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Dermatology Flashcards

1
Q

Skin is …….epithelium

Correct sequence of cell cycle

A

Stratified squamous keratinised

G0-G1-S-G2-M

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2
Q

2 layers of stratum germinativum/ Malpighian layer

A

Basal cell layer-melanocytes are present
Prickle cell layer/ stratum spinosum

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3
Q

Stratum lucidum is a …..cell layer. Present only in …..

A

Clear cell layer
Palms and soles

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4
Q

Stratum corneum is ……cell layer

A

Most superficial
Horny cell layer

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5
Q

Define acantholysis. Seen in…..

A

Loss of coherence between epidermal cells
Seen in pemphigus

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6
Q

Pterygium of nail seen in ……

Onycholysis is seen in ……

A

Lichen planus

Psoriasis

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7
Q

Oil drop, pitting of nails seen in ….

Tinea unguium affects …..

A

Psoriasis

Nail plate

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8
Q

Koenen’s periungual fibroma seen in …..

A

Tuberous sclerosis

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9
Q

Pinta is caused by …..

Yaws is caused by ….

A

Treponema carateum

Treponema pertenue

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10
Q

Scabies Incubation period is …..

Pathognomonic lesion of scabies is …..

A

4 weeks

Burrows

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11
Q

Layer of skin where scabies are formed ….

Mc site of scabies in infants : ……(2)

A

Stratum corneum

Scalp and face

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12
Q

Most infectious form of scabies

Drug used orally for scabies

A

Norwegian scabies

Ivermectin

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13
Q

Psoriasis is most commonly seen on …..

What is koebners phenomenon ?

A

Extensor aspect

Traumatised lesions develop psoriatic lesion - at the site of injury

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14
Q

KP is seen in …..(4)

A
  1. Psoriasis
  2. Lichen planus
  3. Lichen sclerosis
  4. Vitiligo
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15
Q

Histopathological lesion in psoriasis. Seen on …layer of skin

A

Munro microabscess- St corneum

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16
Q

Severe form of psoriatic arthritis

A

Arthritis mutilans - pencil cup deformity in X-RAY

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17
Q

What is auspitz sign?

Rx of choice for psoriasis.

A

Rubbing of skin to remove scales lead to pin point bleeding

PUVA

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18
Q

Antibodies of pemphigus are against …..
Attacks ….

Feature of pemphigus (2)

A

Intercellular substance
Desmoglein 3

  1. Intraepidermal (flaccid) acantholytic bullae
  2. Oral mucosal lesion
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19
Q

Definitive dx of pemphigus

A

Demonstration of antidesmoglein antibodies by direct immunoflorescence on skin biopsy

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20
Q

Tense subepidermal bullae are seen in …..

Hailey hailey disease is also known as ….

A

Pemphigoid

Familial benign pemphigus

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21
Q

Feature of hailey hailey disease

Features of lichen planus (4)

A

No subepidermal blistering

  1. Flat topped/plain
  2. Papules
  3. Pruritic
  4. Purple color
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22
Q

Histological features of lichen planus (2)

Basal cell shows …..

A

Civatte bodies and wickham’s striae

Vacoular degeneration

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23
Q

Feature of lichen planus in oral mucosa

Terms associated with pityriasis rosacea (2)

A

White lacy markings on mucosa

  1. Herald patch
  2. Annular collarette of scales
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24
Q

What are dermatophytes? It involves….

A

Parasitic fungus/ mycosis that infects the skin
Imperfect fungi of genera-epidermophyton,microsporum,trichophyton

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25
Q

Dermatophytes are ….
Where do they infect? Why?

A

Anamorphic- asexual/imperfect

Skin,hair,nails due to their ability to obtain nutrients from keratinised material

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26
Q

Athletes foot is aka ……
Feature

A

Tinea pedis
1. Severe itching
2. Hyperhydrosis

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27
Q

Onchyomyosis is aka…..
Affects ….

