricles

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33
Q

Mutated transthyretin gene is seen for ….(2)

A
  1. Familial amyloid cardiomyopathy
  2. Familial amyloid polyneuropathy
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34
Q

Manifestations of amyloidosis (6)

A
  1. Cardiac: Restrictive cardiomyopathy
  2. G.I: macroglossia, hepatomegaly
  3. Renal : nephrotic syndrome
  4. Hematology: easy bruising, splenomegaly
  5. Neurology: neuropathy
  6. MSK : Carpal tunnel syndrome
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35
Q

5% African Americans are carriers of …..amyloidosis

A

Familial amyloid cardiomyopathy

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36
Q

Most common site of amyloidosis

Best dx method for amyloidosis

A

Kidney —-> Liver

Abdominal fat biopsy > Rectal biopsy

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37
Q

Congo red stain in ordinary light gives …

Expression of homocysteinuria

A

Pink colour

Autosomal recessive

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38
Q

Expression of VWD

Expression of retinoblastoma

A

AD

AD

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39
Q

Expression of hereditary spherocytosis

Chromosome 3 is involved in ….
Chromosome 4 is involved in …..

A

AD

Renal cell carcinoma

Huntington’s chorea

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40
Q

Chromosome 7 is involved in …..

Gene for folate carrier protein is located on ….

A

Cystic fibrosis

Chromosome 21

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41
Q

Gene regulating morphogenesis

APC is located on ….

BRCA1 is located on …
BRCA2 is located on ….

A

Homeobox genes (HOX)

Chromosome 5

Chromosome 17
Chromosome 13

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42
Q

First Ab to be synthesised after exposure to new Ag

First ab to be synthetized by fetus

Ab that fixes complement

A

IgM

IgM

IgM

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43
Q

Ig mediating reaginic hypersensitivity

IFN alpha is produced by …..
IFN beta is produced by ….

A

IgE

Leukocytes
Fibroblasts

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44
Q

IFN produced by T lymphocytes and NK cells

Edward syndrome is trisomy ….
Patau syndrome is trisomy ….

A

IFN gamma

18

13

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45
Q

Complement for opsonisation

Complement for chemotaxis

A

C3 b

C5 a

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46
Q

Most abundant collagen of human body is ….

Gene for von hipple lindau disease

A

Type 1

VHL gene - tumour suppressor

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47
Q

Rb gene is a tumour suppressor for …(2)

A

Retinoblastoma
Osteosarcoma

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48
Q

BRCA is tumour suppressor for ….

Medium sized vessels arteritis includes (2)

A

Hereditary breast carcinoma

PAN
Kawasaki disease

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49
Q

Esr of 100 is seen in ….

Pathological feature of malignant hypertension

A

Temporal arteritis

Fibrinoid necrosis

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50
Q

Hyaline arteriosclerosis is seen in ….

Pseudo aneurysm/ false aneurysm is seen in ….

A

Benign HTN

Hematoma - does not contain all 3 layers of arterial wall

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51
Q

Valves least involved in RHD

Earliest change seen in MI

A

Tricuspid valve & pulmonary

Waviness of fibers

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52
Q

Change noticed within 1-3 days of MI

Scarring in MI is complete by …..

A

Granulation tissue

3 months

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53
Q

Charcot layden crystals are seen in …..

Curschmann spirals are seen in ….

A

Asthma

Asthma

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54
Q

Test used for sarcoidosis

Features of sarcoidosis (3)

A

Kveims test

  1. End stage lung disease in 15-30% cases
    60-70% recovers
  2. Non caseating sarcoid granuloma
  3. Does not involve brain
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55
Q

Condition which may mimic sarcoidosis

Egg shell calcification pattern seen in ….

Intense fibrosis is a pathological feature of ….

