PHRM 825: Obesity

Question 1

Obesity definition

Answer 1

Increased storage of energy from an imbalance between energy in and energy out over time, leading to an accumulation of body fat to the point that health is compromised

Question 2

How is obesity measured?

Answer 2

BMI

Question 3

What does BMI directly correlate with?

Answer 3

Morbidity and mortality

Question 4

What populations is BMI limited in?

Answer 4

• High muscle mass
• Edema
• Pregnancy
• Height <5 feet
• Elderly

Question 5

What are the different BMI classifications?

Answer 5

Underweight: 18.5 or less
Normal weight: 18.6-24.9
Overweight: 25-29.9
Obese: 30 or greater

Question 6

Which type of factors typically affect weight the most?

Answer 6

Environmental factors (not so much genetics)

Question 7

What 4 medical conditions can lead to obesity?

Answer 7

• Depression
• Growth hormone deficiency
• Cushing syndrome
• Polycystic ovary syndrome

Question 8

What 5 drug classes can lead to obesity?

Answer 8

• Anticonvulsants
• Antidepressants
• Atypical antipsychotics
• Conventional antipsychotics
• Hormones

Question 9

What 4 psychosocial factors are associated with obesity?

Answer 9

• Eating disorders
• Low self-esteem
• Depression
• Social stigmatization

Question 10

What waist circumference indicates a patient that would benefit from weight loss therapy?

Answer 10

Females: >88cm (35in)
Males: >102cm (40in)

Question 11

What are the goals of weight loss therapy?

Answer 11

• Reduction in body weight (5-10% over 6 months)
• Maintain body weight
• Prevent weight gain
• Improve obesity related conditions

Question 12

What are appropriate daily caloric intakes for patients who want to lose weight?

Answer 12

• 1200-1500 for females
• 1500-1800 for males
• Or reduce pts total intake by 500-750 calories

Question 13

What are the criteria for bariatric surgery?

Answer 13

BMI 40 or more or BMI 35 or more with coexisting conditions AND motivated to lose weight AND have not responded to behavioral treatment with or without phamacotherapy

Question 14

What is the average weight loss with bariatric surgery?

Answer 14

50% body weight

Question 15

What are 6 classes of prescription drug therapy options for weight loss?

Answer 15

• CNS stimulants
• Lipase inhibitor
• Serotonin 5-HT2C receptor agonist
• Sypathomimetic and anticonvulsant
• Opioid antagonists and dopamine/norepinephrine reuptake inhibitor
• GLP-1 agonist

Question 16

When is prescription drug therapy indicated for obesity?

Answer 16

• BMI 30 or more (27 or more with other risk factors)

- May be initiated in combination with dietary therapy, physical activity, and behavioral therapy

Question 17

5 medications indicated for chronic management of obesity

Answer 17

• Orlistat
• Lorcaserin
• Phentermine and topiramate
• Naltrexone and bupropion extended release
• Liraglutide