A

Tinea unguium/ ringworm of nail
Affects nail plate

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28
Q

Tinea versicolor caused by …..
It is a ……organism
Rx

A

Malassezia furfur
Dimorphic lipophilic

Ketoconazole and itraconazole are systemic therapy

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29
Q

Comedones are …..(4)

A
  1. Small cysts
  2. Formed in hair follicles
  3. Due to blockage of follicular orifice
  4. By retention of sebum and keratinous material
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30
Q

Acne vulgaris is caused by …..

Atopic dermatitis is aka…

A

Obstruction of pilosebacous duct

Itch disease

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31
Q

Childhood and adolescent pattern of atopic dermatitis is marked by (2)

A
  1. Flexural skin dermatitis
  2. Particularly in antecubital fossa/popliteal fossa
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32
Q

Other features of atopic dermatitis (3)

A
  1. Perioral pallor
  2. Dennies Morgan Fold- extra fold of skin beneath eyelid
  3. Increased palmar markings
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33
Q

Best test to dx atopic dermatitis

Basal cell carcinoma of skin spreads …..

A

Clinical evaluation

Direct spread

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34
Q

Conditions predisposing to squamous cell carcinoma of skin (2)

A
  1. Actinic keratosis
  2. DLE
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35
Q

Mycosis fungoides is AKA…..

Special features (3)

A

Cutaneous T cell lymphoma

  1. Mc skin lymphoma
  2. Pautrier’s microabscess
  3. Presents with diffuse erythroderma
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36
Q

Dermatitis herpetiformis is associated with …..

HLA of dermatitis herpetoformis (2)

A

Gluten sensitive enteropathy

HLA-DRw3
HLA-DQw2

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37
Q

Direct immunoflorescence of normal appearing perilesional skin in DH shows ….

DOC of dermatitis herpetiformis

A

Granular deposits of IgA

Dapsone

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38
Q

Mc endocrinology cause of acanthosis nigricans

Internal malignancy associated with acanthosis nigricans (2)

A

Type 2 DM

Adenocarcinoma lungs
Carcinoma GIT

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39
Q

Pseudopelade alopecia is aka …..(2)

Causes of cicatricial alopecia (4)

A

Cicatricial alopecia
Scarring alopecia

Lichen planus
Discoid lupus erythromatosis
Lupus vulgaris
SLE

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40
Q

Alopecia areata is AKA…

……..is characteristic

A

Non-cicatricial/ non scarring alopecia

Exclamation mark sign

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41
Q

Clinical presentation of alopecia areata (4)

A
  1. Single or multiple circumscribed smooth patchy hair loss
  2. Most obviously on scalp, but frequently involving any hair bearing skin like beard, eyebrows, eye lashes.
  3. Pathognomonic exclamation mark
  4. “ Going gray overnight” phenomenon
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42
Q

Alopecia areata is rx by …..

DOC for herpes zoster
DOC for acyclovir resistant cases

A

Minoxidil

Acyclovir/ famciclovir
Foscarnet

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43
Q

Skin features of secondary syphilis (3)

A
  1. Periostitis
  2. Rashes
  3. Moth eaten alopecia
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44
Q

Leprosy associated with …..cells

Rx of nerve abscess in leprosy

A

Virchow cells

I&D

45
Q

Mc nerve involved in leprosy

Organs not involved in leprosy (4)

A

Ulnar nerve
1. Ovary
2. Lungs
3. CNS
4. Axilla

46
Q

Mc type of leprosy in India

Lepromin test indicates ….

A

TT

Strong immunity

47
Q

Define lucio phenomenon

A

Cutaneous ulcerations in patients with lepromatous leprosy

48
Q

Features of lepromatous leprosy (3)

A

Gynecomastia
Madarosis
Collapse of nasal bridge

49
Q

Histology of lepromatous leprosy

A

Dermis contains characteristic highly vacoulated cells -foam cells

50
Q

Type 2 ENL reaction is …..hypersensitivity reaction. Rx.