A

Berylium inhalation

Silicosis

Mesothelioma

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56
Q

Particle size dangerous for pneumoconiosis

A

Smaller than 1 micron

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57
Q

Squamous cell esophageal cancer is related to ….(5)

A
  1. Smoking
  2. Alcohol
  3. Chronic achalasia
  4. Plummer Vinson syndrome
  5. Tylosis
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58
Q

Virus causing esophagitis (3)

A
  1. HSV1 & 2
  2. Varicella zoster
  3. CMV
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59
Q

GIST/ gastrointestinal stromal tumors are expressed on …(2)

A

CD117 & CD 34

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60
Q

Features of Gardner syndrome (4)

A
  1. Rectal and colonic polyposis
  2. Skin cysts
  3. Osteomas
  4. Dentigerous cysts
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61
Q

Features of peutz jegherz syndrome (2)

A
  1. Hamartomatous polyps of GIT
  2. Mucocutaneous pigmentation
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62
Q

Features of von recklinghausen disease (2)

A

Generalised neurofibromatosis
Cafe au lait pigmentation

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63
Q

Genetic predisposition for celiac disease (2)

A

DQ2,DQ8

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64
Q

Typhoid ulcers are (3)

A
  1. Longitudinal
  2. Ulceration of peyers patches
  3. Stricture is rare
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65
Q

Pipe stem colon is seen in….disease

Mc site of involvement in Crohn’s disease

A

Ulcerative colitis

Ileum

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66
Q

Mallory bodies are composed of …

Mallory bodies are seen in….(2)

A

Eosinophilic intracytoplasmic inclusions

  1. Primary biliary cirrhosis
  2. Alcoholism
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67
Q

Mallory hyaline is absent in ..(2)

A
  1. Secondary biliary cirrhosis
  2. Hepatitis
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68
Q

Acute infection of HBV ….positive (2)

Mc cause of sporadic cases of hepatitis in adults

A
  1. HbsAg+
  2. IgM antiHBc +

HEV

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69
Q

Angiosarcoma of liver is associated with …(2)

A
  1. Vinyl chloride
  2. Aflatoxin
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70
Q

Flea bitten kidney is seen in …(2)

A
  1. Malignant HTN
  2. Acute PSGN
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71
Q

Contracted kidney is seen in ..(2)

A
  1. Chronic GN
  2. Chronic pyelonephritis
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72
Q

AntiGBM ab seen in ….disease

Diffuse involvement is seen in ….

A

Goodpasteurs syndrome

PSGN

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73
Q

Sub epithelial humps seen in ….

FSGN having worst prognosis…..

A

PSGN

Collapsing variety

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74
Q

Subepithelial spikes is a feature of …

What are the crescents in RPGN?

A

Membranous GN

Epithelial cells+ fibrin + macrophage

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75
Q

Alports syndrome features (3)

A
  1. Hereditary nephritis
  2. Nerve deafness
  3. Eye disorders : anterior lenticonus
    Dot and fleck retinopathy
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76
Q

Lung involvement in wegeners granulomatosis

A

B/L modular cavitary infiltrates- showing necrotising granulomatous vasculitis

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77
Q

Renal biopsy in wegeners granulomatosis is that of …..

A

Pauciimmune necrotising and crescentic GN

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78
Q

B/L renal cell cancer may be seen in …..

Finnish type of nephritic syndrome is due to ……

A

Von Hippel Lindau disease

Mutation of nephron

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79
Q

Mc gene defect in steroid resistant nephritic syndrome is …..

Papillary thyroid cancer spread by ….

A

NPHS2

Lymphatics

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80
Q

Histology feature of papillary thyroid cancer

Hurthle cell cancer is a variant of ….

A

Orphan annie eyed nuclei

Follicular cancer of thyroid

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81
Q

Helmet cells are seen in ….(2)

A
  1. HUS
  2. Coombs positive
82
Q

Bite cells are seen in ….

Schistocytes are seen in …..

A

G6PD

Acquired spherocytosis

83
Q

Ring sideroblasts are ….

A

Iron granules in mitochondria around nucleus

84
Q

Tear drop poikilocytosis seen in …(2)

A
  1. Myeloid metaplasia
  2. Myelofibrosis
85
Q

Post splenectomy histology changes includes (2)

A
  1. Howell Jolly bodies
  2. Heinz bodies
86
Q

Burr cells are seen in ….

Acanthocytes are seen in ….

A

Uraemia

Chronic liver disease
Post splenectomy

87
Q

Spur cells are seen in …..

Sickle cell anemia causes ….

A

Chronic liver disease

Structurally abnormal Hb

88
Q

Basically hereditary spherocytosis is a ….

Proteins defective in HS (3)

A

Cell membranes defect

Ankyrin
Paladin
Anion transport protein

89
Q

Causes of aplastic anemia (2)

A
  1. Drugs: chloramphenicol
  2. Virus
90
Q

Feature absent in aplastic anaemia

Most effective treatment of aplastic anemia is ….

