Physio Flashcards
GLUT RBC
GLUT 1 3
GLUT 2
1liver 2pancreas 3small intestine BasoLateral side 2 words
GLUT 4
1adipose 2SK ms
GLUT 5
small intestine L U M E N 5 letters
receptors SI lumen
SGLT1 and GLUT5
Osmolality formula
2Na PLUS Glucose div 18 PLUS urea div 2.8
Na K Atpase How many Na and K
toKen or twoKin Two K in
Location of NA K ATPase pump in most cells
basolateral except in choroid plexus
Give 2 brain tumors arising from dividing neurons of infants
1Neuroblastoma 2Retinoblastoma
Destruction of myelin sheath PNS
GBS schwann cell made
Destruction of myelin sheath CNS
MS oligodendrocyte made
Unmyelinated parts of axon
Nodes of Ranvier
Disaeses using retrograde axonal tansport dynein 2
1Tetanus 2Botulism
Term to describe collection of Neurons in PNS
ganglion
Term to describe collection of Neurons in CNS
Nucleus or Locus or Substantia
Axons connecting cerebrum and brainstem
Capsule
Collection of axons with common origin and destination
Tract
Bundle of axons in PNS
Nerve except optic nerve
Production of ACH
Nucleus Basalis of Meynert
3 substances made from Tryptophan
Niacin Melatonin Serotonin production requires B6
Parkinson drugs BALSA
Bromocriptine Amantadine Levi/carbidopa Selegilin Antimuscarinic bextropine
Converterd to Melatonin in PINEAL GLAND
Serotonin
Nitrous oxide vs Nitric oxide
N20 laughing gas while NO is vasodilatorand or inhibitor synthesized PRN
Precursor of NO
Arginine
Eponym of NO
endothelium derived relazing factor
Precursor of GABA
Derived from GLUTAMATE the excitatory NT
Enterochromaffin cell vs enterochromaffin like cells in stomach
Enterochromaffin cell SEROTONIN vs enterochromaffin like cells HISTAMINE
Histamine prodn in CNS
Tuberomamillary nucleus of hypothalamus
Purely excitatory NT
glutamate
Purely inhibitory NT 4
GABA Glycine Serotonin NO
excitatory of inihibitory NTs 4
aCh NorE Epi Dopamine
Char of action potential 3
1stereotypical size and shape 2propagating 3all or none
Na channel blocker of Neurona 2
1Tetrodotoxin from puffer fish AWAKE BUT PARALYZED 2Saxitoxin in Dinoflagellates eaten by tahong
K channel blocker of Neuron
Tetraehylammonium from puffer fish
Anterograde amnesia
hippocampus
Retrograde amnesia
thalamus
REM sleep what wave
Beta wave
EEG awake with eyes closed
A wave
EEG awake eyes open
Beta wave also REM sleep EEG
Brain disorder
Theta wave
Infant EEG
delta wave
EEG petit mal seizure
Spike and wave
DOC status epilepticus
pedia phenytoin
DOC status epilepticus
adult Frenzodiazepins
smallest drug
lithium
% BS to brain
14 percent of CO
BP when autoregulation happens
60 to 140 mmHg
Afferent and efferent of Baroreceptors
Afferent CN 9 10 Efferent CN 10
CSF formed per day
500 ml at 0.5 ml per minute
No BBB
1area postrema 2 areas of hypothalamus 3pineal gland
SNS vs PNS pupil
SNS L1 mydriasis or dilate via radial ms PNS miosis or constrict via ciliary ms
SNS vs PNS HR
SNS B1 tachy PNS brady
SNS vs PNS heart
contractility SNS B1 inc PNS dec
SNS vs PNS Skin and splanchnic
SNS L1 constrict PNS no effect
SNS vs PNS Sk muscle
SNS B2 dilate
SNS vs PNS Bronchi
SNS B2 dilation PNS constrictiom
SNS vs PNS GIT Bladder walls
SNS B2 relaxation PNS contraction
SNS vs PNS GIT Bladder sphincters
SNS L1 contraction PNS realxation
SNS vs PNS GIT secretion
SNS no effect PNS inc
SNS vs PNS Uterus
SNS contraction L1 relaxation B2
SNS vs PNS Sweat glands
SNS muscarinic inc
SNS vs PNS liver
SNS gluconeogenesis glycogenolysis L B2 PNS glycogenesis
SNS vs PNS Fat cells
SNS B1 lipolysis PNS no effect
Kidney SNS vs PNS
SNS B1 input to macula densa INC renin PNS no effect
Dorsal colum nuclei in thalamus
VPL likod
Trigeminal pathway
VPM mukha
Anterolateral pathway
VPI
Pain NT 2
Glutamate and Substance P
Fast pain fiber and NT
A delta Glutamate ventrobasal complex
Slow pain fiber and NT
Type C Substance P intralaminar nucleus of thalamus
Referred pain due to
sharing of 2nd order neurons in spinal cord of visceral and skin pain fibers
Flow of aqueous humor