A

Type 3
Thalidomide is effective

51
Q

Type 1 hypersensitivity reaction is ……type of hypersensitivity reaction. Rx

A

Type 4
Corticosteroids

52
Q

Light generated in wood’s lamp

Wood’s lamp filter is made of ……

A

360nm UV/ black light

Barium silicate glass containing 9% nickel oxide

53
Q

Appearance of erythrasma in wood’s lamp is……

Lupus vulgaris is ……

A

Coral red colour

Skin TB with no underlying active focus

54
Q

Tb of lymph node is called ….

Form of post primary TB with good resistance

A

Scrofuloderma

Tb verrucosa cutis -tb bacillus inoculated into skin.
Seen in TB patients, pathologists, veterinary surgeons

55
Q

Skin diseases of staph aureus (3)

A
  1. SSSS
  2. Bullous impetigo/ impetigo contagiosa
  3. Furuncles/boils
56
Q

Reiters syndrome is secondary to ….(2)

A
  1. Chlamydial infection- genital tract
  2. Infectious dysentery -
    Caused by : shigella
    Salmonella
    Ureaplasma urealyticum
57
Q

Features of reiters syndrome (3)

A
  1. Urethritis
  2. Conjunctivitis
  3. Arthritis - ascending asymetric oligoarthritis
58
Q

Features of tuberous sclerosis (3)

A
  1. Ash leaf spots
  2. Adenoma sebaceum
  3. Shagreen patches
59
Q

Darriers sign seen in …
Pinch purpura seen in …..

A

Urticaria pigmentosa

Amyloidosis

60
Q

Calcinosis cutis seen in …..

Crocodile skin seen in…..

A

Scleroderma

Ichthyosis

61
Q

Iris pearls seen in ….

Asboe Hansen sign seen in ….

A

Leprosy

Pemphigus

62
Q

Dubios sign seen in …..

Ollendroff sign seen in ….

A

Congenital syphillis

Secondary syphilis

63
Q

Max joseph space seen in …..

Degeneration seen in lichen planus (3)

A

Lichen planus

Basal layer degeneration
Hyaline degeneration
Liquefactive degeneration

64
Q

Pseudo-isomorphic phenomenon seen in ….(2)

A
  1. Warts
  2. Molluscum contagiosum
65
Q

Pityriasis rosea is caused by ….organisms

Nail involvement in psoriasis is due to involvement of which structure

A

HHV6 & HHV7

Proximal nail matrix

66
Q

Causative agent of scabies

Definitive diagnosis of sporotrichosis generally depends on …..labs

A

Sarcoptes scabeii

Culture and biopsy

67
Q

Commonest site of atopic dermatitis

A

Antecubital fossa

68
Q

Frie test is dx of ….

Most cutaneous eruption in SLE

A

LGV

Erythema of light exposed area

69
Q

Which substance causes allergic contact dermatitis ?

Shagreen patch is usually found in which region

A

Parthenium

Lumbosacral

70
Q

Melanocyte are present in which layer of skin

Dx of congenital syphilis is established by ….

A

Stratum basale

IgM FTA-ABS

71
Q

Vagabonds disease is also known as …..

PUVA therapy is done in ….(2)

A

Pediculosis corporis

Psoriasis
Vitiligo

72
Q

Painless ulcer with painless LAP suggests …..

Unnoticed painless papule with suppurative LAP s/o …..

A

Syphilis

LGV

73
Q

Condition in which there is deposition of IgA in dermo-epidermal junction

A

Dermatitis herpetiformis

74
Q

Use of thalidomide in leprosy

Oral drug (antibiotic) for management of acne

A

Type 2 lepra reaction

Doxycycline

75
Q

Important Histological feature of tuberculoid leprosy

Pautriers microabscess is associated with …..

A

Non caseating granuloma

Mycosis fungoides

76
Q

Otomycosis is caused by ..(2)

A
  1. Aspergillus fumigatus
  2. Candida
77
Q

DOC for non-gonococcal urethritis

Leprosy does not affect which organ of females

A

Azithromycin

Uterus

78
Q

Chronic familial benign pemphigus is also known as …..

A

Hailey hailey disease

79
Q

……naevus may lead to melanoma

Mc type of basal cell carcinoma

A

Junctional

Nodulo ulcerative

80
Q

Kerion in a …….infection

Layer of skin involved in acantholysis is ….