A

Splenomegaly

Bone marrow transplant

91
Q

Conditions associated with AML (2)

Features of AML (2)

A

Down’s syndrome
Bloom syndrome

Chloroma
Auer rods

92
Q

AML subtype which is not positive for nonspecific esterase

AML with gum infiltration

93
Q

Acute promyelocytic leukemia is associated with ….
Translocation is …..

A

DIC
t( 15:17)

94
Q

B cell neoplasms include (2)

A
  1. Hairy cell leukaemia
  2. Mantle cell lymphoma
95
Q

Histology of multiple myeloma (2)

Labs of MM (2)

A

Russel bodies and flame cells

Urea level raised
Bence jones proteins

96
Q

Associated feature of hairy cell leukaemia

DOC of hairy cell leukaemia

A

Splenomegaly

Cladribine

97
Q

Malignant cells of Hogkins lymphoma are…

RS cells are positive for ….(2)

A

RS cells

  1. CD15, CD 30
98
Q

Subtype of hogkins lymphoma which is not postive for CD15,CD 30.

Hogkins lymphoma with hilar LAD

A

Lymphocytic predominance

Nodular sclerosis

99
Q

Mc type of Hogkins lymphoma

Mc type of Hogkins lymphoma in India

A

Nodular sclerosis

Mixed cellularity

100
Q

Mc site of extranodal non-Hogkins lymphoma

Starry sky appearance is seen in ….

A

Stomach

Burkitt’s lymphoma

101
Q

Features of anti phospholipid antibody syndrome (2)

A
  1. Arterial / venous thrombosis
  2. Recurrent fetal loss 2nd trimester
102
Q

Lab findings of anti phospholipid antibody syndrome (2)

A

Prolonged APTT
Normal PT

103
Q

Complex granular corpuscles are produced by …..

CSF findings of pyogenic meningitis (2)

A

Microglia

  1. Increased protein
  2. Decreased sugar
104
Q

Mc primary brain tumour

Mc brain tumour in adults

Mc posterior fossa Tumor in children:

A

Glioma

Secondaries

Cerebellar (pilocytic) astrocytoma

105
Q

Pseudo-rosette is seen in …..(2)

Enamel like structure is found in …..

Glial fibrillary proteins are seen in ….

A

Neuroblastoma
Retinoblastoma

Craniopharyngioma

Astrocytoma

106
Q

Mc site of berry aneurysm

Histology of Alzheimer’s disease (2)

Pick bodies are seen in ….

A

Anterior circle of willis

Hirano bodies
Neurofibrillary tangles

Pick disease

107
Q

Mc B/L breast tumour

Mc tumors of ovary

A

Lobular cancer

Primary epithelial tumors ( cystadenoma, clear cell cancer)

108
Q

Reinke’s crystals are seen in ….

Conditions associated with germ cell tumours of testes (2)

A

Hilus cell tumour

Cryptoorchidism
Testicular feminization syndrome

109
Q

GCT associated with klinefilters syndrome

Seminoma corresponds to …..

A

Medullary GCT

Dysgerminoma of ovary

110
Q

Window period of HIV

A

Time between infection and detection of ab of HIV

111
Q

Hallmark of HIV (2)

A
  1. Profound immunodeficiency
  2. Quantitative and qualitative deficicency of helper or inducer T cells
112
Q

AIDS related neoplasm (3)

A
  1. Kaposi sarcoma
  2. B cell NonHogkin lymphoma
  3. Primary lymphoma of brain
113
Q

Kaposi sarcoma arises from …..

Kapoks sarcoma is associated with (2)

A

Blood vessels

HIV
Immunosuppression/organ transplant

114
Q

HLA A3 is associated with …..

HLA B8 is associated with ….