Clilary body TO posterior chamber TO anterior chamber angle TO pupil TO anterior chamber TO trabecular meshwork TO canal of schlemm TO uveoscleral veins
most powerful structure of optical system
cornea
center of vision
fovea
enables lens to change shape
zonula
middle vascular layer
uvea
area without sensory cell
optic disc
first part of brain to receive visual input
optic chiasm
relay station of visual cortex
lateral geniculate body
keeps image focused on the retina
lens
BS to retina
choroid
where aqueous humor is produced
ciliary body
occupational exposure decibel
greater than 85dB for 8 hours a day 10 years
Ear pain and permanent damage
120 dB
Endolymph
scala MEDIA high K
Perilymph
scala VESTIBULI and TYMPANI high in Na
2 muscles of inner ear
Tensor tympany to malleus Stapedius to stapes
High frequency sound
hair cells at BASE of basilar membrane
Low frequency sound
hair cells at APEX of basilar membrane
Linear acceleration
Utricle and Saccule using MACULA as sensory organ
Angular acceleration
Semicircular canals Ant Post and Lat uses CRISTA AMPULARIS as sensor
Noxious stimuli path
unmyelinated C fibers CNV
Attachment of malleus and stapes
Malleus to tympanic membrane Stapes to oval window Incus attached to both
Most anterior part of retina where light passes first
ganglion layer
Sensory relay for axons of ganglion cells from eye
lateral geniculate body CNII
Sensory relay for auditory system
medial geniculate body
Concave lens DIVERGES or converges light
Concave diverge ConVEx conVErge
Hair cells inner before outer depolarization
K entry NOT Na entry like other cells
Photoreceptors when activated
HYPERpolarize rather than depolarize
Sensory relay for axons of ganglion cells from eye movement CN III IV VI
Medial longitudinal fasciculus
SV
EDV minus ESV or CO dvided by HR
Ejection fraction
SV divided by EDV N is 55 percent
Pulse pressure
Systole minus Diastole OR SV divided by complaince
CVP
MAP minus ICP
a wave
distal 1/3 of diastole . Time when atria contracts with slight inc in atrial pressure
c wave
isovolumetric contraction.Ventricles contracting with closed valves. High pressure in atria not yet overcome.
v wave
isovolumetric relaxation. Atrial filling.
PR interval
duration of AV node conduction N 0.20
QT interval
ventricular depolarization and repolarization
BP control excitatory
MedulLATEX lateral portion is excitatory
BP control inhibitory
Medulla medial portion is inhibitory
Membranous ossification
M for Mukha bones of face and calvarium. The rest is by endochondral ossification.
Several Parts Build a Diaphragm
1Septum transversum 2Pleuriperitoneal fold 3Body wall 4Dorsal mesentery of esophagus
CO formula
SVC x HR or MAP divided by TPR
Semilunar valves
Aortic and pulmonic valves
Anatomic location kidney
T12 to L3
Renal circulation
Renal artery to Segmental artery to Interlobar artery to Arcuate artery to Interlobular artery inlcuding cortical radial or radial artery to Afferent arteriole to Glomerular capillaries to Efferent arteriole to Peritubular capillaries or vasa recta to Interlobular vein to Arcuate vein to Interlobar vein to Segmental vein to Renal vein
EPO production
interstitial cells of the peritubilar capillaries
CO going into Kidney
22 percent
Normal GFR
125 ml per minute or 180 L per day but 20 percent lower in women
Dopamine effects
LOW inc renal blood flow without affecting gfr MED B1 effects High L1 effects
Elevated H levels effect on K and Ca
HYPERkalemia HYPERcalcemia
Thirst center
Anteroventral wall of the 3rd Ventricle AND Preoptic nuclei
Micturition center
Pons
pH compatible with life
6.8 to 8.0
Serum anion gap
2NA MINUS Cl plus HCO3 normal value 12 mas o menos 4
MUDPILES of high anion gap metabolic acidosis
Methanol Uremia DKA Paraldehyde Phenformin Iron tablets INH Lactic acidosis Ethylene glycol Salicylates or ASA
HARDUP of normal anion gap metabolic acidosis
Hyperalimentation Acetazolamide RTA Diarrhea Ureteroenteric fistula Pancreaticoduodenal fistula
Sites of production RBC fetal to adult 4 YOUNG LIVER SYNTHESIZES BLOOD