A

Fungal

Suprabasal/ intra-epidermal

81
Q

Tzank smear finding in pemphigus

BPAG1 & BPAG2 & deposition of C3 & IgG at basement membrane suggest ….

A

Acantholytic cells

Bullous pemphigoid

82
Q

Wavelength of carbon dioxide laser

Carpet tract sign is seen in ….

A

10600 nm

DLE

83
Q

Lines of Blaschoko is present in …..

Duration of Rx for acrodermatitis enteropathica

A

Lines of development

Lifelong

84
Q

Vitamin D is synthesized by which cells ….

Stain used to study fungal morphology in tissue sections

A

Keratinocytes

PAS

85
Q

Angioedema is ……

Wavelength of UV beta rays

A

Edema of sc tissue

280 nm

86
Q

Fordyce spots are ectopic ……

Flaky paint dermatosis is seen in …..

A

Sebacceous glands

Kwashiorkar

87
Q

Koenen’s tumor is seen in ….

Which species of trichophyton is zoophilic?

A

Tuberous sclerosis

Tinea mentagrophytes

88
Q

Id reaction is seen in …..

Molluscum sebaceum is another term for ….

A

Dermatophytes

Keratoacanthoma

89
Q

Dimple’s sign is seen in ……

Dermatophytic LAD is seen in ……

A

Dermatofibroma

Mycosis fungoides

90
Q

Felon is ….

A

Terminal pulp space infection

91
Q

Cicatrizing alopecia with perifollicular blue gray patches is most common associated with …..

A

Whitish lesion in buccal mucosa

92
Q

Earliest feature of tuberous sclerosis

Adenoma sebaceum in tuberous sclerosis is ……

A

Ash leaf spot

Angiofibroma

93
Q

Scarring alopecia is seen in …..

Flag sign is seen in …..

94
Q

Malignant pustule is …..

A

Rapidly spreading rodent ulcer

95
Q

Mc organism causing tinea capitis

Most important investigation in diagnosing leprosy

A

Trichophyton tonsurans

Slit skin smear for AFB

96
Q

A 7 year old child from Bihar is having hypopigmented anesthetic patch on his face. Most probable diagnosis

A

Intermediate leprosy

97
Q

Slit skin smear is negative for which type of leprosy

Primary bullous lesion is seen in which type of syphilis

A

Neuritic leprosy

Congenital

98
Q

Rx of choice in pustular psoriasis

Drug induced pemphigus is seen in ……drug (3)

A

Methotrexate

Penicillin
Captopril
Enalapril

99
Q

Mouth lesions are seen in ….

Fordyce spots are …..

A

Lichen planus

Ectopic sebaceous glands

100
Q

Acantholysis is seen in ……layer of skin

Discharging sinus is seen in …..

A

Epidermis

Actinomycosis

101
Q

Gonorrhoea resistant structure is ……

Underlying internal malignancy is not shown by ……

A

Testis

Granuloma annulare

102
Q

Skin disease not caused by staphylococcus

Skin biopsy in leprosy is characterized by ……

A

Erysipelas

Peri-appendigeal granulomatis

103
Q

Not a lesion of leprosy

A 25 year old has palatal ulcers and skin blisters. Most likely dx is ……

A

Vesicle

Pemphigus vulgaris

104
Q

Hydroquinone compounds cause depigmentation by their action on which enzyme

Circinate balanitis is seen in ….

A

Tyrosinase

Reiter’s syndrome

105
Q

Cytoid bodies are found in …..

Norwegian scabies is causing by ……organism

A

Lichen planus

Female acarus scabiei

106
Q

Vitamin D is synthesized by which cells of skin

Erythroderma is also known as ……

A

Prickle cells

Exfoliative dermatitis

107
Q

2 year old child with reddish color on wood’s lamp

A

Congenital erythropoeitic porphyria

108
Q

Thimble pitting of nails is seen in …..

Saw tooth rete ridges are seen in …..

A

Psoriasis

Lichen planus

Neet Pg (11 decks)

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