A

Hemochromatosis

Addisons disease
Myasthenia Gravis
Graves’ disease

115
Q

HLAB27 is associated with

A

PAIR
Psoriatic arthritis
Ankylosing spondylitis
IBD arthritis
Reactive arthritis

116
Q

HLA associated with psoriasis

117
Q

HLA Dr2 is associated with (4)

A

Multiple sclerosis
Hay fever
SLE
Good Pasteur syndrome

118
Q

Hashimotos thyroiditis is associated with HLA…

Addisons disease is associated with HLA

A

DR 3,5

B8,DR3,4

119
Q

conditions of DR 3 (4)

A

SLE
DM type 1
Hashimotoz
Addisons

120
Q

Conditions of DR 4 with HLA (3)

A

Rheumatoid arthritis
DM type 1
Addisons disease

121
Q

Pathology of coagulation necrosis

A

Arterial obstruction - type of cell necrosis dealing with obstruction/slow blood flow- leading to ischemia

122
Q

Malignancy of breast is likely to be associated with which type of microscopic appearance of breast tissue

Mc tumor of appendix

A

Atypical epithelial hyperplasia

Argentaffinoma

123
Q

Infective endocarditis is not seen with which heart condition

Wilms Tumor gene is located on chromosome….

A

ASD

Chromosome 11

124
Q

Feature of adult CML but not juvenile CML

Intracranial tumor having good prognosis in children

A

Philadelphia chromosome is positive

Cerebellar astrocytoma

125
Q

Sustained severe HTN in children is most common suggestive of …..

Mc posterior mediastinal tumor is ….

A

Renal parenchymatous disease

Neurofibroma

126
Q

Characteristic feature of kidney in DM

A

Diffuse glomerulosclerosis

127
Q

Irreversible cell injury is demonstrated by

Poorly differentiated carcinoma expresses which tumour marker

A

Amorphous large densities in mitochondria

Cytokeratin

128
Q

Marker of small cell carcinoma of lung

Cause of Edema in nephritic syndrome

A

Chromogranin

Salt and water retention

129
Q

Klatskin tumor is another term for ….

Burkitts lymphoma is positive for Cd…

A

Cholangiocarcinoma

CD 19

130
Q

HMB45 is used as a marker for …

Creola bodies are seen in …

A

Malignant melanoma

Asthma

131
Q

Lardaceous spleen is seen in ….

Transverse ulcers in GIT are seen in which infection …

A

Amyloidosis

TB

132
Q

Pulmonary artery is not involved in ……vasculitis

Loss of intercellular connections between cells is known as ….

A

Churg Strauss syndrome

Acantholysis

133
Q

Duchenne muscular dystrophy is a ……protein defect

Takayasu arteritis does not affect which arteries

A

Sarcolemmal

Coronary artery

134
Q

Pneumoconiosis as a result of prolonged cotton dust inhalation

Necrotising papillitis is seen in ….(3)

A

Bysinnosis

DM
Sickle cell anemia
Analgesic nephropathy

135
Q

Oral hairy leukoplakia is caused by ….virus

Antihistone Ab are associated with ….

A

EBV

Drug induced lupus

136
Q

Histology of measles

Stain for reticulocytes

A

Warthin Finkeledy cells

Brilliant cresyl blue

137
Q

Endoscopes are sterilised by ….

Biological transmission shown by filariasis

A

2% glutaraldehyde

Cyclodevelopmental

138
Q

Procalcitonin ( amyloid protein) is associated with …..

Acanthocytes in peripheral smear are seen in ….

A

Medullary carcinoma of thyroid

Abetalipoproteinemia

139
Q

Mc type of acute bacterial endocarditis

Herring bodies are seen in ….

A

Staph aureus

Neurohypophysis
Herring bodies are Neurosecretory vesicles where oxytocin and ADH are released prior to release.

140
Q

Mc site of left atrial myxoma

Fibrous plaques are composed of ….

A

Fossa ovalis

Smooth muscle cells, fibrous tissue

141
Q

Fibrous cap in atheroma contains…

Storage organelles in von willibrand factor found in endothelial cells

A

Smooth muscle cells and collagen

Weibel Palade bodies

142
Q

Subungual fibromas are seen in …

Stain used to identify viable myocardium in myocardial injury

A

Psoriasis

TTC- triphenyl tetrazolium chloride

143
Q

Amyloid tissue produces mahogany brown stain with ….

Amyloid produces apple green birefringence due to ….

A

Iodide and sulphuric acid

Cross beta pleated configuration of amyloid fibrils

144
Q

Myelin figures are formed during …..

Hutchinson’s secondaries in skull are due to tumours of which gland?

A

Necrosis

Adrenal

145
Q

Mc site of gastrinoma in werner syndrome

Least common cause of calcification in lung is ….