Yolk sac to Liver and Spleen to Bone marrow in sternum iliac ribs and vertebrae
RBC with nucleus
Orthochromatic erythroblast
Bleeding time
1 to 6 min
Clotting time
6 to 10 min
Prothrombi time tests
Extrinsic pathway N 12s
Lung volumes ITER
1Inspiratory reserve volume 2Tidal volume 3Expiratory reserve volume 4Residual volume
Lung capacities sum of 2 or more lung volumes
Inspiratory capacity Functional residual capacity vital capacity Total lung capacity
Minute respiratory volume
TV x RR
Alveolar ventilation per minute
RR x difference of Vt 500ml and physiologic dead space 150ml
Highest ventilation
Base
Highest perfusion
Base
Highest Ventilation Perfusion ratio
Apex
Carboxyhemoglobin
CO plus Hgb
Carbaminohemoglobin
CO2 plus Hgb
Haldane effeect
Inc O2 will cause CO2 to unload fr Hgb
Bohr effect
Inc Hydrogen ions will cause O2 to unload from Hgb
Center of respiration
Medulla DRG If exercising overdrive mechanism used VRG
Central chemoreceptors
Medulla
Modifies respiratory rhythm
Pons
Peripheral chemoreceptors of respiration
Carotid bodies CN IX Aortic bodies CN X activated P02 less than 70mmHg
Chief cells 2 kinds
1 PARATHYROID chief cells PTH 2 STOMACH chief cells Pepsinogen
Innervation of Parotid gland
CN 9
Innervation of Submandibular and Sublingual
CN 7
Bile pathway
Hepatocytes to Bile canaliculi to Interlobular septa to Terminal bile ducts to Hepatic duct to Common hepatic duct to Cystic duct to Gallbladder
Sperm formation
semineferous tubules
sperm motility
epididymis
sperm storage
vas deferens
secretion of fructose and prostaglandins
seminal vesicle
makes semen alkaline
prostate gland
Path of semen SEVEn UP
1 Seminiferous tubules 2 epididymis 3 vas deferens 4 ejaculatory ducts 5 Urethra 6 Penis
Where did the acrosome come from
Golgi body
where is the mitochondria of the sperm
in the body of TAIL
Activation of sperm happens when
it gets in contact with Female genital tract
Released in duodenum and jejunum by I cells
Cholecystokinin
Inc secretion of pancreatic enzymes and bicarbonate
Inhibit gastric emptying
Produced by S cells in duodenum. What is its function.
Secretin
Increase HCO3 secretion of pancrease and gallbladder
Decrease gastric secretion
Calcium absorption sites in kidney 3
1 proximal tubule - co transport with Na reabsorption
2 distal tubule - reabsorption controlled by parathyroid hormone
3 thick ascending loop of henle - Na/K/2Cl creates gradient for calcium reabsorption. Normally follows reabsorption of Na, K and Cl.
Action of prostaglandin on kidneys
Prostaglandin DILATE the afferent arteriole therefore
Increase RPF and Increse GFR
Note: NSAIDs inhibit prostaglandin so decrease renal perfusion and GFR
Action of Angiotensin II on kidney
Constrics afferent < efferent arteriole with overall effect of DECrease RPF and INCrease GFR
What would increase renal blood flow
Stimulation of renal DOPAMINE and bradykinin receptors.
Both are vasodilators of the arterioles
Released in duodenum and jejunum by I cells
Cholecystokinin
Inc secretion of pancreatic enzymes and bicarbonate
Inhibit gastric emptying
Produced by S cells in duodenum. What is its function.
Secretin
Increase HCO3 secretion of pancrease and gallbladder
Decrease gastric secretion
Calcium absorption sites in kidney 3
1 proximal tubule - co transport with Na reabsorption
2 distal tubule - reabsorption controlled by parathyroid hormone
3 thick ascending loop of henle - Na/K/2Cl creates gradient for calcium reabsorption. Normally follows reabsorption of Na, K and Cl.
Action of prostaglandin on kidneys
Prostaglandin DILATE the afferent arteriole therefore
Increase RPF and Increse GFR
Note: NSAIDs inhibit prostaglandin so decrease renal perfusion and GFR
Action of Angiotensin II on kidney
Constrics afferent < efferent arteriole with overall effect of DECrease RPF and INCrease GFR
What would increase renal blood flow
Stimulation of renal DOPAMINE and bradykinin receptors.
Both are vasodilators of the arterioles