A

Small intestine

Amyloidosis

146
Q

Hypersensitivity vasculitis is seen in which part of vascular system

Which factor is responsible for cardiac hypwrtrophy?

A

Post capillary venules

C-myc

147
Q

Features of silicosis on cut section of lung (2)

A

Palpable nodules in early stages
Hard collagenous scar in late stages with pleural thickening

148
Q

Earliest feature of TB is proliferation of ….

Asteroid bodies are seen in ….

A

Lymphocytes

Sarcoidosis

149
Q

Metastatic calcification most often seen in …

Pneumonia alba caused by ….

A

Lungs

Treponema pallidum

150
Q

APUD cells are seen in which tumour of lung

Content of Mallory hyaline (2)

A

Bronchial carcinoid

Cytoskeleton intermediate filaments
Prekeratin

151
Q

Gall bladder thickening with comet tail on USG s/o ….

A

Adenomyomatosis of gall bladder

152
Q

Marrow in iron deficiency anemia (2)

A
  1. Normoblastic
  2. Deficient reticuloendothelial iron stores
153
Q

Tissue thromboplastin activates which factor

Increased PT and normal PTT are seen in deficiency of which clotting factor

A

Factor 7

Factor 7

154
Q

Addition of glucose to stored blood prevent …

Periglomerular fibrosis is considered typical of ….

A

Hemolysis

Chronic pyelonephritis
Any chronic renal diseases- periglomerular fibrosis is fibrosis of glomeruli due to lack of blood supply.

155
Q

Increased C3NF associated with which glomerulonephritis

Onion peel appearance of splenic capsule is seen in ….

156
Q

Systemic miliary TB occurs when spread of infection occurs through which route

Regeneration of liver after partial hepatectomy is an eg of ….

A

Arterial

Hyperplasia

157
Q

Optic nerve meningioma arises from which meninges

Mc primary malignant bone tumor is ….

A

Arachnoid

Multiple myeloma

158
Q

Rb gene is located on which chromosome

Eg of transcription factor

A

Chromosome 13q14

MYC

159
Q

Mx inheritance of retinitis pigmentosa

Leptocyte in blood smear are seen in ….

A

Sporadic

Thalassemia

160
Q

CD marker for MALT lymphoma

Staining used in dx in Hirschsprung disease

A

CD 20

AchE

161
Q

Immune mediated complexes is which type of necrosis

Ann Arbor classification is used for ….

A

Fibrinoid necrosis

Hogkins lymphoma

162
Q

Donath Landsteiner test is used in dx of ….

A

Paroxysmal cold hemoglobinuria

163
Q

Characteristic of whipples disease

Characteric labs of FSGN (2)

A

Foamy macrophage

IgM , C3

164
Q

In type 1A maple syrup urine disease, gene mutation is seen in ….

Dent disease is due to defect of ….

A

E1a

Chlorine channel

165
Q

Cyclin D and IGH fusion gene is associated with ….

Mc cause subtype of hepatitis B in north India

A

Mantle cell carcinoma

ayw

166
Q

Isolated rise in aPTT is seen in ….

Harlequin icthyosis is inherited as ….

A

Antiphospholipid Ab

AR

167
Q

Multifactorial inheritance is most likely to result in …..disorder

HLA marker of Behçet’s disease

A

Cleft lip

B51

168
Q

CD marker of langerhans histiocytosis

In which disease is IL-6 persistently raised

A

CD 1 a

Behçet’s disease

169
Q

Burkitt lymphoma is positive for CD ….

Which gene is responsible for mutation in hepatitis B virus ?

A

CD 20

C gene

170
Q

Use of cryoprecipitate

Mutation in Gs-alpha may lead to which disease

A

Afibrinogenemia

Mc cune Albright syndrome

171
Q

Pseudo-pelger huet cells are found in…

Mc encountered mutation in carcinoma prostrate

A

Myelodysplastic syndrome

GPST 1

172
Q

Which substance leads to resolution of Inflammation? (3)

A
  1. TNF alpha
  2. IL-10
  3. IL-1 receptor antagonist
173
Q

Necrotising arteriolitis with fibrinoid necrosis is found in ….

Cystic medial necrosis with necrotising arteritis is found in ….

A

Ag-ab mediated

Aortoarteritis

174
Q

Anemia with reticulocytosis is seen in ….

Carcinoid heart disease affects which part of heart

A

Haemorrhage

Valvular endothelium

175
Q

In atherosclerosis, foamy cells contain lipid in the form of ….

Cellular infiltrates seen in late pseudomonas infection

A

Oxidized LDL

Neutrophils

176
Q

Mc site for adenoid cystic carcinoma

Which tumor has consistency and appearance of grape like cluster ?

A

Minor salivary glands

Embryonal rhabdomyosarcoma

177
Q

Characteristic peripheral blood picture in megaloblastic anemia (2)

Dx of falciparum malaria is made by ….

A

Macrocytosis
Decreased reticulocyte count

PfHRP-2

178
Q

Enzyme alpha-naphthyl esterase is present in ……cell

Primary membranous Nephropathy has antibodies against ……

A

Monocyte

Phospholipase A2

179
Q

TNF and IL-1 are produced by ……

EBV receptor located on surface of B cell is …..CD

A

Activated macrophages

CD 21

180
Q

Increased prothrombin time results from deficiency of which molecule

Thymic hypoplasia is associated with which syndrome

A

Fibrinogen

Myasthenia Gravis

181
Q

Cleft like space in atheromatous plaque contains …..

Characteristic histopathology finding in whipped disease (2)

A

Cholesterol crystal

  1. PAS positive macrophages
  2. Rod shaped bacilli in lamina propria
182
Q

Mc cause of inherited peripheral neuropathy

Flow cytometry is done to know….

A

Charcot Marie tooth disease

Rapid cell shrinkage

183
Q

Sequence of events in acute inflammation

A

Transient vasoconstriction —-> vasodilation—->increased permiability—->stasis

184
Q

Mc part of body involved in multiple myeloma

Absence of lamina dura is seen in …….

A

Bone marrow

Hyperparathyroidism

185
Q

Mc cause of iodine deficiency in India

Diabetic foot ulcer is commonly associated with ……

A

Autoimmune hypothyroidism

Microangiopathy

186
Q

Most specific marker for gastrointestinal stromal tumor

Apoptosis is directly regulated by …..

A

CD117

Cytochrome C

187
Q

Aneuploidy is due to ……

Dystrophic calcification is seen in ……

A

Nondisjunction at meiosis

Atheromatous plaques

188
Q

Feature of COPD

Not a component of Werner’s syndrome

A

Amyloidosis

Adrenals

189
Q

Malignancy in pheochromocytoma is indicated by ….

An autosomal dominant condition is ……

A

Metastasis

Huntingtons chorea

190
Q

Mc premalignant condition of oral carcinoma

Benzene therapy causes ….

A

Leukoplakia

AML

191
Q

An important factor for chronic pyelonephritis is ……

Hormone Not a cause of increased capillary permeability

192
Q

False for renal amyloidosis

A

Renal amyloidosis commonly presents with HTN

193
Q

Protein not decreased in nephrotic syndrome

Property of protective epithelium

A

Fibrinogen

Regenerative power

194
Q

Cyclic changes in women breast consists of ….

Dx feature of rheumatic heart disease

A

Epithelial cell proliferation

Aschoff bodies

195
Q

Most commonly defective antibody in multiple myeloma

Most common organ associated with poly cystic disease

196
Q

In which condition, ubiquitin gets deposited in neurons

Residual body is defined as …..

A

Huntingtons chorea

Lysosome with undigested particle inside

197
Q

FLIP is which type of gene

Type of necrosis seen in omentum

A

Antiapoptotic

Fat necrosis

198
Q

Which type of amyloid protein is raised in ankylosing spondylitis

HLA associated with paoriasis vulgaris

A

Serum amyloid associated protein

HLA Cw6

199
Q

Most prominent cells in rheumatic arthritis

A 55 year male presented with dry mouth and rheumatoid arthritis, Dx with minor salivary gland tumour. Earliest histological finding is …..

A

Lymphocytes

Lymphocyte

200
Q

Most common epithelial stomach tumor is ….

Underlying process of TB

A

Adenocarcinoma

Hypersensitivity reaction with modified macrophages,lymphocytes, and giant cells

201
Q

A 55 year old smoker underwent mass resection from bronchus. Most useful immunohistochemical marker to make proper dx is …..

Bio marker for follow up of granulosa cell tumour of ovary

A

Cytokeratin

Inhibin

202
Q

Increase in bleeding time seen in ….

Neet Pg (11 decks)

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